AutismKB 2.0

Annotation Detail for USP3


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Basic Information Top
Gene Symbol:USP3 ( MGC129878,MGC129879,SIH003,UBP )
Gene Full Name: ubiquitin specific peptidase 3
Band: 15q22.3
Quick LinksEntrez ID:9960; OMIM: 604728; Uniprot ID:UBP3_HUMAN; ENSEMBL ID: ENSG00000140455; HGNC ID: 12626
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus63 / 564012111
neonate2 / 3109764
infant2 / 2362084
juvenile10 / 55556179
adult116 / 193912159
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor3 / 3436687
chondrosarcoma5 / 8282360
colorectal tumor8 / 11424670
esophageal tumor2 / 17290115
gastrointestinal tumor6 / 11936950
germ cell tumor25 / 26384594
glioma5 / 10688346
head and neck tumor12 / 13630288
kidney tumor1 / 6895914
leukemia11 / 95842114
liver tumor2 / 9635920
lung tumor7 / 10312767
lymphoma3 / 7175541
non-neoplasia7 / 9725071
normal245 / 336030772
ovarian tumor6 / 7668278
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer6 / 10268058
retinoblastoma4 / 4635686
skin tumor4 / 12494932
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland3 / 3319790
ascites2 / 4001549
bladder5 / 29757168
blood22 / 123478178
bone4 / 7165555
bone marrow3 / 4880161
brain90 / 110098981
cervix3 / 4817162
connective tissue13 / 14925587
ear4 / 16212246
embryonic tissue6 / 21572227
esophagus2 / 2020998
eye13 / 21105461
heart3 / 8962633
intestine20 / 23447285
kidney15 / 21177770
larynx1 / 2414541
liver7 / 20774333
lung28 / 33697483
lymph0 / 442700 
lymph node4 / 9161043
mammary gland10 / 15327165
mouth6 / 6705289
muscle3 / 10771527
nerve1 / 1576863
ovary7 / 10205168
pancreas7 / 21481232
parathyroid3 / 20539146
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta8 / 28082528
prostate14 / 18934573
salivary gland2 / 2015599
skin7 / 21057433
spleen8 / 53952148
stomach7 / 9661972
testis34 / 330442102
thymus14 / 81131172
thyroid4 / 4747384
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus15 / 23287864
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221654_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts150.6
Adipocyte6.9
AdrenalCortex6
Adrenalgland5.45
Amygdala6.1
Appendix6.65
AtrioventricularNode4.8
BDCA4+_DentriticCells138.3
Bonemarrow16.3
BronchialEpithelialCells32.05
CD105+_Endothelial54
CD14+_Monocytes362.15
CD19+_BCells(neg._sel.)197.15
CD33+_Myeloid546.55
CD34+97.3
CD4+_Tcells145.35
CD56+_NKCells135.75
CD71+_EarlyErythroid7.6
CD8+_Tcells155.75
CardiacMyocytes8.3
Caudatenucleus5.4
Cerebellum5.15
CerebellumPeduncles6.9
CiliaryGanglion4.3
CingulateCortex6.45
Colorectaladenocarcinoma6.8
DorsalRootGanglion4.7
FetalThyroid6.45
Fetalbrain8.95
Fetalliver5.65
Fetallung30.75
GlobusPallidus4.15
Heart7.3
Hypothalamus6.7
Kidney4.9
Leukemia_chronicMyelogenousK-5626.9
Leukemia_promyelocytic-HL-6022.55
Leukemialymphoblastic(MOLT-4)23.4
Liver7.6
Lung11.85
Lymphnode39.45
Lymphoma_burkitts(Daudi)18.9
Lymphoma_burkitts(Raji)43.85
MedullaOblongata5.3
OccipitalLobe5.2
OlfactoryBulb5.05
Ovary4.55
Pancreas16.15
PancreaticIslet19.4
ParietalLobe6.05
Pituitary6.75
Placenta9.9
Pons5.45
PrefrontalCortex7.45
Prostate19.1
Salivarygland11.8
SkeletalMuscle6.6
Skin5.25
SmoothMuscle8.55
Spinalcord6.65
SubthalamicNucleus5.1
SuperiorCervicalGanglion7.2
TemporalLobe5.25
Testis11.35
TestisGermCell5.95
TestisIntersitial5.8
TestisLeydigCell6.5
TestisSeminiferousTubule6.15
Thalamus6.2
Thymus11.35
Thyroid10.4
Tongue6.6
Tonsil10.2
Trachea6.75
TrigeminalGanglion5.95
Uterus16.1
UterusCorpus5.6
WholeBlood245.1
Wholebrain4.9
colon73.35
pineal_day7.68
pineal_night7.38
retina10.75
small_intestine56.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P3602
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.23 ± 0.26
Basal Forebrain5.4 ± 0.53
Basal Part of Pons4.92 ± 0.44
Cerebellar Cortex5.66 ± 0.37
Cerebellar Nuclei4.98 ± 0.35
Claustrum4.48 ± 0.66
Epithalamus5.06 ± 0.5
Frontal Lobe4.79 ± 0.43
Globus Pallidus5.66 ± 0.91
Hypothalamus4.9 ± 0.58
Insula4.82 ± 0.33
Limbic Lobe4.87 ± 0.48
Mesencephalon4.95 ± 0.58
Myelencephalon5.02 ± 0.54
Occipital Lobe5.41 ± 0.56
Parietal Lobe4.92 ± 0.47
Pontine Tegmentum5.08 ± 0.61
Striatum5.33 ± 0.84
Subthalamus4.58 ± 0.45
Temporal Lobe4.83 ± 0.42
Thalamus5.14 ± 0.49
White Matter5.6 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Usp3CBCerebellum100
100
Usp3CTXCerebral cortex73.64
54.35
Usp3HIPHippocampal region52.53
75.56
Usp3HPFHippocampal formation69.37
78.42
Usp3HYHypothalamus7.35
5.12
Usp3LSXLateral septal complex32.66
26.53
Usp3MBMidbrain6.66
5.66
Usp3MYMedulla11.24
11.91
Usp3OLFOlfactory bulb81.52
70.33
Usp3PPons13.61
13.45
Usp3PALPallidum18.96
15.37
Usp3RHPRetrohippocampal region94.52
82.81
Usp3sAMYStriatum-like amygdalar nuclei31.65
22.47
Usp3STRStriatum100
88.75
Usp3STRdStriatum dorsal region100
100
Usp3STRvStriatum ventral region100
85.35
Usp3THThalamus17.36
13.58
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00042497 18 370 387 SFTDLEELDETELYMCHK Peptide Atlas
UBP3_HUMAN_197 8 197 204 NGKTAGRR PRIDE
UBP3_HUMAN_210 14 210 223 SQGDNNVSLVEEFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018