AutismKB 2.0

Annotation Detail for NUAK1


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Basic Information Top
Gene Symbol:NUAK1 ( ARK5,KIAA0537 )
Gene Full Name: NUAK family, SNF1-like kinase, 1
Band: 12q23.3
Quick LinksEntrez ID:9891; OMIM: 608130; Uniprot ID:NUAK1_HUMAN; ENSEMBL ID: ENSG00000074590; HGNC ID: 14311
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204589_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.55
Adipocyte63.2
AdrenalCortex8.7
Adrenalgland14.5
Amygdala115.05
Appendix10.35
AtrioventricularNode7.7
BDCA4+_DentriticCells4.85
Bonemarrow10
BronchialEpithelialCells21.9
CD105+_Endothelial4.5
CD14+_Monocytes5
CD19+_BCells(neg._sel.)4.75
CD33+_Myeloid5.65
CD34+5.6
CD4+_Tcells4.85
CD56+_NKCells9.85
CD71+_EarlyErythroid4.25
CD8+_Tcells4.3
CardiacMyocytes51.4
Caudatenucleus33.85
Cerebellum104.7
CerebellumPeduncles151.05
CiliaryGanglion6.95
CingulateCortex385.4
Colorectaladenocarcinoma36
DorsalRootGanglion10.85
FetalThyroid10.75
Fetalbrain94.7
Fetalliver7.95
Fetallung14.45
GlobusPallidus178.65
Heart20.7
Hypothalamus72.6
Kidney8.3
Leukemia_chronicMyelogenousK-5625.3
Leukemia_promyelocytic-HL-604
Leukemialymphoblastic(MOLT-4)4.95
Liver12.15
Lung54.45
Lymphnode9
Lymphoma_burkitts(Daudi)7.85
Lymphoma_burkitts(Raji)13.9
MedullaOblongata216.45
OccipitalLobe302.15
OlfactoryBulb20.15
Ovary12.2
Pancreas7.9
PancreaticIslet32.6
ParietalLobe445.15
Pituitary12.65
Placenta13.15
Pons175.1
PrefrontalCortex699.25
Prostate22.35
Salivarygland5.75
SkeletalMuscle11.9
Skin9.1
SmoothMuscle34.25
Spinalcord51.2
SubthalamicNucleus325.15
SuperiorCervicalGanglion11.75
TemporalLobe292.45
Testis7.45
TestisGermCell8.05
TestisIntersitial7.45
TestisLeydigCell10
TestisSeminiferousTubule9
Thalamus68.7
Thymus6.8
Thyroid11.15
Tongue9.9
Tonsil6.5
Trachea8.6
TrigeminalGanglion7.35
Uterus32.2
UterusCorpus10.5
WholeBlood8.1
Wholebrain463.55
colon9.85
pineal_day9.54
pineal_night9.58
retina26.625
small_intestine9.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7905_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.69 ± 0.57
Basal Forebrain7.25 ± 0.28
Basal Part of Pons8.26 ± 0.5
Cerebellar Cortex7.51 ± 0.31
Cerebellar Nuclei7.66 ± 0.26
Claustrum8.21 ± 0.44
Epithalamus6.84 ± 0.37
Frontal Lobe7.58 ± 0.52
Globus Pallidus6.68 ± 0.68
Hypothalamus7.33 ± 0.73
Insula7.52 ± 0.35
Limbic Lobe7.53 ± 0.42
Mesencephalon7.48 ± 0.47
Myelencephalon7.44 ± 0.51
Occipital Lobe7.87 ± 0.37
Parietal Lobe7.87 ± 0.47
Pontine Tegmentum7.37 ± 0.56
Striatum6.22 ± 0.66
Subthalamus7.53 ± 0.28
Temporal Lobe7.66 ± 0.41
Thalamus7.15 ± 0.56
White Matter7.16 ± 0.56
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nuak1CBCerebellum20.76
25.72
Nuak1CTXCerebral cortex28.98
22.8
Nuak1HIPHippocampal region16.28
19.02
Nuak1HPFHippocampal formation24.92
26.61
Nuak1HYHypothalamus16.32
12.48
Nuak1LSXLateral septal complex21.99
18.21
Nuak1MBMidbrain2.79
3.04
Nuak1MYMedulla20.89
23.65
Nuak1OLFOlfactory bulb28.71
28.54
Nuak1PPons15.47
16.89
Nuak1PALPallidum13.34
14.64
Nuak1RHPRetrohippocampal region38.88
36.6
Nuak1sAMYStriatum-like amygdalar nuclei32.25
34.94
Nuak1STRStriatum9.64
8.94
Nuak1STRdStriatum dorsal region2.3
1.74
Nuak1STRvStriatum ventral region22.01
20.46
Nuak1THThalamus3.97
3.21
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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