AutismKB 2.0

Annotation Detail for KIAA0586


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Basic Information Top
Gene Symbol:KIAA0586 ( Talpid3 )
Gene Full Name: KIAA0586
Band: 14q23.1
Quick LinksEntrez ID:9786; OMIM: 610178; Uniprot ID:Q6UV20_HUMAN; ENSEMBL ID: ENSG00000100578; HGNC ID: 19960
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult35 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor2 / 17290115
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal64 / 336030719
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain11 / 11009899
cervix1 / 4817120
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus2 / 2020998
eye4 / 21105418
heart1 / 8962611
intestine2 / 2344728
kidney0 / 2117770 
larynx0 / 241450 
liver3 / 20774314
lung4 / 33697411
lymph1 / 4427022
lymph node4 / 9161043
mammary gland1 / 1532716
mouth2 / 6705229
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta3 / 28082510
prostate2 / 18934510
salivary gland0 / 201550 
skin6 / 21057428
spleen0 / 539520 
stomach0 / 966190 
testis27 / 33044281
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205631_at
Cell line Expression level Expression bar
721_B_lymphoblasts20.9
Adipocyte12.65
AdrenalCortex13.7
Adrenalgland10.7
Amygdala11.8
Appendix18.25
AtrioventricularNode9.75
BDCA4+_DentriticCells12.3
Bonemarrow14.65
BronchialEpithelialCells11.8
CD105+_Endothelial14.95
CD14+_Monocytes12.15
CD19+_BCells(neg._sel.)16.95
CD33+_Myeloid15.05
CD34+16.3
CD4+_Tcells14.4
CD56+_NKCells15.3
CD71+_EarlyErythroid25.9
CD8+_Tcells13
CardiacMyocytes16.8
Caudatenucleus11.4
Cerebellum10.3
CerebellumPeduncles16.8
CiliaryGanglion8.7
CingulateCortex12.85
Colorectaladenocarcinoma12.55
DorsalRootGanglion9.95
FetalThyroid12.2
Fetalbrain12.85
Fetalliver12.1
Fetallung9.3
GlobusPallidus9.1
Heart15.65
Hypothalamus13.7
Kidney10.45
Leukemia_chronicMyelogenousK-56211.55
Leukemia_promyelocytic-HL-6012.05
Leukemialymphoblastic(MOLT-4)11.15
Liver16.4
Lung13.35
Lymphnode11
Lymphoma_burkitts(Daudi)21.9
Lymphoma_burkitts(Raji)17.35
MedullaOblongata11.45
OccipitalLobe11.35
OlfactoryBulb9.85
Ovary8.6
Pancreas9.9
PancreaticIslet13.5
ParietalLobe13.35
Pituitary14.95
Placenta12.65
Pons12
PrefrontalCortex14.75
Prostate15.05
Salivarygland10.25
SkeletalMuscle14.85
Skin9.5
SmoothMuscle14.95
Spinalcord13.6
SubthalamicNucleus11.3
SuperiorCervicalGanglion17.45
TemporalLobe11.45
Testis10.8
TestisGermCell26.5
TestisIntersitial36.9
TestisLeydigCell18.55
TestisSeminiferousTubule20.05
Thalamus12.8
Thymus11.5
Thyroid14.7
Tongue12.75
Tonsil14.75
Trachea10.65
TrigeminalGanglion12.35
Uterus10.2
UterusCorpus11.2
WholeBlood13.2
Wholebrain9.45
colon12.65
pineal_day16.9
pineal_night17.08
retina15.05
small_intestine12.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P106127
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.84 ± 0.22
Basal Forebrain8.85 ± 0.2
Basal Part of Pons8.69 ± 0.18
Cerebellar Cortex8.87 ± 0.18
Cerebellar Nuclei8.77 ± 0.18
Claustrum8.8 ± 0.23
Epithalamus8.91 ± 0.31
Frontal Lobe8.75 ± 0.22
Globus Pallidus8.92 ± 0.25
Hypothalamus8.96 ± 0.26
Insula8.79 ± 0.17
Limbic Lobe8.82 ± 0.32
Mesencephalon9.06 ± 0.3
Myelencephalon8.86 ± 0.27
Occipital Lobe9.19 ± 0.34
Parietal Lobe8.83 ± 0.23
Pontine Tegmentum8.87 ± 0.21
Striatum9.25 ± 0.25
Subthalamus8.95 ± 0.16
Temporal Lobe8.76 ± 0.21
Thalamus8.84 ± 0.24
White Matter9.78 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
2700049A03RikCBCerebellum28.27
34.74
2700049A03RikCTXCerebral cortex34.14
24.33
2700049A03RikHIPHippocampal region40.07
56.1
2700049A03RikHPFHippocampal formation37.35
41.89
2700049A03RikHYHypothalamus12.91
9.35
2700049A03RikLSXLateral septal complex5.19
3.58
2700049A03RikMBMidbrain19.13
15.77
2700049A03RikMYMedulla30.09
28.24
2700049A03RikOLFOlfactory bulb30.15
23.51
2700049A03RikPPons21.52
20.22
2700049A03RikPALPallidum11.37
9.54
2700049A03RikRHPRetrohippocampal region32.56
24.19
2700049A03RiksAMYStriatum-like amygdalar nuclei15.54
10.8
2700049A03RikSTRStriatum16.18
11.37
2700049A03RikSTRdStriatum dorsal region14.79
10.76
2700049A03RikSTRvStriatum ventral region26.6
16.89
2700049A03RikTHThalamus22.51
18.4
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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