Annotation Detail for TOX
Basic Information Top
| Gene Symbol: | TOX ( KIAA0808,TOX1 ) |
|---|---|
| Gene Full Name: | thymocyte selection-associated high mobility group box |
| Band: | 8q12.1 |
| Quick Links | Entrez ID:9760; OMIM: 606863; Uniprot ID:TOX_HUMAN; ENSEMBL ID: ENSG00000198846; HGNC ID: 18988 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.491805
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 2 / 70761 | 28 |  |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 8 / 564012 | 14 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 16 / 1939121 | 8 |  |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 2 / 82823 | 24 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 1 / 263845 | 3 | |
| glioma | 1 / 106883 | 9 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 2 / 95842 | 20 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 1 / 103127 | 9 | |
| lymphoma | 4 / 71755 | 55 |  |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 55 / 3360307 | 16 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 1 / 104616 | 9 | |
| primitive neuroectodermal tumor of the CNS | 2 / 125680 | 15 | |
| prostate cancer | 2 / 102680 | 19 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 2 / 123478 | 16 | |
| bone | 2 / 71655 | 27 | |
| bone marrow | 1 / 48801 | 20 | |
| brain | 6 / 1100989 | 5 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 1 / 16212 | 61 | |
| embryonic tissue | 5 / 215722 | 23 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 5 / 211054 | 23 | |
| heart | 0 / 89626 | 0 | |
| intestine | 2 / 234472 | 8 | |
| kidney | 3 / 211777 | 14 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 11 / 336974 | 32 | |
| lymph | 1 / 44270 | 22 | |
| lymph node | 10 / 91610 | 109 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 3 / 214812 | 13 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 1 / 280825 | 3 | |
| prostate | 2 / 189345 | 10 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 3 / 330442 | 9 | |
| thymus | 8 / 81131 | 98 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 1 / 232878 | 4 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 204529_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 8.5 | |
| Adipocyte | 8.1 | |
| AdrenalCortex | 10.45 | |
| Adrenalgland | 7.55 | |
| Amygdala | 10.85 | |
| Appendix | 11 | |
| AtrioventricularNode | 10.2 | |
| BDCA4+_DentriticCells | 8.55 | |
| Bonemarrow | 9.3 | |
| BronchialEpithelialCells | 7.9 | |
| CD105+_Endothelial | 8.4 | |
| CD14+_Monocytes | 9.15 | |
| CD19+_BCells(neg._sel.) | 10.1 | |
| CD33+_Myeloid | 11.1 | |
| CD34+ | 17.9 | |
| CD4+_Tcells | 9.35 | |
| CD56+_NKCells | 326.75 |  |
| CD71+_EarlyErythroid | 8.3 | |
| CD8+_Tcells | 22.75 | |
| CardiacMyocytes | 15.9 | |
| Caudatenucleus | 7.6 | |
| Cerebellum | 7 | |
| CerebellumPeduncles | 10.15 | |
| CiliaryGanglion | 7.7 | |
| CingulateCortex | 10 | |
| Colorectaladenocarcinoma | 8.45 | |
| DorsalRootGanglion | 8 | |
| FetalThyroid | 8.65 | |
| Fetalbrain | 10.6 | |
| Fetalliver | 7.75 | |
| Fetallung | 7.1 | |
| GlobusPallidus | 7.05 | |
| Heart | 14.85 | |
| Hypothalamus | 9.85 | |
| Kidney | 7.9 | |
| Leukemia_chronicMyelogenousK-562 | 7.5 | |
| Leukemia_promyelocytic-HL-60 | 12.75 | |
| Leukemialymphoblastic(MOLT-4) | 351.9 | |
| Liver | 12.65 | |
| Lung | 9.65 | |
| Lymphnode | 7.65 | |
| Lymphoma_burkitts(Daudi) | 11.4 | |
| Lymphoma_burkitts(Raji) | 53.1 | |
| MedullaOblongata | 10 | |
| OccipitalLobe | 10 | |
| OlfactoryBulb | 7 | |
| Ovary | 6.2 | |
| Pancreas | 7.1 | |
| PancreaticIslet | 22.35 | |
| ParietalLobe | 9.75 | |
| Pituitary | 9.95 | |
| Placenta | 8.1 | |
| Pons | 8.6 | |
| PrefrontalCortex | 60.35 | |
| Prostate | 10.3 | |
| Salivarygland | 7.35 | |
| SkeletalMuscle | 13.3 | |
| Skin | 7.65 | |
| SmoothMuscle | 9.75 | |
| Spinalcord | 9.45 | |
| SubthalamicNucleus | 8.25 | |
| SuperiorCervicalGanglion | 12.65 | |
| TemporalLobe | 8.2 | |
| Testis | 7.75 | |
| TestisGermCell | 17.4 | |
| TestisIntersitial | 7.25 | |
| TestisLeydigCell | 9.1 | |
| TestisSeminiferousTubule | 7.25 | |
| Thalamus | 9.15 | |
| Thymus | 314.65 | |
| Thyroid | 10.1 | |
| Tongue | 9.7 | |
| Tonsil | 12.15 | |
| Trachea | 7.15 | |
| TrigeminalGanglion | 10.8 | |
| Uterus | 6.75 | |
| UterusCorpus | 9 | |
| WholeBlood | 9.85 | |
| Wholebrain | 17.4 | |
| colon | 37.35 | |
| pineal_day | 10.32 | |
| pineal_night | 9.9 | |
| retina | 10.4 | |
| small_intestine | 55.45 | |
- Probe name: CUST_656_PI416408490
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 5.99 ± 0.72 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.5 ± 0.36 | |
| Basal Part of Pons | 4.68 ± 0.65 | |
| Cerebellar Cortex | 4.78 ± 0.57 | |
| Cerebellar Nuclei | 5.07 ± 0.76 | |
| Claustrum | 5.96 ± 0.52 | |
| Epithalamus | 5.08 ± 0.92 | |
| Frontal Lobe | 5.43 ± 0.65 | |
| Globus Pallidus | 5.57 ± 0.74 | |
| Hypothalamus | 5.76 ± 0.32 | |
| Insula | 5.47 ± 0.59 | |
| Limbic Lobe | 5.31 ± 0.85 | |
| Mesencephalon | 5.69 ± 0.77 | |
| Myelencephalon | 5.59 ± 0.79 | |
| Occipital Lobe | 6.17 ± 0.7 | |
| Parietal Lobe | 5.92 ± 0.69 | |
| Pontine Tegmentum | 5.78 ± 0.48 | |
| Striatum | 4.99 ± 1 | |
| Subthalamus | 4.32 ± 0.13 | |
| Temporal Lobe | 5.67 ± 0.67 | |
| Thalamus | 6.23 ± 0.51 | |
| White Matter | 5.07 ± 0.48 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Tox | CB | Cerebellum | 3.93 | |
| 4.47 | | |||
| Tox | CTX | Cerebral cortex | 25.72 | |
| 23 | | |||
| Tox | HIP | Hippocampal region | 4.98 | |
| 4.99 | | |||
| Tox | HPF | Hippocampal formation | 12.99 | |
| 12.32 | | |||
| Tox | HY | Hypothalamus | 5.08 | |
| 4.08 | | |||
| Tox | LSX | Lateral septal complex | 3.45 | |
| 2.4 | | |||
| Tox | MB | Midbrain | 3.91 | |
| 3.77 | | |||
| Tox | MY | Medulla | 6.6 | |
| 8.23 | | |||
| Tox | OLF | Olfactory bulb | 6.79 | |
| 5.26 | | |||
| Tox | P | Pons | 3.58 | |
| 3.43 | | |||
| Tox | PAL | Pallidum | 3.26 | |
| 3.49 | | |||
| Tox | RHP | Retrohippocampal region | 27.9 | |
| 23.8 | | |||
| Tox | sAMY | Striatum-like amygdalar nuclei | 5.02 | |
| 3.62 | | |||
| Tox | STR | Striatum | 2.84 | |
| 2.34 | | |||
| Tox | STRd | Striatum dorsal region | 2.75 | |
| 2.45 | | |||
| Tox | STRv | Striatum ventral region | 1.76 | |
| 1.13 | | |||
| Tox | TH | Thalamus | 19.56 | |
| 17.79 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00424471 | 13 | 281 | 293 | GQNPNATFGEVSK | Peptide Atlas |
| TOX_HUMAN_0 | 0 | 0 | 0 | DTQAAIKGQNPNATFGEVSK | PRIDE |