AutismKB 2.0

Annotation Detail for SRGAP3


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Basic Information Top
Gene Symbol:SRGAP3 ( ARHGAP14,KIAA0411,MEGAP,SRGAP2,WRP )
Gene Full Name: SLIT-ROBO Rho GTPase activating protein 3
Band: 3p25.3
Quick LinksEntrez ID:9901; OMIM: 606525; Uniprot ID:SRGP2_HUMAN; ENSEMBL ID: ENSG00000196220; HGNC ID: 19744
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus13 / 56401223
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult48 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma4 / 10688337
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal89 / 336030726
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain60 / 110098954
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine2 / 2344728
kidney1 / 2117774
larynx0 / 241450 
liver1 / 2077434
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle2 / 10771518
nerve1 / 1576863
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate7 / 18934536
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis9 / 33044227
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord1 / 1368073
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209794_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.1
Adipocyte3.35
AdrenalCortex3.45
Adrenalgland2.85
Amygdala8.7
Appendix3.4
AtrioventricularNode2.5
BDCA4+_DentriticCells3.8
Bonemarrow3.35
BronchialEpithelialCells3.35
CD105+_Endothelial3.45
CD14+_Monocytes3.6
CD19+_BCells(neg._sel.)3.6
CD33+_Myeloid4.3
CD34+4.4
CD4+_Tcells3.7
CD56+_NKCells4.1
CD71+_EarlyErythroid3.15
CD8+_Tcells3.25
CardiacMyocytes4.25
Caudatenucleus3.3
Cerebellum17.75
CerebellumPeduncles16.25
CiliaryGanglion2.35
CingulateCortex9.5
Colorectaladenocarcinoma3.4
DorsalRootGanglion2.5
FetalThyroid3.3
Fetalbrain19.3
Fetalliver3.2
Fetallung2.9
GlobusPallidus2.65
Heart4.3
Hypothalamus10.45
Kidney2.75
Leukemia_chronicMyelogenousK-5623.05
Leukemia_promyelocytic-HL-603
Leukemialymphoblastic(MOLT-4)2.75
Liver4.45
Lung3.75
Lymphnode2.95
Lymphoma_burkitts(Daudi)4.3
Lymphoma_burkitts(Raji)4.7
MedullaOblongata11.5
OccipitalLobe6.7
OlfactoryBulb2.7
Ovary2.25
Pancreas2.7
PancreaticIslet3.6
ParietalLobe8.05
Pituitary4
Placenta3.5
Pons3.45
PrefrontalCortex9.9
Prostate4.05
Salivarygland2.7
SkeletalMuscle3.75
Skin2.55
SmoothMuscle3.8
Spinalcord4.7
SubthalamicNucleus3.95
SuperiorCervicalGanglion3.8
TemporalLobe12.4
Testis3
TestisGermCell3.1
TestisIntersitial2.85
TestisLeydigCell3.35
TestisSeminiferousTubule2.95
Thalamus5.55
Thymus2.7
Thyroid4.35
Tongue3.25
Tonsil3.3
Trachea2.85
TrigeminalGanglion3.4
Uterus2.8
UterusCorpus3
WholeBlood3.75
Wholebrain16.45
colon3.4
pineal_day4.38
pineal_night4.56
retina4.175
small_intestine3.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7342_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.39 ± 0.52
Basal Forebrain5.85 ± 0.24
Basal Part of Pons5.89 ± 0.41
Cerebellar Cortex6.32 ± 0.21
Cerebellar Nuclei5.71 ± 0.42
Claustrum6.8 ± 0.52
Epithalamus5.5 ± 0.63
Frontal Lobe5.81 ± 0.43
Globus Pallidus5.66 ± 0.28
Hypothalamus5.49 ± 0.45
Insula5.99 ± 0.29
Limbic Lobe6.28 ± 0.43
Mesencephalon5.97 ± 0.48
Myelencephalon5.93 ± 0.49
Occipital Lobe6.47 ± 0.46
Parietal Lobe6.12 ± 0.42
Pontine Tegmentum5.99 ± 0.58
Striatum4.88 ± 0.38
Subthalamus5.48 ± 0.18
Temporal Lobe6.06 ± 0.39
Thalamus5.79 ± 0.4
White Matter5.25 ± 0.55
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Srgap3CBCerebellum100
100
Srgap3CTXCerebral cortex100
100
Srgap3HIPHippocampal region100
100
Srgap3HPFHippocampal formation100
100
Srgap3HYHypothalamus100
90.76
Srgap3LSXLateral septal complex97.76
87.84
Srgap3MBMidbrain93.86
89.37
Srgap3MYMedulla93.39
100
Srgap3OLFOlfactory bulb100
100
Srgap3PPons89.59
99.36
Srgap3PALPallidum91.65
89.36
Srgap3RHPRetrohippocampal region100
100
Srgap3sAMYStriatum-like amygdalar nuclei96.68
83.06
Srgap3STRStriatum87.76
76.76
Srgap3STRdStriatum dorsal region76.43
59.66
Srgap3STRvStriatum ventral region100
91.19
Srgap3THThalamus45.01
41.91
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00133506 14 661 674 TIIIHHEAIFPSPR Peptide Atlas
SRGP2_HUMAN_626 7 626 632 VVIVVMR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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