AutismKB 2.0

Annotation Detail for ARHGEF11


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ARHGEF11 ( DKFZp667F1223,GTRAP48,KIAA0380,PDZ-RHOGEF )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 11
Band: 1q23.1
Quick LinksEntrez ID:9826; OMIM: 605708; Uniprot ID:ARHGB_HUMAN; ENSEMBL ID: ENSG00000132694; HGNC ID: 14580
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst6 / 6231996
fetus31 / 56401254
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult108 / 193912155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma3 / 8282336
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor4 / 26384515
glioma2 / 10688318
head and neck tumor14 / 136302102
kidney tumor3 / 6895943
leukemia7 / 9584273
liver tumor1 / 9635910
lung tumor7 / 10312767
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal128 / 336030738
ovarian tumor8 / 76682104
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone2 / 7165527
bone marrow0 / 488010 
brain21 / 110098919
cervix3 / 4817162
connective tissue3 / 14925520
ear1 / 1621261
embryonic tissue16 / 21572274
esophagus0 / 202090 
eye11 / 21105452
heart0 / 896260 
intestine14 / 23447259
kidney5 / 21177723
larynx3 / 24145124
liver3 / 20774314
lung22 / 33697465
lymph0 / 442700 
lymph node2 / 9161021
mammary gland4 / 15327126
mouth3 / 6705244
muscle0 / 1077150 
nerve2 / 15768126
ovary8 / 10205178
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx9 / 41328217
pituitary gland0 / 165850 
placenta8 / 28082528
prostate8 / 18934542
salivary gland0 / 201550 
skin12 / 21057456
spleen0 / 539520 
stomach10 / 96619103
testis9 / 33044227
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus11 / 23287847
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202913_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.5
Adipocyte8.75
AdrenalCortex10.9
Adrenalgland8.05
Amygdala10.55
Appendix9.95
AtrioventricularNode7.7
BDCA4+_DentriticCells8.25
Bonemarrow9.3
BronchialEpithelialCells7
CD105+_Endothelial8.2
CD14+_Monocytes11.1
CD19+_BCells(neg._sel.)7.8
CD33+_Myeloid11.6
CD34+9.75
CD4+_Tcells8.85
CD56+_NKCells7.95
CD71+_EarlyErythroid7.9
CD8+_Tcells7.1
CardiacMyocytes10.25
Caudatenucleus9.5
Cerebellum15.5
CerebellumPeduncles13.3
CiliaryGanglion7.9
CingulateCortex11.4
Colorectaladenocarcinoma10.2
DorsalRootGanglion8.25
FetalThyroid9.3
Fetalbrain12.1
Fetalliver7.9
Fetallung6.85
GlobusPallidus7.95
Heart11.2
Hypothalamus11.1
Kidney8.15
Leukemia_chronicMyelogenousK-5628.15
Leukemia_promyelocytic-HL-608
Leukemialymphoblastic(MOLT-4)7.25
Liver11.7
Lung9.3
Lymphnode7.55
Lymphoma_burkitts(Daudi)11.15
Lymphoma_burkitts(Raji)11.75
MedullaOblongata12.65
OccipitalLobe10.95
OlfactoryBulb8.15
Ovary8.15
Pancreas7.1
PancreaticIslet10.2
ParietalLobe13.75
Pituitary12.4
Placenta9.9
Pons10.6
PrefrontalCortex12.7
Prostate10.15
Salivarygland7.5
SkeletalMuscle12.4
Skin6.95
SmoothMuscle9.65
Spinalcord11.6
SubthalamicNucleus11.35
SuperiorCervicalGanglion11.95
TemporalLobe11.8
Testis12
TestisGermCell11.4
TestisIntersitial11.3
TestisLeydigCell13.25
TestisSeminiferousTubule17.6
Thalamus21.3
Thymus6.55
Thyroid10.45
Tongue8.8
Tonsil9.15
Trachea7.35
TrigeminalGanglion12.15
Uterus6.9
UterusCorpus8.1
WholeBlood10.15
Wholebrain9.95
colon8.85
pineal_day43.34
pineal_night26.52
retina11.45
small_intestine8.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P23421
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.54 ± 0.64
Basal Forebrain5.29 ± 0.25
Basal Part of Pons5.43 ± 0.59
Cerebellar Cortex5.44 ± 0.44
Cerebellar Nuclei5.44 ± 0.46
Claustrum6.03 ± 0.77
Epithalamus4.51 ± 0.25
Frontal Lobe5.31 ± 0.52
Globus Pallidus5.45 ± 0.56
Hypothalamus4.78 ± 0.66
Insula5.23 ± 0.55
Limbic Lobe5.64 ± 0.59
Mesencephalon5.4 ± 0.55
Myelencephalon5.48 ± 0.54
Occipital Lobe6.01 ± 0.5
Parietal Lobe5.66 ± 0.45
Pontine Tegmentum5.41 ± 0.58
Striatum5.2 ± 0.63
Subthalamus4.94 ± 0.48
Temporal Lobe5.4 ± 0.58
Thalamus5.65 ± 0.58
White Matter4.33 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Arhgef11CBCerebellum25.09
27.92
Arhgef11CTXCerebral cortex51.59
43.61
Arhgef11HIPHippocampal region28.64
39.53
Arhgef11HPFHippocampal formation31.01
35.62
Arhgef11HYHypothalamus11.24
9.44
Arhgef11LSXLateral septal complex17.75
13.47
Arhgef11MBMidbrain24.65
25.59
Arhgef11MYMedulla29.6
36.27
Arhgef11OLFOlfactory bulb49.2
46.7
Arhgef11PPons26.45
32.29
Arhgef11PALPallidum22.84
23.95
Arhgef11RHPRetrohippocampal region36.21
31.44
Arhgef11sAMYStriatum-like amygdalar nuclei21.85
16.93
Arhgef11STRStriatum12.21
10.3
Arhgef11STRdStriatum dorsal region9.38
8.45
Arhgef11STRvStriatum ventral region14.82
11.24
Arhgef11THThalamus23.15
21.83
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00496828 27 1112 1138 VELDDSDVFHGEPEPEELPGGTGSQQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved