AutismKB 2.0

Annotation Detail for PAN2


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Basic Information Top
Gene Symbol:PAN2 ( FLJ39360,KIAA0710,USP52 )
Gene Full Name: PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
Band: 12q13.3
Quick LinksEntrez ID:9924; OMIM: NA; Uniprot ID:PAN2_HUMAN; ENSEMBL ID: ENSG00000135473; HGNC ID: 20074
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst7 / 62319112
fetus31 / 56401254
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult98 / 193912150
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma7 / 8282384
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor12 / 26384545
glioma3 / 10688328
head and neck tumor17 / 136302124
kidney tumor2 / 6895929
leukemia9 / 9584293
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal178 / 336030752
ovarian tumor1 / 7668213
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma3 / 4635664
skin tumor6 / 12494948
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood14 / 123478113
bone6 / 7165583
bone marrow0 / 488010 
brain68 / 110098961
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye7 / 21105433
heart7 / 8962678
intestine8 / 23447234
kidney7 / 21177733
larynx2 / 2414582
liver7 / 20774333
lung14 / 33697441
lymph1 / 4427022
lymph node11 / 91610120
mammary gland9 / 15327158
mouth8 / 67052119
muscle8 / 10771574
nerve1 / 1576863
ovary2 / 10205119
pancreas20 / 21481293
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta5 / 28082517
prostate4 / 18934521
salivary gland0 / 201550 
skin10 / 21057447
spleen2 / 5395237
stomach5 / 9661951
testis47 / 330442142
thymus2 / 8113124
thyroid9 / 47473189
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209796_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts108.45
Adipocyte68.25
AdrenalCortex30.65
Adrenalgland28.3
Amygdala48.4
Appendix23.55
AtrioventricularNode22.35
BDCA4+_DentriticCells58.7
Bonemarrow28.5
BronchialEpithelialCells73.85
CD105+_Endothelial29.9
CD14+_Monocytes33.55
CD19+_BCells(neg._sel.)39.75
CD33+_Myeloid39.8
CD34+53.3
CD4+_Tcells32
CD56+_NKCells49.15
CD71+_EarlyErythroid16.35
CD8+_Tcells35.65
CardiacMyocytes64.9
Caudatenucleus30.4
Cerebellum24.8
CerebellumPeduncles33.9
CiliaryGanglion13.85
CingulateCortex30.9
Colorectaladenocarcinoma138.25
DorsalRootGanglion19.9
FetalThyroid33.5
Fetalbrain29
Fetalliver26.1
Fetallung28.5
GlobusPallidus19.6
Heart38.65
Hypothalamus56.4
Kidney26.5
Leukemia_chronicMyelogenousK-56238.25
Leukemia_promyelocytic-HL-6026.05
Leukemialymphoblastic(MOLT-4)60.9
Liver65.25
Lung49.65
Lymphnode26.25
Lymphoma_burkitts(Daudi)42.1
Lymphoma_burkitts(Raji)41.4
MedullaOblongata30.45
OccipitalLobe33.6
OlfactoryBulb23.15
Ovary17
Pancreas25.2
PancreaticIslet60.3
ParietalLobe33.6
Pituitary158.6
Placenta150.4
Pons26.4
PrefrontalCortex39.85
Prostate83.55
Salivarygland24.15
SkeletalMuscle34.3
Skin15.35
SmoothMuscle117.1
Spinalcord32.25
SubthalamicNucleus27.2
SuperiorCervicalGanglion33
TemporalLobe29.5
Testis23.25
TestisGermCell26.85
TestisIntersitial23.1
TestisLeydigCell27.65
TestisSeminiferousTubule19.55
Thalamus37.1
Thymus27.35
Thyroid85.5
Tongue28.15
Tonsil25.8
Trachea39.9
TrigeminalGanglion19.45
Uterus34.85
UterusCorpus36.6
WholeBlood33
Wholebrain134.9
colon54.05
pineal_day67.54
pineal_night58.8
retina40.85
small_intestine58.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P64689
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.31 ± 0.54
Basal Forebrain4.82 ± 0.35
Basal Part of Pons4.96 ± 0.22
Cerebellar Cortex5.23 ± 0.29
Cerebellar Nuclei4.87 ± 0.51
Claustrum3.9 ± 0.75
Epithalamus5.16 ± 0.42
Frontal Lobe4.58 ± 0.57
Globus Pallidus4.96 ± 0.57
Hypothalamus4.65 ± 0.57
Insula4.49 ± 0.36
Limbic Lobe4.38 ± 0.53
Mesencephalon4.75 ± 0.6
Myelencephalon4.72 ± 0.53
Occipital Lobe5.07 ± 0.43
Parietal Lobe4.64 ± 0.52
Pontine Tegmentum4.69 ± 0.63
Striatum4.77 ± 0.52
Subthalamus4.94 ± 0.42
Temporal Lobe4.64 ± 0.43
Thalamus4.81 ± 0.46
White Matter6.19 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Usp52CBCerebellum13.19
11.61
Usp52CTXCerebral cortex1.55
1.08
Usp52HIPHippocampal region3.7
3.26
Usp52HPFHippocampal formation2.63
2.16
Usp52HYHypothalamus0.46
0.34
Usp52LSXLateral septal complex0.07
0.03
Usp52MBMidbrain1.34
1.35
Usp52MYMedulla5.97
5.97
Usp52OLFOlfactory bulb2.42
2.74
Usp52PPons2.84
2.61
Usp52PALPallidum1.83
1.47
Usp52RHPRetrohippocampal region0.87
0.67
Usp52sAMYStriatum-like amygdalar nuclei1.77
1.09
Usp52STRStriatum1.16
0.95
Usp52STRdStriatum dorsal region0.66
0.6
Usp52STRvStriatum ventral region3.49
2.68
Usp52THThalamus1.8
1.27
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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