AutismKB 2.0

Annotation Detail for SPCS2


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Basic Information Top
Gene Symbol:SPCS2 ( KIAA0102,MGC117366 )
Gene Full Name: signal peptidase complex subunit 2 homolog (S. cerevisiae)
Band: 11q13.4
Quick LinksEntrez ID:9789; OMIM: NA; Uniprot ID:SPCS2_HUMAN; ENSEMBL ID: ENSG00000118363; HGNC ID: 28962
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus33 / 56401258
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult109 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma5 / 17475286
breast (mammary gland) tumor8 / 9417884
cervical tumor0 / 343660 
chondrosarcoma8 / 8282396
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor8 / 26384530
glioma2 / 10688318
head and neck tumor14 / 136302102
kidney tumor4 / 6895958
leukemia7 / 9584273
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal162 / 336030748
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer4 / 10268038
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor13 / 90257144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder6 / 29757201
blood3 / 12347824
bone5 / 7165569
bone marrow7 / 48801143
brain29 / 110098926
cervix1 / 4817120
connective tissue8 / 14925553
ear6 / 16212370
embryonic tissue11 / 21572250
esophagus0 / 202090 
eye5 / 21105423
heart1 / 8962611
intestine16 / 23447268
kidney8 / 21177737
larynx0 / 241450 
liver11 / 20774352
lung20 / 33697459
lymph0 / 442700 
lymph node3 / 9161032
mammary gland13 / 15327184
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas18 / 21481283
parathyroid9 / 20539438
pharynx6 / 41328145
pituitary gland0 / 165850 
placenta17 / 28082560
prostate12 / 18934563
salivary gland4 / 20155198
skin9 / 21057442
spleen1 / 5395218
stomach7 / 9661972
testis12 / 33044236
thymus5 / 8113161
thyroid13 / 47473273
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord1 / 1368073
uterus21 / 23287890
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201239_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts452.25
Adipocyte111.05
AdrenalCortex48
Adrenalgland135.8
Amygdala56.55
Appendix16.55
AtrioventricularNode33.55
BDCA4+_DentriticCells748.15
Bonemarrow148.25
BronchialEpithelialCells162.2
CD105+_Endothelial195.1
CD14+_Monocytes267.95
CD19+_BCells(neg._sel.)441.6
CD33+_Myeloid292
CD34+395.4
CD4+_Tcells171.15
CD56+_NKCells507.7
CD71+_EarlyErythroid264.4
CD8+_Tcells166.4
CardiacMyocytes119.7
Caudatenucleus77.05
Cerebellum65.9
CerebellumPeduncles44.2
CiliaryGanglion27.95
CingulateCortex62
Colorectaladenocarcinoma70.3
DorsalRootGanglion36.6
FetalThyroid58.05
Fetalbrain65.6
Fetalliver166.6
Fetallung118.45
GlobusPallidus56.45
Heart38.25
Hypothalamus134.95
Kidney70.25
Leukemia_chronicMyelogenousK-562126.3
Leukemia_promyelocytic-HL-60131.4
Leukemialymphoblastic(MOLT-4)114.5
Liver39
Lung122.35
Lymphnode137.1
Lymphoma_burkitts(Daudi)256.3
Lymphoma_burkitts(Raji)36
MedullaOblongata66
OccipitalLobe113.3
OlfactoryBulb107.85
Ovary86.5
Pancreas75.75
PancreaticIslet175.45
ParietalLobe75.55
Pituitary228.65
Placenta259.6
Pons42.3
PrefrontalCortex88.55
Prostate142.65
Salivarygland157.9
SkeletalMuscle8.35
Skin15.1
SmoothMuscle192.6
Spinalcord123.3
SubthalamicNucleus57.75
SuperiorCervicalGanglion10.7
TemporalLobe46.75
Testis107.65
TestisGermCell60
TestisIntersitial58.55
TestisLeydigCell56.25
TestisSeminiferousTubule31.3
Thalamus103.45
Thymus182.8
Thyroid154.4
Tongue12
Tonsil128.55
Trachea245
TrigeminalGanglion9.25
Uterus48.4
UterusCorpus95.45
WholeBlood127.7
Wholebrain123.95
colon161.65
pineal_day208.22
pineal_night230.84
retina158.8
small_intestine210.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P104861
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.57 ± 0.92
Basal Forebrain2.5 ± 0.87
Basal Part of Pons1.97 ± 0.54
Cerebellar Cortex2.05 ± 0.62
Cerebellar Nuclei2.42 ± 0.63
Claustrum2.88 ± 0.63
Epithalamus2.22 ± 0.61
Frontal Lobe2.19 ± 0.73
Globus Pallidus2.9 ± 0.6
Hypothalamus2.06 ± 0.7
Insula2.01 ± 0.93
Limbic Lobe2.03 ± 0.65
Mesencephalon2.37 ± 0.75
Myelencephalon2.18 ± 0.59
Occipital Lobe2.08 ± 0.65
Parietal Lobe2.27 ± 0.68
Pontine Tegmentum2.31 ± 0.77
Striatum2.19 ± 0.8
Subthalamus2.43 ± 0.59
Temporal Lobe2.03 ± 0.71
Thalamus2.15 ± 0.56
White Matter2.53 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Spcs2CBCerebellum22.24
27.83
Spcs2CTXCerebral cortex58.9
46.86
Spcs2HIPHippocampal region45.73
50.26
Spcs2HPFHippocampal formation46.73
45.7
Spcs2HYHypothalamus59.73
58.64
Spcs2LSXLateral septal complex42.06
35.07
Spcs2MBMidbrain38.48
38.7
Spcs2MYMedulla38.16
47.27
Spcs2OLFOlfactory bulb68.36
57.02
Spcs2PPons36.4
44.46
Spcs2PALPallidum50.52
52.51
Spcs2RHPRetrohippocampal region49.97
39.05
Spcs2sAMYStriatum-like amygdalar nuclei77.97
64.72
Spcs2STRStriatum40.59
31.63
Spcs2STRdStriatum dorsal region34.22
26.32
Spcs2STRvStriatum ventral region40.39
29.38
Spcs2THThalamus37.05
32.69
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002386 19 196 214 FFDHSGTLVMDAYEPEISR Peptide Atlas
SPCS2_HUMAN_138 8 138 145 SIFLVAHR PRIDE
SPCS2_HUMAN_196 19 196 214 FFDHSGTLVMDAYEPEISR PRIDE
SPCS2_HUMAN_2 9 2 10 AAAAVQGGR PRIDE
SPCS2_HUMAN_215 9 215 223 LHDSLAIER PRIDE
SPCS2_HUMAN_74 11 74 84 YVENFGLIDGR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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