AutismKB 2.0

Annotation Detail for MELK


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Basic Information Top
Gene Symbol:MELK ( HPK38,KIAA0175 )
Gene Full Name: maternal embryonic leucine zipper kinase
Band: 9p13.2
Quick LinksEntrez ID:9833; OMIM: 607025; Uniprot ID:MELK_HUMAN; ENSEMBL ID: ENSG00000165304; HGNC ID: 16870
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst6 / 6231996
fetus9 / 56401215
neonate2 / 3109764
infant1 / 2362042
juvenile7 / 55556125
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma4 / 8282348
colorectal tumor4 / 11424635
esophageal tumor3 / 17290173
gastrointestinal tumor7 / 11936958
germ cell tumor22 / 26384583
glioma4 / 10688337
head and neck tumor6 / 13630244
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor8 / 9635983
lung tumor3 / 10312729
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal75 / 336030722
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites5 / 40015124
bladder2 / 2975767
blood2 / 12347816
bone4 / 7165555
bone marrow2 / 4880140
brain21 / 110098919
cervix2 / 4817141
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue16 / 21572274
esophagus3 / 20209148
eye4 / 21105418
heart3 / 8962633
intestine6 / 23447225
kidney4 / 21177718
larynx0 / 241450 
liver8 / 20774338
lung6 / 33697417
lymph2 / 4427045
lymph node5 / 9161054
mammary gland2 / 15327113
mouth7 / 67052104
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta7 / 28082524
prostate2 / 18934510
salivary gland0 / 201550 
skin7 / 21057433
spleen1 / 5395218
stomach2 / 9661920
testis18 / 33044254
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus6 / 23287825
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204825_at
Cell line Expression level Expression bar
721_B_lymphoblasts358.5
Adipocyte10.55
AdrenalCortex9.35
Adrenalgland7.35
Amygdala8
Appendix9.75
AtrioventricularNode7.25
BDCA4+_DentriticCells10.75
Bonemarrow25.2
BronchialEpithelialCells79.7
CD105+_Endothelial148.35
CD14+_Monocytes8.15
CD19+_BCells(neg._sel.)8.4
CD33+_Myeloid20.55
CD34+100.75
CD4+_Tcells8.25
CD56+_NKCells10.15
CD71+_EarlyErythroid139.35
CD8+_Tcells7.25
CardiacMyocytes141.3
Caudatenucleus7.15
Cerebellum6.85
CerebellumPeduncles9.6
CiliaryGanglion6.6
CingulateCortex8.35
Colorectaladenocarcinoma191.85
DorsalRootGanglion6.85
FetalThyroid7.6
Fetalbrain7.55
Fetalliver57
Fetallung15.85
GlobusPallidus6.15
Heart14.35
Hypothalamus7.95
Kidney7.1
Leukemia_chronicMyelogenousK-56271.5
Leukemia_promyelocytic-HL-60114
Leukemialymphoblastic(MOLT-4)213.35
Liver12.4
Lung8.3
Lymphnode6.95
Lymphoma_burkitts(Daudi)134.5
Lymphoma_burkitts(Raji)73.3
MedullaOblongata7.35
OccipitalLobe7.4
OlfactoryBulb6.2
Ovary6
Pancreas27.4
PancreaticIslet9.15
ParietalLobe8.95
Pituitary9.3
Placenta8.25
Pons8.85
PrefrontalCortex9.1
Prostate8.65
Salivarygland7.15
SkeletalMuscle10.25
Skin6.85
SmoothMuscle13.4
Spinalcord9.4
SubthalamicNucleus7.5
SuperiorCervicalGanglion13.45
TemporalLobe7.8
Testis7.4
TestisGermCell35.65
TestisIntersitial12.6
TestisLeydigCell12.6
TestisSeminiferousTubule15.8
Thalamus8.65
Thymus46.7
Thyroid8.85
Tongue21.9
Tonsil38
Trachea6.95
TrigeminalGanglion11.15
Uterus6.3
UterusCorpus8.4
WholeBlood8
Wholebrain5.95
colon70.65
pineal_day9.64
pineal_night9
retina9.9
small_intestine95.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8026_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.96 ± 0.97
Basal Forebrain1.55 ± 0.19
Basal Part of Pons1.34 ± 0.58
Cerebellar Cortex1.36 ± 0.68
Cerebellar Nuclei1.78 ± 0.72
Claustrum2.38 ± 0.84
Epithalamus1.26 ± 0.7
Frontal Lobe1.39 ± 0.61
Globus Pallidus2.15 ± 0.34
Hypothalamus1.66 ± 0.69
Insula1.46 ± 0.55
Limbic Lobe1.53 ± 0.58
Mesencephalon1.67 ± 0.66
Myelencephalon1.56 ± 0.63
Occipital Lobe1.54 ± 0.56
Parietal Lobe1.53 ± 0.64
Pontine Tegmentum1.55 ± 0.63
Striatum1.72 ± 0.5
Subthalamus1.64 ± 0.59
Temporal Lobe1.43 ± 0.59
Thalamus1.5 ± 0.55
White Matter2.05 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
MelkCBCerebellum4.85
4.22
MelkCTXCerebral cortex25.26
17.17
MelkHIPHippocampal region11.74
10.39
MelkHPFHippocampal formation10.39
8.27
MelkHYHypothalamus1.98
1.33
MelkLSXLateral septal complex0.57
0.38
MelkMBMidbrain2.9
2.35
MelkMYMedulla6.25
5.63
MelkOLFOlfactory bulb22.97
15.51
MelkPPons4.45
4.03
MelkPALPallidum4.24
3.08
MelkRHPRetrohippocampal region8.24
5.37
MelksAMYStriatum-like amygdalar nuclei2.92
1.9
MelkSTRStriatum9.49
6.34
MelkSTRdStriatum dorsal region9.86
6.42
MelkSTRvStriatum ventral region18.05
12.02
MelkTHThalamus1.44
1.11
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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