AutismKB 2.0

Annotation Detail for MED24


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Basic Information Top
Gene Symbol:MED24 ( ARC100,CRSP100,CRSP4,DRIP100,KIAA0130,MGC8748,THRAP4,TRAP100,hTRAP100 )
Gene Full Name: mediator complex subunit 24
Band: 17q21.1
Quick LinksEntrez ID:9862; OMIM: 607000; Uniprot ID:MED24_HUMAN; ENSEMBL ID: ENSG00000008838; HGNC ID: 22963
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body16 / 70761226
blastocyst11 / 62319176
fetus153 / 564012271
neonate5 / 31097160
infant2 / 2362084
juvenile5 / 5555689
adult306 / 1939121157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor29 / 94178307
cervical tumor1 / 3436629
chondrosarcoma7 / 8282384
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor15 / 119369125
germ cell tumor134 / 263845507
glioma20 / 106883187
head and neck tumor82 / 136302601
kidney tumor6 / 6895987
leukemia6 / 9584262
liver tumor17 / 96359176
lung tumor7 / 10312767
lymphoma1 / 7175513
non-neoplasia11 / 97250113
normal829 / 3360307246
ovarian tumor1 / 7668213
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer8 / 10268077
retinoblastoma4 / 4635686
skin tumor32 / 124949256
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland5 / 33197150
ascites3 / 4001574
bladder3 / 29757100
blood8 / 12347864
bone4 / 7165555
bone marrow4 / 4880181
brain594 / 1100989539
cervix1 / 4817120
connective tissue18 / 149255120
ear0 / 162120 
embryonic tissue35 / 215722162
esophagus0 / 202090 
eye19 / 21105490
heart3 / 8962633
intestine24 / 234472102
kidney20 / 21177794
larynx4 / 24145165
liver22 / 207743105
lung45 / 336974133
lymph1 / 4427022
lymph node13 / 91610141
mammary gland38 / 153271247
mouth74 / 670521103
muscle7 / 10771564
nerve1 / 1576863
ovary4 / 10205139
pancreas13 / 21481260
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta55 / 280825195
prostate13 / 18934568
salivary gland2 / 2015599
skin36 / 210574170
spleen10 / 53952185
stomach9 / 9661993
testis308 / 330442932
thymus68 / 81131838
thyroid5 / 47473105
tonsil3 / 16999176
trachea57 / 524131087
umbilical cord4 / 13680292
uterus39 / 232878167
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213043_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts44.2
Adipocyte5.8
AdrenalCortex5.2
Adrenalgland6.5
Amygdala10.55
Appendix5.25
AtrioventricularNode4.35
BDCA4+_DentriticCells25.45
Bonemarrow7
BronchialEpithelialCells77.4
CD105+_Endothelial66.85
CD14+_Monocytes9.35
CD19+_BCells(neg._sel.)10.25
CD33+_Myeloid16.5
CD34+66.95
CD4+_Tcells16.05
CD56+_NKCells44.8
CD71+_EarlyErythroid43.8
CD8+_Tcells22.9
CardiacMyocytes7.35
Caudatenucleus6
Cerebellum5.85
CerebellumPeduncles8.85
CiliaryGanglion4.75
CingulateCortex9.55
Colorectaladenocarcinoma31.8
DorsalRootGanglion4
FetalThyroid6.7
Fetalbrain15.45
Fetalliver5.65
Fetallung43.55
GlobusPallidus4.7
Heart18.5
Hypothalamus12.95
Kidney5.25
Leukemia_chronicMyelogenousK-56213.5
Leukemia_promyelocytic-HL-609
Leukemialymphoblastic(MOLT-4)40.85
Liver9.7
Lung33.5
Lymphnode6.65
Lymphoma_burkitts(Daudi)16.25
Lymphoma_burkitts(Raji)50.1
MedullaOblongata6.5
OccipitalLobe7
OlfactoryBulb6.05
Ovary3.9
Pancreas7.15
PancreaticIslet7.4
ParietalLobe7.55
Pituitary7.25
Placenta10.45
Pons5.6
PrefrontalCortex16.3
Prostate13.85
Salivarygland4.85
SkeletalMuscle7.75
Skin4.4
SmoothMuscle6.7
Spinalcord7.35
SubthalamicNucleus5.95
SuperiorCervicalGanglion5.6
TemporalLobe5.25
Testis12.45
TestisGermCell18
TestisIntersitial6.95
TestisLeydigCell7
TestisSeminiferousTubule8.7
Thalamus7.45
Thymus21.3
Thyroid15.45
Tongue6.3
Tonsil6.5
Trachea7.95
TrigeminalGanglion4.5
Uterus10.7
UterusCorpus5.95
WholeBlood6.7
Wholebrain14.75
colon7.45
pineal_day34.3
pineal_night27.24
retina13.975
small_intestine9.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P124760
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.77 ± 0.39
Basal Forebrain5.59 ± 0.33
Basal Part of Pons5.89 ± 0.38
Cerebellar Cortex5.84 ± 0.4
Cerebellar Nuclei5.97 ± 0.41
Claustrum5.81 ± 0.45
Epithalamus5.35 ± 0.25
Frontal Lobe5.84 ± 0.41
Globus Pallidus5.38 ± 0.33
Hypothalamus5.45 ± 0.51
Insula5.91 ± 0.32
Limbic Lobe5.74 ± 0.35
Mesencephalon5.66 ± 0.41
Myelencephalon5.76 ± 0.41
Occipital Lobe5.4 ± 0.32
Parietal Lobe5.64 ± 0.3
Pontine Tegmentum5.61 ± 0.41
Striatum5.42 ± 0.35
Subthalamus5.87 ± 0.29
Temporal Lobe5.9 ± 0.38
Thalamus5.82 ± 0.46
White Matter5.38 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Thrap4CBCerebellum16.95
13.46
Thrap4CTXCerebral cortex48.12
33.69
Thrap4HIPHippocampal region55.75
50.09
Thrap4HPFHippocampal formation55.49
45.61
Thrap4HYHypothalamus5.39
3.18
Thrap4LSXLateral septal complex6.42
3.56
Thrap4MBMidbrain7.67
4.92
Thrap4MYMedulla18.92
13.86
Thrap4OLFOlfactory bulb62.42
43.7
Thrap4PPons11.69
8.29
Thrap4PALPallidum6.84
4.58
Thrap4RHPRetrohippocampal region55.26
39.86
Thrap4sAMYStriatum-like amygdalar nuclei10.58
6.35
Thrap4STRStriatum11.29
6.52
Thrap4STRdStriatum dorsal region9.56
5.69
Thrap4STRvStriatum ventral region18.78
9.55
Thrap4THThalamus10.93
6.68
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00025965 30 539 568 ILNPDHPCFRPDSTKVESLVALLNNSSEMK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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