AutismKB 2.0

Annotation Detail for WDR1


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Basic Information Top
Gene Symbol:WDR1 ( AIP1,NORI-1 )
Gene Full Name: WD repeat domain 1
Band: 4p16.1
Quick LinksEntrez ID:9948; OMIM: 604734; Uniprot ID:WDR1_HUMAN; ENSEMBL ID: ENSG00000071127; HGNC ID: 12754
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body29 / 70761409
blastocyst14 / 62319224
fetus89 / 564012157
neonate27 / 31097868
infant6 / 23620254
juvenile22 / 55556395
adult496 / 1939121255
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor27 / 94178286
cervical tumor6 / 34366174
chondrosarcoma37 / 82823446
colorectal tumor51 / 114246446
esophageal tumor3 / 17290173
gastrointestinal tumor42 / 119369351
germ cell tumor106 / 263845401
glioma35 / 106883327
head and neck tumor40 / 136302293
kidney tumor21 / 68959304
leukemia29 / 95842302
liver tumor20 / 96359207
lung tumor30 / 103127290
lymphoma14 / 71755195
non-neoplasia40 / 97250411
normal878 / 3360307261
ovarian tumor24 / 76682312
pancreatic tumor31 / 104616296
primitive neuroectodermal tumor of the CNS30 / 125680238
prostate cancer13 / 102680126
retinoblastoma4 / 4635686
skin tumor38 / 124949304
soft tissue/muscle tissue tumor23 / 125191183
uterine tumor19 / 90257210
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland1 / 3319730
ascites7 / 40015174
bladder8 / 29757268
blood43 / 123478348
bone15 / 71655209
bone marrow9 / 48801184
brain261 / 1100989237
cervix9 / 48171186
connective tissue55 / 149255368
ear2 / 16212123
embryonic tissue62 / 215722287
esophagus4 / 20209197
eye39 / 211054184
heart14 / 89626156
intestine99 / 234472422
kidney135 / 211777637
larynx3 / 24145124
liver31 / 207743149
lung88 / 336974261
lymph10 / 44270225
lymph node10 / 91610109
mammary gland34 / 153271221
mouth17 / 67052253
muscle7 / 10771564
nerve4 / 15768253
ovary26 / 102051254
pancreas37 / 214812172
parathyroid3 / 20539146
pharynx4 / 4132896
pituitary gland2 / 16585120
placenta50 / 280825178
prostate26 / 189345137
salivary gland3 / 20155148
skin128 / 210574607
spleen28 / 53952518
stomach35 / 96619362
testis86 / 330442260
thymus60 / 81131739
thyroid29 / 47473610
tonsil10 / 16999588
trachea17 / 52413324
umbilical cord4 / 13680292
uterus72 / 232878309
vascular50 / 51780965
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200611_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1349.15
Adipocyte336.5
AdrenalCortex128.8
Adrenalgland121.2
Amygdala184.75
Appendix30.45
AtrioventricularNode27.95
BDCA4+_DentriticCells1313.65
Bonemarrow327.1
BronchialEpithelialCells916.1
CD105+_Endothelial148.9
CD14+_Monocytes905.35
CD19+_BCells(neg._sel.)517.25
CD33+_Myeloid873.6
CD34+584.55
CD4+_Tcells896.25
CD56+_NKCells1637.4
CD71+_EarlyErythroid134.6
CD8+_Tcells919.85
CardiacMyocytes1304.55
Caudatenucleus47.55
Cerebellum31
CerebellumPeduncles92.1
CiliaryGanglion49.05
CingulateCortex54.4
Colorectaladenocarcinoma356.1
DorsalRootGanglion55.25
FetalThyroid275.1
Fetalbrain150.75
Fetalliver151.5
Fetallung410.5
GlobusPallidus10.6
Heart295.9
Hypothalamus135.6
Kidney209.25
Leukemia_chronicMyelogenousK-562106.85
Leukemia_promyelocytic-HL-60169.55
Leukemialymphoblastic(MOLT-4)651.9
Liver288.4
Lung783.4
Lymphnode258.1
Lymphoma_burkitts(Daudi)248.5
Lymphoma_burkitts(Raji)349.5
MedullaOblongata37.9
OccipitalLobe83.25
OlfactoryBulb185.5
Ovary112.25
Pancreas133.1
PancreaticIslet166.15
ParietalLobe69.35
Pituitary136.75
Placenta507.2
Pons69.85
PrefrontalCortex134.65
Prostate451.9
Salivarygland135.1
SkeletalMuscle111.45
Skin51.7
SmoothMuscle1650.5
Spinalcord116.4
SubthalamicNucleus40.95
SuperiorCervicalGanglion50.3
TemporalLobe38.8
Testis621.55
TestisGermCell604.15
TestisIntersitial757.2
TestisLeydigCell470.55
TestisSeminiferousTubule460.95
Thalamus82.15
Thymus560.85
Thyroid729.75
Tongue117.15
Tonsil325.9
Trachea217.8
TrigeminalGanglion68.6
Uterus516.2
UterusCorpus186.45
WholeBlood1130.55
Wholebrain152.45
colon757.7
pineal_day583.82
pineal_night529.32
retina345.85
small_intestine567.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P106145
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.78 ± 0.52
Basal Forebrain8.32 ± 0.27
Basal Part of Pons7.66 ± 0.29
Cerebellar Cortex7.92 ± 0.31
Cerebellar Nuclei8.19 ± 0.43
Claustrum8.49 ± 0.76
Epithalamus8.56 ± 0.4
Frontal Lobe8.16 ± 0.36
Globus Pallidus9.14 ± 0.29
Hypothalamus8.36 ± 0.32
Insula8.18 ± 0.33
Limbic Lobe8.84 ± 0.47
Mesencephalon8.36 ± 0.41
Myelencephalon8.4 ± 0.43
Occipital Lobe8.81 ± 0.64
Parietal Lobe8.16 ± 0.41
Pontine Tegmentum8.41 ± 0.38
Striatum8.17 ± 0.52
Subthalamus8 ± 0.1
Temporal Lobe8.36 ± 0.41
Thalamus8.1 ± 0.35
White Matter9.1 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wdr1CBCerebellum27.02
40.9
Wdr1CTXCerebral cortex62.69
56.39
Wdr1HIPHippocampal region60.16
100
Wdr1HPFHippocampal formation66.78
100
Wdr1HYHypothalamus32.25
30.87
Wdr1LSXLateral septal complex40.93
39.79
Wdr1MBMidbrain23.1
25.87
Wdr1MYMedulla36.1
46.77
Wdr1OLFOlfactory bulb51.12
48.04
Wdr1PPons34.21
43.11
Wdr1PALPallidum33.41
37.36
Wdr1RHPRetrohippocampal region79.16
81.71
Wdr1sAMYStriatum-like amygdalar nuclei30.02
27.89
Wdr1STRStriatum13.82
14.08
Wdr1STRdStriatum dorsal region6.97
9.03
Wdr1STRvStriatum ventral region15.23
12.3
Wdr1THThalamus18.97
19.87
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000974 33 298 330 CFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVR Peptide Atlas
WDR1_HUMAN_0 0 0 0 FATASADGQIYIYDGK PRIDE
WDR1_HUMAN_0 0 0 0 FGAVFLWDSGSSVGEITGHNK PRIDE
WDR1_HUMAN_0 0 0 0 GPVTDVAYSHDGAFLAVCDASK PRIDE
WDR1_HUMAN_0 0 0 0 KCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVR PRIDE
WDR1_HUMAN_0 0 0 0 LHHVSSLAWLDEHTLVTTSHDASVK PRIDE
WDR1_HUMAN_0 0 0 0 LYSILGTTLKDEGK PRIDE
WDR1_HUMAN_0 0 0 0 SYIYSGSHDGHINYWDSETGENDSFAGK PRIDE
WDR1_HUMAN_0 0 0 0 VVTVFSVADGYSENNVFYGHHAK PRIDE
WDR1_HUMAN_0 0 0 0 YAPSGFYIASGDVSGK PRIDE
WDR1_HUMAN_1 16 1 16 PYEIKKVFASLPQVER PRIDE
WDR1_HUMAN_106 10 106 115 DIAWTEDSKR PRIDE
WDR1_HUMAN_126 21 126 146 FGAVFLWDSGSSVGEITGHNK PRIDE
WDR1_HUMAN_147 8 147 154 VINSVDIK PRIDE
WDR1_HUMAN_161 19 161 179 LATGSDDNCAAFFEGPPFK PRIDE
WDR1_HUMAN_161 21 161 181 LATGSDDNCAAFFEGPPFKFK PRIDE
WDR1_HUMAN_2 16 2 17 PYEIKKVFASLPQVER PRIDE
WDR1_HUMAN_231 25 231 255 AHDGGIYAISWSPDSTHLLSASGDK PRIDE
WDR1_HUMAN_231 28 231 258 AHDGGIYAISWSPDSTHLLSASGDKTSK PRIDE
WDR1_HUMAN_334 28 334 361 SYIYSGSHDGHINYWDSETGENDSFAGK PRIDE
WDR1_HUMAN_389 7 389 395 YTSLMLR PRIDE
WDR1_HUMAN_43 22 43 64 NIDNPALADIYTEHAHQVVVAK PRIDE
WDR1_HUMAN_470 14 470 483 LYSILGTTLKDEGK PRIDE
WDR1_HUMAN_489 22 489 510 GPVTDVAYSHDGAFLAVCDASK PRIDE
WDR1_HUMAN_511 23 511 533 VVTVFSVADGYSENNVFYGHHAK PRIDE
WDR1_HUMAN_575 25 575 599 LHHVSSLAWLDEHTLVTTSHDASVK PRIDE
WDR1_HUMAN_6 11 6 16 KVFASLPQVER PRIDE
WDR1_HUMAN_65 16 65 80 YAPSGFYIASGDVSGK PRIDE
WDR1_HUMAN_7 10 7 16 VFASLPQVER PRIDE
WDR1_HUMAN_83 12 83 94 IWDTTQKEHLLK PRIDE
WDR1_HUMAN_95 9 95 103 YEYQPFAGK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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