AutismKB 2.0

Annotation Detail for SLK


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Basic Information Top
Gene Symbol:SLK ( KIAA0204,LOSK,MGC133067,STK2,bA16H23.1,se20-9 )
Gene Full Name: STE20-like kinase
Band: 10q24.33-q25.1
Quick LinksEntrez ID:9748; OMIM: NA; Uniprot ID:SLK_HUMAN; ENSEMBL ID: ENSG00000065613; HGNC ID: 11088
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus30 / 56401253
neonate2 / 3109764
infant0 / 236200 
juvenile3 / 5555653
adult102 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor4 / 34366116
chondrosarcoma4 / 8282348
colorectal tumor11 / 11424696
esophageal tumor2 / 17290115
gastrointestinal tumor7 / 11936958
germ cell tumor5 / 26384518
glioma1 / 1068839
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia3 / 9584231
liver tumor3 / 9635931
lung tumor4 / 10312738
lymphoma1 / 7175513
non-neoplasia3 / 9725030
normal143 / 336030742
ovarian tumor4 / 7668252
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor4 / 12494932
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites2 / 4001549
bladder3 / 29757100
blood5 / 12347840
bone3 / 7165541
bone marrow1 / 4880120
brain16 / 110098914
cervix4 / 4817183
connective tissue3 / 14925520
ear1 / 1621261
embryonic tissue8 / 21572237
esophagus2 / 2020998
eye7 / 21105433
heart5 / 8962655
intestine15 / 23447263
kidney9 / 21177742
larynx2 / 2414582
liver7 / 20774333
lung24 / 33697471
lymph1 / 4427022
lymph node4 / 9161043
mammary gland10 / 15327165
mouth0 / 670520 
muscle8 / 10771574
nerve1 / 1576863
ovary2 / 10205119
pancreas13 / 21481260
parathyroid5 / 20539243
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta14 / 28082549
prostate2 / 18934510
salivary gland0 / 201550 
skin9 / 21057442
spleen0 / 539520 
stomach4 / 9661941
testis6 / 33044218
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord1 / 1368073
uterus23 / 23287898
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206874_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts25.8
Adipocyte5.5
AdrenalCortex7.7
Adrenalgland7.15
Amygdala57.75
Appendix9.35
AtrioventricularNode6.8
BDCA4+_DentriticCells17.1
Bonemarrow5.7
BronchialEpithelialCells12.55
CD105+_Endothelial20.25
CD14+_Monocytes15.65
CD19+_BCells(neg._sel.)8.85
CD33+_Myeloid22.7
CD34+66.6
CD4+_Tcells23.6
CD56+_NKCells37.9
CD71+_EarlyErythroid9.45
CD8+_Tcells34.05
CardiacMyocytes10.05
Caudatenucleus123.3
Cerebellum6.9
CerebellumPeduncles10.05
CiliaryGanglion5.25
CingulateCortex20.1
Colorectaladenocarcinoma8.05
DorsalRootGanglion5.75
FetalThyroid22.65
Fetalbrain56.75
Fetalliver7.1
Fetallung58.3
GlobusPallidus10.05
Heart7.65
Hypothalamus25.1
Kidney5.25
Leukemia_chronicMyelogenousK-56219.35
Leukemia_promyelocytic-HL-609.45
Leukemialymphoblastic(MOLT-4)6.1
Liver7.75
Lung9.4
Lymphnode9.95
Lymphoma_burkitts(Daudi)9.15
Lymphoma_burkitts(Raji)12.75
MedullaOblongata45.55
OccipitalLobe38.25
OlfactoryBulb10.9
Ovary5.25
Pancreas10.05
PancreaticIslet20.4
ParietalLobe15.5
Pituitary12.75
Placenta8.55
Pons14.45
PrefrontalCortex159
Prostate26.95
Salivarygland7.55
SkeletalMuscle9.5
Skin6.85
SmoothMuscle7.05
Spinalcord12.85
SubthalamicNucleus12.15
SuperiorCervicalGanglion11.05
TemporalLobe11.95
Testis6.55
TestisGermCell15.35
TestisIntersitial6.45
TestisLeydigCell7.05
TestisSeminiferousTubule7.5
Thalamus13.6
Thymus6.6
Thyroid72.8
Tongue11.5
Tonsil7.7
Trachea7.6
TrigeminalGanglion8.1
Uterus102.05
UterusCorpus12.35
WholeBlood20.05
Wholebrain17.5
colon11.65
pineal_day48.62
pineal_night39.56
retina14.525
small_intestine13.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P202199
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.84 ± 0.27
Basal Forebrain8.33 ± 0.23
Basal Part of Pons7.66 ± 0.28
Cerebellar Cortex7.69 ± 0.13
Cerebellar Nuclei7.74 ± 0.2
Claustrum7.83 ± 0.25
Epithalamus8.09 ± 0.2
Frontal Lobe7.79 ± 0.27
Globus Pallidus7.98 ± 0.15
Hypothalamus7.7 ± 0.2
Insula7.83 ± 0.23
Limbic Lobe7.92 ± 0.24
Mesencephalon7.96 ± 0.32
Myelencephalon7.9 ± 0.33
Occipital Lobe8.21 ± 0.31
Parietal Lobe7.93 ± 0.25
Pontine Tegmentum8 ± 0.32
Striatum8.76 ± 0.38
Subthalamus7.95 ± 0.1
Temporal Lobe7.84 ± 0.19
Thalamus7.94 ± 0.24
White Matter8.2 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SlkCBCerebellum28.56
37.86
SlkCTXCerebral cortex100
89.2
SlkHIPHippocampal region82.58
100
SlkHPFHippocampal formation91.65
100
SlkHYHypothalamus29.08
24.85
SlkLSXLateral septal complex63.86
64.9
SlkMBMidbrain34.08
33.49
SlkMYMedulla43.06
54.26
SlkOLFOlfactory bulb81.56
81.59
SlkPPons37.62
45.34
SlkPALPallidum49.8
50.12
SlkRHPRetrohippocampal region100
100
SlksAMYStriatum-like amygdalar nuclei78.18
67.9
SlkSTRStriatum100
98.89
SlkSTRdStriatum dorsal region100
100
SlkSTRvStriatum ventral region100
85.21
SlkTHThalamus47.99
48.07
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001057 11 1153 1163 CHLLVEHETQK Peptide Atlas
SLK_HUMAN_1132 11 1132 1142 DLQLQCEANVR PRIDE
SLK_HUMAN_157 13 157 169 AGNILFTLDGDIK PRIDE
SLK_HUMAN_280 21 280 300 WTTSQLLQHPFVTVDSNKPIR PRIDE
SLK_HUMAN_872 11 872 882 QYDQEIENLEK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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