AutismKB 2.0

Annotation Detail for KLHL21


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Basic Information Top
Gene Symbol:KLHL21 ( KIAA0469,MGC99635 )
Gene Full Name: kelch-like 21 (Drosophila)
Band: 1p36.31
Quick LinksEntrez ID:9903; OMIM: NA; Uniprot ID:KLH21_HUMAN; ENSEMBL ID: ENSG00000162413; HGNC ID: 29041
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst4 / 6231964
fetus19 / 56401233
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult103 / 193912153
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma6 / 8282372
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor20 / 26384575
glioma6 / 10688356
head and neck tumor8 / 13630258
kidney tumor5 / 6895972
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor9 / 10312787
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal251 / 336030774
ovarian tumor4 / 7668252
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer2 / 10268019
retinoblastoma12 / 46356258
skin tumor41 / 124949328
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites0 / 400150 
bladder0 / 297570 
blood6 / 12347848
bone4 / 7165555
bone marrow1 / 4880120
brain154 / 1100989139
cervix2 / 4817141
connective tissue7 / 14925546
ear1 / 1621261
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye16 / 21105475
heart6 / 8962666
intestine5 / 23447221
kidney13 / 21177761
larynx0 / 241450 
liver8 / 20774338
lung20 / 33697459
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth8 / 67052119
muscle9 / 10771583
nerve0 / 157680 
ovary6 / 10205158
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta20 / 28082571
prostate16 / 18934584
salivary gland0 / 201550 
skin45 / 210574213
spleen0 / 539520 
stomach7 / 9661972
testis34 / 330442102
thymus6 / 8113173
thyroid3 / 4747363
tonsil0 / 169990 
trachea17 / 52413324
umbilical cord1 / 1368073
uterus23 / 23287898
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203068_at
Cell line Expression level Expression bar
721_B_lymphoblasts14.8
Adipocyte15.45
AdrenalCortex15
Adrenalgland15.65
Amygdala19.35
Appendix13.9
AtrioventricularNode10.6
BDCA4+_DentriticCells25.7
Bonemarrow15.1
BronchialEpithelialCells15.3
CD105+_Endothelial22.55
CD14+_Monocytes24.15
CD19+_BCells(neg._sel.)22.8
CD33+_Myeloid35.8
CD34+37.45
CD4+_Tcells18.25
CD56+_NKCells34.6
CD71+_EarlyErythroid26.6
CD8+_Tcells25.4
CardiacMyocytes11.6
Caudatenucleus16.35
Cerebellum13.1
CerebellumPeduncles17.3
CiliaryGanglion11
CingulateCortex16.75
Colorectaladenocarcinoma17.5
DorsalRootGanglion11.45
FetalThyroid7.8
Fetalbrain11.35
Fetalliver12.55
Fetallung10.3
GlobusPallidus11.15
Heart121.85
Hypothalamus17.05
Kidney16.9
Leukemia_chronicMyelogenousK-56213.9
Leukemia_promyelocytic-HL-6019
Leukemialymphoblastic(MOLT-4)11.55
Liver18.6
Lung33.45
Lymphnode9.95
Lymphoma_burkitts(Daudi)13.7
Lymphoma_burkitts(Raji)22.2
MedullaOblongata12.45
OccipitalLobe13.85
OlfactoryBulb16.25
Ovary6.9
Pancreas9.45
PancreaticIslet16.45
ParietalLobe14.7
Pituitary17.9
Placenta14.3
Pons14.55
PrefrontalCortex30.1
Prostate27
Salivarygland12
SkeletalMuscle22.15
Skin13.85
SmoothMuscle17.5
Spinalcord21.7
SubthalamicNucleus13.95
SuperiorCervicalGanglion13.45
TemporalLobe13.8
Testis13.25
TestisGermCell10.8
TestisIntersitial10
TestisLeydigCell11.8
TestisSeminiferousTubule12.15
Thalamus16.15
Thymus12.3
Thyroid18
Tongue11.8
Tonsil11.85
Trachea14.3
TrigeminalGanglion10.5
Uterus16.75
UterusCorpus12.5
WholeBlood47.25
Wholebrain13.8
colon10.45
pineal_day25.96
pineal_night25.46
retina62.425
small_intestine11
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P201478
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.24 ± 0.81
Basal Forebrain3.02 ± 0.6
Basal Part of Pons2.6 ± 0.71
Cerebellar Cortex2.85 ± 0.67
Cerebellar Nuclei3.31 ± 0.68
Claustrum3.43 ± 1.05
Epithalamus3.33 ± 0.45
Frontal Lobe2.9 ± 0.75
Globus Pallidus3.34 ± 0.62
Hypothalamus2.75 ± 0.65
Insula2.86 ± 0.6
Limbic Lobe3.14 ± 0.73
Mesencephalon3.22 ± 0.65
Myelencephalon3.11 ± 0.64
Occipital Lobe3.2 ± 0.64
Parietal Lobe3.14 ± 0.66
Pontine Tegmentum2.93 ± 0.72
Striatum3.06 ± 0.66
Subthalamus2.77 ± 0.67
Temporal Lobe3.02 ± 0.69
Thalamus2.85 ± 0.6
White Matter3.91 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Klhl21PPons0.7
0.41
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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