AutismKB 2.0

Annotation Detail for ZNF646


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Basic Information Top
Gene Symbol:ZNF646 ( KIAA0296 )
Gene Full Name: zinc finger protein 646
Band: 16p11.2
Quick LinksEntrez ID:9726; OMIM: NA; Uniprot ID:ZN646_HUMAN; ENSEMBL ID: ENSG00000167395; HGNC ID: 29004
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult30 / 193912115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor1 / 2638453
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma4 / 7175555
non-neoplasia0 / 972500 
normal29 / 33603078
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer4 / 10268038
retinoblastoma3 / 4635664
skin tumor2 / 12494916
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow1 / 4880120
brain8 / 11009897
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye6 / 21105428
heart1 / 8962611
intestine9 / 23447238
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph4 / 4427090
lymph node1 / 9161010
mammary gland5 / 15327132
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate5 / 18934526
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204876_at
Cell line Expression level Expression bar
721_B_lymphoblasts31.75
Adipocyte23.2
AdrenalCortex28.15
Adrenalgland20.95
Amygdala6.05
Appendix25.1
AtrioventricularNode30.7
BDCA4+_DentriticCells25.2
Bonemarrow24.95
BronchialEpithelialCells21.45
CD105+_Endothelial23.85
CD14+_Monocytes25.05
CD19+_BCells(neg._sel.)24.55
CD33+_Myeloid28.95
CD34+27.8
CD4+_Tcells25.5
CD56+_NKCells24.7
CD71+_EarlyErythroid23.7
CD8+_Tcells21.45
CardiacMyocytes30.35
Caudatenucleus38.6
Cerebellum19.45
CerebellumPeduncles43.85
CiliaryGanglion19.25
CingulateCortex36.15
Colorectaladenocarcinoma19
DorsalRootGanglion20.15
FetalThyroid23.25
Fetalbrain22.65
Fetalliver20.45
Fetallung16.1
GlobusPallidus18.35
Heart29.3
Hypothalamus25.1
Kidney25.95
Leukemia_chronicMyelogenousK-56227.5
Leukemia_promyelocytic-HL-6021.05
Leukemialymphoblastic(MOLT-4)19.45
Liver30.85
Lung25.5
Lymphnode20
Lymphoma_burkitts(Daudi)51.3
Lymphoma_burkitts(Raji)32.35
MedullaOblongata25
OccipitalLobe26.85
OlfactoryBulb18.75
Ovary16.65
Pancreas18.8
PancreaticIslet20.85
ParietalLobe26.1
Pituitary27.55
Placenta23.8
Pons33.1
PrefrontalCortex21.95
Prostate23.95
Salivarygland19.25
SkeletalMuscle29.4
Skin20.1
SmoothMuscle26.35
Spinalcord25.35
SubthalamicNucleus30.65
SuperiorCervicalGanglion32.3
TemporalLobe21.6
Testis32.4
TestisGermCell25.3
TestisIntersitial21.1
TestisLeydigCell26.6
TestisSeminiferousTubule37.6
Thalamus24.6
Thymus17.8
Thyroid12.95
Tongue25.15
Tonsil24.5
Trachea19.65
TrigeminalGanglion24.55
Uterus16.8
UterusCorpus24.6
WholeBlood25.5
Wholebrain17.05
colon12.2
pineal_day29.12
pineal_night28.36
retina26.65
small_intestine8.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P181510
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.4 ± 0.66
Basal Forebrain8.13 ± 0.4
Basal Part of Pons7.65 ± 0.25
Cerebellar Cortex7.42 ± 0.31
Cerebellar Nuclei8.21 ± 1.02
Claustrum7.75 ± 0.58
Epithalamus9.31 ± 0.51
Frontal Lobe7.78 ± 0.69
Globus Pallidus10.17 ± 0.72
Hypothalamus8.43 ± 1.1
Insula7.58 ± 0.73
Limbic Lobe7.64 ± 0.83
Mesencephalon8.1 ± 0.76
Myelencephalon8.09 ± 0.63
Occipital Lobe7.7 ± 0.62
Parietal Lobe7.61 ± 0.73
Pontine Tegmentum7.6 ± 0.68
Striatum7.81 ± 0.85
Subthalamus7.85 ± 0.51
Temporal Lobe7.51 ± 0.66
Thalamus7.96 ± 0.47
White Matter9.08 ± 0.83
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
6820429M01CBCerebellum27.13
32.94
6820429M01CTXCerebral cortex35.96
23.44
6820429M01HIPHippocampal region32.46
39.83
6820429M01HPFHippocampal formation32.23
32.52
6820429M01HYHypothalamus6.91
5
6820429M01LSXLateral septal complex4.5
2.67
6820429M01MBMidbrain14.55
12.15
6820429M01MYMedulla17.47
15.11
6820429M01OLFOlfactory bulb36.44
24.45
6820429M01PPons12.02
10.21
6820429M01PALPallidum13.95
11.02
6820429M01RHPRetrohippocampal region31.18
22.53
6820429M01sAMYStriatum-like amygdalar nuclei16.1
9.77
6820429M01STRStriatum23.62
15.64
6820429M01STRdStriatum dorsal region25.17
17
6820429M01STRvStriatum ventral region28.09
17.63
6820429M01THThalamus22.74
18.18
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ZN646_HUMAN_513 7 513 519 VHCKAAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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