AutismKB 2.0

Annotation Detail for CD74


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Basic Information Top
Gene Symbol:CD74 ( DHLAG,HLADG,II,Ia-GAMMA )
Gene Full Name: CD74 molecule, major histocompatibility complex, class II invariant chain
Band: 5q33.1
Quick LinksEntrez ID:972; OMIM: 142790; Uniprot ID:HG2A_HUMAN; ENSEMBL ID: ENSG00000019582; HGNC ID: 1697
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus56 / 56401299
neonate28 / 31097900
infant0 / 236200 
juvenile56 / 555561007
adult1091 / 1939121562
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor12 / 12794937
bladder carcinoma6 / 17475343
breast (mammary gland) tumor10 / 94178106
cervical tumor21 / 34366611
chondrosarcoma17 / 82823205
colorectal tumor37 / 114246323
esophageal tumor8 / 17290462
gastrointestinal tumor46 / 119369385
germ cell tumor28 / 263845106
glioma44 / 106883411
head and neck tumor18 / 136302132
kidney tumor18 / 68959261
leukemia39 / 95842406
liver tumor47 / 96359487
lung tumor100 / 103127969
lymphoma504 / 717557023
non-neoplasia188 / 972501933
normal3602 / 33603071071
ovarian tumor125 / 766821630
pancreatic tumor84 / 104616802
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer12 / 102680116
retinoblastoma0 / 463560 
skin tumor15 / 124949120
soft tissue/muscle tissue tumor43 / 125191343
uterine tumor85 / 90257941
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue58 / 131064425
adrenal gland37 / 331971114
ascites7 / 40015174
bladder18 / 29757604
blood99 / 123478801
bone49 / 71655683
bone marrow10 / 48801204
brain877 / 1100989796
cervix23 / 48171477
connective tissue201 / 1492551346
ear1 / 1621261
embryonic tissue5 / 21572223
esophagus12 / 20209593
eye81 / 211054383
heart128 / 896261428
intestine487 / 2344722077
kidney29 / 211777136
larynx0 / 241450 
liver95 / 207743457
lung282 / 336974836
lymph424 / 442709577
lymph node210 / 916102292
mammary gland58 / 153271378
mouth6 / 6705289
muscle48 / 107715445
nerve7 / 15768443
ovary140 / 1020511371
pancreas134 / 214812623
parathyroid6 / 20539292
pharynx14 / 41328338
pituitary gland9 / 16585542
placenta98 / 280825348
prostate36 / 189345190
salivary gland13 / 20155645
skin17 / 21057480
spleen575 / 5395210657
stomach126 / 966191304
testis14 / 33044242
thymus208 / 811312563
thyroid35 / 47473737
tonsil800 / 1699947061
trachea10 / 52413190
umbilical cord6 / 13680438
uterus122 / 232878523
vascular17 / 51780328
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209619_at
Cell line Expression level Expression bar
721_B_lymphoblasts10299.25
Adipocyte11.8
AdrenalCortex581.3
Adrenalgland1849.3
Amygdala574.9
Appendix346.85
AtrioventricularNode202.25
BDCA4+_DentriticCells8240.85
Bonemarrow1196.25
BronchialEpithelialCells12.05
CD105+_Endothelial775.75
CD14+_Monocytes8259.8
CD19+_BCells(neg._sel.)10015.7
CD33+_Myeloid5150.8
CD34+2381.4
CD4+_Tcells708.25
CD56+_NKCells1993
CD71+_EarlyErythroid111.3
CD8+_Tcells548.5
CardiacMyocytes13.4
Caudatenucleus576.2
Cerebellum153.5
CerebellumPeduncles236.9
CiliaryGanglion585
CingulateCortex81.25
Colorectaladenocarcinoma72.3
DorsalRootGanglion1101.6
FetalThyroid276.3
Fetalbrain21.6
Fetalliver204.35
Fetallung779.85
GlobusPallidus123.9
Heart3130.35
Hypothalamus761.55
Kidney1320.35
Leukemia_chronicMyelogenousK-56211.65
Leukemia_promyelocytic-HL-605201
Leukemialymphoblastic(MOLT-4)14
Liver1178.3
Lung8790.1
Lymphnode4500.3
Lymphoma_burkitts(Daudi)6050.1
Lymphoma_burkitts(Raji)16134.6
MedullaOblongata157.45
OccipitalLobe330.15
OlfactoryBulb1832.5
Ovary433.85
Pancreas155.75
PancreaticIslet698.8
ParietalLobe152.1
Pituitary974.7
Placenta806.3
Pons245.2
PrefrontalCortex474.55
Prostate914.75
Salivarygland1967.6
SkeletalMuscle122.65
Skin462
SmoothMuscle10.15
Spinalcord2798.45
SubthalamicNucleus159.8
SuperiorCervicalGanglion161.75
TemporalLobe148.85
Testis172.75
TestisGermCell221.5
TestisIntersitial122.9
TestisLeydigCell153.15
TestisSeminiferousTubule108.5
Thalamus710.8
Thymus3302.05
Thyroid1984.15
Tongue443.6
Tonsil5548.15
Trachea2419.7
TrigeminalGanglion406.3
Uterus699.1
UterusCorpus297.3
WholeBlood4718.65
Wholebrain138.25
colon1122.75
pineal_day589.42
pineal_night642.46
retina3010.85
small_intestine2893.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14061_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.41 ± 0.57
Basal Forebrain10.45 ± 0.65
Basal Part of Pons11.26 ± 0.41
Cerebellar Cortex9.91 ± 0.35
Cerebellar Nuclei12.3 ± 0.46
Claustrum10.23 ± 0.43
Epithalamus12.04 ± 0.71
Frontal Lobe10.15 ± 0.8
Globus Pallidus12.72 ± 0.54
Hypothalamus10.75 ± 1.47
Insula10.53 ± 0.67
Limbic Lobe9.93 ± 0.83
Mesencephalon10.53 ± 0.88
Myelencephalon10.49 ± 0.82
Occipital Lobe10.34 ± 1.09
Parietal Lobe10.24 ± 0.71
Pontine Tegmentum10.25 ± 0.64
Striatum11.28 ± 0.65
Subthalamus11.29 ± 0.21
Temporal Lobe10.41 ± 0.73
Thalamus10.5 ± 0.54
White Matter12.56 ± 0.65
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HG2A_HUMAN_0 0 0 0 DLISNNEQLPMLGR PRIDE
HG2A_HUMAN_0 0 0 0 HSLEQKPTDAPPK PRIDE
HG2A_HUMAN_0 0 0 0 LTVTSQNLQLENLR PRIDE
HG2A_HUMAN_21 14 21 34 DLISNNEQLPMLGR PRIDE
HG2A_HUMAN_77 17 77 93 LDKLTVTSQNLQLENLR PRIDE
HG2A_HUMAN_80 14 80 93 LTVTSQNLQLENLR PRIDE
PAp00001706 14 22 35 DLISNNEQLPMLGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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