AutismKB 2.0

Annotation Detail for G3BP2


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Basic Information Top
Gene Symbol:G3BP2 ( - )
Gene Full Name: GTPase activating protein (SH3 domain) binding protein 2
Band: 4q21.1
Quick LinksEntrez ID:9908; OMIM: NA; Uniprot ID:G3BP2_HUMAN; ENSEMBL ID: ENSG00000138757; HGNC ID: 30291
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body17 / 70761240
blastocyst34 / 62319545
fetus68 / 564012120
neonate4 / 31097128
infant2 / 2362084
juvenile5 / 5555689
adult188 / 193912196
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor10 / 94178106
cervical tumor4 / 34366116
chondrosarcoma6 / 8282372
colorectal tumor19 / 114246166
esophageal tumor1 / 1729057
gastrointestinal tumor13 / 119369108
germ cell tumor28 / 263845106
glioma19 / 106883177
head and neck tumor18 / 136302132
kidney tumor6 / 6895987
leukemia12 / 95842125
liver tumor6 / 9635962
lung tumor4 / 10312738
lymphoma7 / 7175597
non-neoplasia8 / 9725082
normal429 / 3360307127
ovarian tumor9 / 76682117
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer6 / 10268058
retinoblastoma4 / 4635686
skin tumor36 / 124949288
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites4 / 4001599
bladder3 / 29757100
blood11 / 12347889
bone4 / 7165555
bone marrow7 / 48801143
brain188 / 1100989170
cervix4 / 4817183
connective tissue14 / 14925593
ear3 / 16212185
embryonic tissue62 / 215722287
esophagus2 / 2020998
eye12 / 21105456
heart4 / 8962644
intestine27 / 234472115
kidney29 / 211777136
larynx0 / 241450 
liver15 / 20774372
lung34 / 336974100
lymph6 / 44270135
lymph node13 / 91610141
mammary gland15 / 15327197
mouth4 / 6705259
muscle23 / 107715213
nerve3 / 15768190
ovary7 / 10205168
pancreas9 / 21481241
parathyroid2 / 2053997
pharynx4 / 4132896
pituitary gland1 / 1658560
placenta14 / 28082549
prostate16 / 18934584
salivary gland2 / 2015599
skin39 / 210574185
spleen3 / 5395255
stomach10 / 96619103
testis50 / 330442151
thymus12 / 81131147
thyroid14 / 47473294
tonsil4 / 16999235
trachea23 / 52413438
umbilical cord0 / 136800 
uterus35 / 232878150
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208840_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts224.25
Adipocyte34.3
AdrenalCortex24.2
Adrenalgland17.65
Amygdala73.95
Appendix24.65
AtrioventricularNode23.7
BDCA4+_DentriticCells209.45
Bonemarrow24.95
BronchialEpithelialCells119.65
CD105+_Endothelial47.4
CD14+_Monocytes126.3
CD19+_BCells(neg._sel.)182.9
CD33+_Myeloid117.05
CD34+83.4
CD4+_Tcells187.9
CD56+_NKCells175.85
CD71+_EarlyErythroid33.15
CD8+_Tcells185.5
CardiacMyocytes66.2
Caudatenucleus28.25
Cerebellum28.15
CerebellumPeduncles38.5
CiliaryGanglion21.1
CingulateCortex35.15
Colorectaladenocarcinoma34.7
DorsalRootGanglion24.9
FetalThyroid26.5
Fetalbrain50.8
Fetalliver46.4
Fetallung26.3
GlobusPallidus29.15
Heart38.7
Hypothalamus37.05
Kidney21.8
Leukemia_chronicMyelogenousK-56217.8
Leukemia_promyelocytic-HL-6032.2
Leukemialymphoblastic(MOLT-4)70.95
Liver36.05
Lung22.8
Lymphnode27.65
Lymphoma_burkitts(Daudi)55.95
Lymphoma_burkitts(Raji)42.75
MedullaOblongata22.65
OccipitalLobe84.55
OlfactoryBulb12.6
Ovary26.5
Pancreas19.25
PancreaticIslet114.35
ParietalLobe36.2
Pituitary35.55
Placenta35.35
Pons27.2
PrefrontalCortex39.2
Prostate42.15
Salivarygland27.9
SkeletalMuscle37.9
Skin27.75
SmoothMuscle112.95
Spinalcord21.25
SubthalamicNucleus34.55
SuperiorCervicalGanglion37.1
TemporalLobe22.75
Testis12.8
TestisGermCell29.05
TestisIntersitial27.7
TestisLeydigCell35.75
TestisSeminiferousTubule17.65
Thalamus25.65
Thymus26.65
Thyroid43.75
Tongue26.85
Tonsil41.45
Trachea47.85
TrigeminalGanglion24.2
Uterus24.5
UterusCorpus27.45
WholeBlood67.5
Wholebrain35.4
colon169.2
pineal_day45.48
pineal_night51.82
retina35.4
small_intestine95.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P41255
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.81 ± 0.38
Basal Forebrain9.77 ± 0.18
Basal Part of Pons10.17 ± 0.24
Cerebellar Cortex9.8 ± 0.22
Cerebellar Nuclei9.99 ± 0.36
Claustrum10.08 ± 0.29
Epithalamus9.44 ± 0.43
Frontal Lobe9.94 ± 0.35
Globus Pallidus9.16 ± 0.33
Hypothalamus10.23 ± 0.26
Insula9.98 ± 0.23
Limbic Lobe10.04 ± 0.41
Mesencephalon9.97 ± 0.39
Myelencephalon9.88 ± 0.4
Occipital Lobe10.35 ± 0.29
Parietal Lobe10.06 ± 0.35
Pontine Tegmentum9.97 ± 0.35
Striatum9.63 ± 0.38
Subthalamus10.44 ± 0.29
Temporal Lobe9.92 ± 0.27
Thalamus9.88 ± 0.25
White Matter9.01 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
E430034L04RikCBCerebellum51.28
94.37
E430034L04RikCTXCerebral cortex100
100
E430034L04RikHIPHippocampal region100
100
E430034L04RikHPFHippocampal formation100
100
E430034L04RikHYHypothalamus100
100
E430034L04RikLSXLateral septal complex100
100
E430034L04RikMBMidbrain100
100
E430034L04RikMYMedulla100
100
E430034L04RikOLFOlfactory bulb100
100
E430034L04RikPPons100
100
E430034L04RikPALPallidum100
100
E430034L04RikRHPRetrohippocampal region100
100
E430034L04RiksAMYStriatum-like amygdalar nuclei100
100
E430034L04RikSTRStriatum100
100
E430034L04RikSTRdStriatum dorsal region100
100
E430034L04RikSTRvStriatum ventral region100
100
E430034L04RikTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
G3BP2_HUMAN_124 9 124 132 FYVHNDMFR PRIDE
G3BP2_HUMAN_18 15 18 32 QYYTLLNKAPEYLHR PRIDE
G3BP2_HUMAN_27 6 27 32 PEYLHR PRIDE
G3BP2_HUMAN_298 8 298 305 ERPGFPPR PRIDE
G3BP2_HUMAN_3 11 3 13 MEKPSPLLVGR PRIDE
G3BP2_HUMAN_79 28 79 106 HVDAHATLSDGVVVQVMGLLSNSGQPER PRIDE
PAp00008451 12 65 76 VLSLNFSECHTK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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