AutismKB 2.0

Annotation Detail for TLK1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TLK1 ( KIAA0137,PKU-beta )
Gene Full Name: tousled-like kinase 1
Band: 2q31.1
Quick LinksEntrez ID:9874; OMIM: 608438; Uniprot ID:TLK1_HUMAN; ENSEMBL ID: ENSG00000198586; HGNC ID: 11841
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus25 / 56401244
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult92 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor3 / 17290173
gastrointestinal tumor7 / 11936958
germ cell tumor14 / 26384553
glioma7 / 10688365
head and neck tumor11 / 13630280
kidney tumor1 / 6895914
leukemia3 / 9584231
liver tumor5 / 9635951
lung tumor3 / 10312729
lymphoma3 / 7175541
non-neoplasia3 / 9725030
normal125 / 336030737
ovarian tumor3 / 7668239
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer11 / 102680107
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder1 / 2975733
blood4 / 12347832
bone2 / 7165527
bone marrow4 / 4880181
brain29 / 110098926
cervix1 / 4817120
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus3 / 20209148
eye6 / 21105428
heart1 / 8962611
intestine7 / 23447229
kidney14 / 21177766
larynx0 / 241450 
liver8 / 20774338
lung17 / 33697450
lymph1 / 4427022
lymph node11 / 91610120
mammary gland6 / 15327139
mouth2 / 6705229
muscle5 / 10771546
nerve3 / 15768190
ovary2 / 10205119
pancreas5 / 21481223
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta14 / 28082549
prostate15 / 18934579
salivary gland2 / 2015599
skin2 / 2105749
spleen3 / 5395255
stomach4 / 9661941
testis14 / 33044242
thymus1 / 8113112
thyroid9 / 47473189
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210379_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts23.5
Adipocyte5.25
AdrenalCortex6.4
Adrenalgland4.8
Amygdala5.45
Appendix6.4
AtrioventricularNode4.85
BDCA4+_DentriticCells6.7
Bonemarrow5.7
BronchialEpithelialCells5.1
CD105+_Endothelial5.35
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)20.25
CD33+_Myeloid6.8
CD34+6.45
CD4+_Tcells6.2
CD56+_NKCells6.8
CD71+_EarlyErythroid5.15
CD8+_Tcells5.45
CardiacMyocytes8.8
Caudatenucleus4.85
Cerebellum4.4
CerebellumPeduncles6.35
CiliaryGanglion4.55
CingulateCortex5.6
Colorectaladenocarcinoma5.45
DorsalRootGanglion4.6
FetalThyroid5.3
Fetalbrain5.25
Fetalliver4.85
Fetallung4.2
GlobusPallidus4.2
Heart7.6
Hypothalamus5.55
Kidney4.65
Leukemia_chronicMyelogenousK-5624.85
Leukemia_promyelocytic-HL-604.8
Leukemialymphoblastic(MOLT-4)4.25
Liver7.9
Lung5.8
Lymphnode4.55
Lymphoma_burkitts(Daudi)7.1
Lymphoma_burkitts(Raji)8.15
MedullaOblongata4.85
OccipitalLobe4.8
OlfactoryBulb4.25
Ovary5
Pancreas4.55
PancreaticIslet5.85
ParietalLobe5.95
Pituitary6.25
Placenta5.4
Pons5.3
PrefrontalCortex6.4
Prostate6.15
Salivarygland4.5
SkeletalMuscle7.5
Skin4.9
SmoothMuscle6.05
Spinalcord5.65
SubthalamicNucleus5.05
SuperiorCervicalGanglion8.35
TemporalLobe5.1
Testis4.6
TestisGermCell4.6
TestisIntersitial4.7
TestisLeydigCell5.6
TestisSeminiferousTubule4.65
Thalamus5.65
Thymus4.1
Thyroid6.55
Tongue5.6
Tonsil5.35
Trachea4.4
TrigeminalGanglion6.7
Uterus4.25
UterusCorpus6.5
WholeBlood5.9
Wholebrain4.35
colon5.45
pineal_day6.6
pineal_night6.52
retina6.375
small_intestine5.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P39684
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.29 ± 0.42
Basal Forebrain6.29 ± 0.17
Basal Part of Pons6.47 ± 0.29
Cerebellar Cortex6.11 ± 0.28
Cerebellar Nuclei6.26 ± 0.42
Claustrum6.35 ± 0.61
Epithalamus6.4 ± 0.51
Frontal Lobe6.64 ± 0.4
Globus Pallidus5.98 ± 0.35
Hypothalamus6.27 ± 0.23
Insula6.53 ± 0.22
Limbic Lobe6.56 ± 0.55
Mesencephalon6.48 ± 0.4
Myelencephalon6.34 ± 0.43
Occipital Lobe6.31 ± 0.5
Parietal Lobe6.44 ± 0.43
Pontine Tegmentum6.34 ± 0.53
Striatum6.34 ± 0.47
Subthalamus6.36 ± 0.34
Temporal Lobe6.42 ± 0.32
Thalamus6.67 ± 0.46
White Matter5.76 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tlk1CBCerebellum33.33
64.83
Tlk1CTXCerebral cortex100
100
Tlk1HIPHippocampal region73.2
100
Tlk1HPFHippocampal formation78.77
100
Tlk1HYHypothalamus22.14
18.4
Tlk1LSXLateral septal complex38.97
33.57
Tlk1MBMidbrain36.72
36.07
Tlk1MYMedulla57.79
69.63
Tlk1OLFOlfactory bulb79.5
87.88
Tlk1PPons41.9
49.86
Tlk1PALPallidum31.64
30.43
Tlk1RHPRetrohippocampal region90.09
90.81
Tlk1sAMYStriatum-like amygdalar nuclei36.61
30
Tlk1STRStriatum89.43
78
Tlk1STRdStriatum dorsal region100
96.73
Tlk1STRvStriatum ventral region77.31
63.46
Tlk1THThalamus69.68
70.44
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00064159 17 644 660 ATEVQFPVKPVVSSEAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved