AutismKB 2.0

Annotation Detail for ZEB2


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Basic Information Top
Gene Symbol:ZEB2 ( FLJ42816,KIAA0569,SIP-1,SIP1,SMADIP1,ZFHX1B )
Gene Full Name: zinc finger E-box binding homeobox 2
Band: 2q22.3
Quick LinksEntrez ID:9839; OMIM: 605802; Uniprot ID:ZEB2_HUMAN; ENSEMBL ID: ENSG00000169554; HGNC ID: 14881
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus120 / 564012212
neonate4 / 31097128
infant0 / 236200 
juvenile3 / 5555653
adult93 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor13 / 26384549
glioma8 / 10688374
head and neck tumor1 / 1363027
kidney tumor4 / 6895958
leukemia16 / 95842166
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia7 / 9725071
normal312 / 336030792
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland4 / 33197120
ascites0 / 400150 
bladder0 / 297570 
blood18 / 123478145
bone4 / 7165555
bone marrow7 / 48801143
brain223 / 1100989202
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye7 / 21105433
heart4 / 8962644
intestine10 / 23447242
kidney8 / 21177737
larynx0 / 241450 
liver4 / 20774319
lung19 / 33697456
lymph0 / 442700 
lymph node12 / 91610130
mammary gland1 / 1532716
mouth0 / 670520 
muscle6 / 10771555
nerve2 / 15768126
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta15 / 28082553
prostate4 / 18934521
salivary gland1 / 2015549
skin10 / 21057447
spleen3 / 5395255
stomach3 / 9661931
testis10 / 33044230
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord0 / 136800 
uterus12 / 23287851
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203603_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.8
Adipocyte13.6
AdrenalCortex17.3
Adrenalgland10.1
Amygdala217.4
Appendix18.9
AtrioventricularNode13.3
BDCA4+_DentriticCells29.8
Bonemarrow12.2
BronchialEpithelialCells9
CD105+_Endothelial10.9
CD14+_Monocytes43.7
CD19+_BCells(neg._sel.)10.35
CD33+_Myeloid97.7
CD34+15.7
CD4+_Tcells8.7
CD56+_NKCells76.55
CD71+_EarlyErythroid10.45
CD8+_Tcells9.2
CardiacMyocytes24.15
Caudatenucleus27
Cerebellum9
CerebellumPeduncles14.2
CiliaryGanglion14.2
CingulateCortex48.2
Colorectaladenocarcinoma9.7
DorsalRootGanglion14.35
FetalThyroid11.5
Fetalbrain352.5
Fetalliver9.75
Fetallung9.1
GlobusPallidus10.85
Heart20.5
Hypothalamus32.55
Kidney9.95
Leukemia_chronicMyelogenousK-5628.7
Leukemia_promyelocytic-HL-608.6
Leukemialymphoblastic(MOLT-4)7.2
Liver17.1
Lung10.7
Lymphnode14.7
Lymphoma_burkitts(Daudi)13.65
Lymphoma_burkitts(Raji)17.8
MedullaOblongata28.7
OccipitalLobe17.55
OlfactoryBulb30.3
Ovary9.35
Pancreas9.4
PancreaticIslet11.6
ParietalLobe13.4
Pituitary11.75
Placenta9.95
Pons12.2
PrefrontalCortex187
Prostate11.3
Salivarygland9.45
SkeletalMuscle19.2
Skin11.95
SmoothMuscle11.9
Spinalcord121.25
SubthalamicNucleus11.55
SuperiorCervicalGanglion20.15
TemporalLobe11.9
Testis8.45
TestisGermCell8
TestisIntersitial9.5
TestisLeydigCell11.35
TestisSeminiferousTubule8.55
Thalamus14.8
Thymus7.25
Thyroid11.85
Tongue13.55
Tonsil10.8
Trachea8.05
TrigeminalGanglion17.45
Uterus51.6
UterusCorpus13.45
WholeBlood116.2
Wholebrain28.05
colon22.5
pineal_day15.64
pineal_night31.1
retina37.675
small_intestine26.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_675_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.04 ± 0.33
Basal Forebrain9.41 ± 0.54
Basal Part of Pons8.99 ± 0.56
Cerebellar Cortex8.58 ± 0.24
Cerebellar Nuclei9.41 ± 0.52
Claustrum9.56 ± 0.35
Epithalamus8.54 ± 0.49
Frontal Lobe9.01 ± 0.56
Globus Pallidus10.52 ± 0.28
Hypothalamus8.02 ± 0.73
Insula8.83 ± 0.4
Limbic Lobe9.21 ± 0.4
Mesencephalon9.21 ± 0.59
Myelencephalon9.12 ± 0.6
Occipital Lobe9.13 ± 0.43
Parietal Lobe9.18 ± 0.51
Pontine Tegmentum9.17 ± 0.53
Striatum9.32 ± 0.62
Subthalamus9.16 ± 0.24
Temporal Lobe9.05 ± 0.44
Thalamus9.12 ± 0.51
White Matter11.09 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zfhx1bCBCerebellum48.04
68.17
Zfhx1bCTXCerebral cortex100
100
Zfhx1bHIPHippocampal region100
100
Zfhx1bHPFHippocampal formation100
100
Zfhx1bHYHypothalamus52.75
39.51
Zfhx1bLSXLateral septal complex100
100
Zfhx1bMBMidbrain58.93
48.87
Zfhx1bMYMedulla87.51
79.82
Zfhx1bOLFOlfactory bulb100
100
Zfhx1bPPons57.56
48.67
Zfhx1bPALPallidum64.39
53.3
Zfhx1bRHPRetrohippocampal region100
100
Zfhx1bsAMYStriatum-like amygdalar nuclei51.03
43.67
Zfhx1bSTRStriatum56.44
50.31
Zfhx1bSTRdStriatum dorsal region56.65
49.45
Zfhx1bSTRvStriatum ventral region41.46
31.48
Zfhx1bTHThalamus56.14
43.61
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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