AutismKB 2.0

Annotation Detail for HDAC6


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Basic Information Top
Gene Symbol:HDAC6 ( FLJ16239,HD6 )
Gene Full Name: histone deacetylase 6
Band: Xp11.23
Quick LinksEntrez ID:10013; OMIM: 300272; Uniprot ID:HDAC6_HUMAN; ENSEMBL ID: ENSG00000094631; HGNC ID: 14064
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
16Phosphoserine (By similarity).
22Phosphoserine.
30Phosphothreonine.
Location(AA) Modifications Resource
22Phosphoserine.Swiss-Prot 53.0
22PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
16Phosphoserine(PKG)HMM predict
22Phosphoserine(ATM)HMM predict
28Phosphoserine(IKK)HMM predict
149SulfotyrosineHMM predict
158Phosphotyrosine(INSR)HMM predict
158Phosphotyrosine(Syk)HMM predict
158Phosphotyrosine(SRC)HMM predict
171Phosphotyrosine(Syk)HMM predict
175Phosphotyrosine(Syk)HMM predict
291N-linkedHMM predict
319Phosphotyrosine(EGFR)HMM predict
458Phosphoserine(CK1)HMM predict
458PhosphoserineHMM predict
564Phosphoserine(PKB)HMM predict
570Phosphotyrosine(EGFR)HMM predict
570Phosphotyrosine(INSR)HMM predict
654N-linkedHMM predict
783N-linkedHMM predict
788O-linkedHMM predict
807Phosphothreonine(PKC)HMM predict
814O-linkedHMM predict
852Phosphothreonine(PKC)HMM predict
868Phosphothreonine(PKC)HMM predict
869Phosphothreonine(PKC)HMM predict
892Phosphothreonine(MAPK)HMM predict
919O-linkedHMM predict
947Phosphothreonine(MAPK)HMM predict
953O-linkedHMM predict
1031Phosphothreonine(MAPK)HMM predict
1035O-linkedHMM predict
1041Phosphothreonine(MAPK)HMM predict
1045O-linkedHMM predict
1062Phosphoserine(ATM)HMM predict
1068Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006044
  • Location:chrX 48545430-48568323
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 48544539 48545928 1389 197
ETS1 JurkatGSE17954 48544340 48545514 1174 504
Gata2 K562GSE18868 48543678 48544714 1036 1235
Rb GrowingGSE19898 48544658 48545113 455 545
Rb QuiescentGSE19898 48544639 48545335 696 444
Rb SenescentGSE19898 48544526 48545206 680 565
Rb shRbQuiescentGSE19898 48544679 48545030 351 576
Rb shRbSenescenceGSE19898 48544588 48545086 498 594
hScc1 BcellGSE12603 48544197 48545050 853 807
hScc1 G2GSE9613 48544539 48545127 588 598
p130 QuiescentGSE19898 48544653 48545004 351 602
p130 SenescentGSE19898 48544628 48545055 427 589
p130 shRbQuiescentGSE19898 48544369 48544955 586 769
p130 shRbSenescentGSE19898 48544483 48545104 621 637
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 48569580 48569702 122 1318
CTCF CD4SISSRdata 48569580 48569702 122 1318
hScc1 BcellGSE12603 48569365 48570779 1414 1749
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 48549282 48549806 524 0
CTCF G2GSE9613 48551467 48551683 216 0
CTCF G2GSE9613 48558079 48558966 887 0
CTCF G2GSE9613 48559388 48559723 335 0
CTCF G2GSE9613 48561505 48561704 199 0
CTCF G2GSE9613 48562144 48562395 251 0
CTCF G2GSE9613 48566394 48566850 456 0
H3ac HepG2E 48545443 48546617 1174 0
Oct1 H2O2-HelaGSE14283 48554739 48554793 54 0
Oct1 HelaGSE14283 48554739 48554793 54 0
Oct1 HelaGSE14283 48564683 48564722 39 0
PHF8 293TGSE20725 48545233 48546118 885 0
TFAP2C MCF7GSE21234 48545413 48546019 606 0
hScc1 BcellGSE12603 48558118 48559006 888 0
hScc1 G2GSE9613 48545785 48546167 382 0
hScc1 G2GSE9613 48549499 48549806 307 0
hScc1 G2GSE9613 48557759 48559006 1247 0
hScc1 G2GSE9613 48559388 48559723 335 0
hScc1 G2GSE9613 48566394 48566805 411 0
p130 SenescentGSE19898 48545593 48545883 290 0
p130 shRbQuiescentGSE19898 48545522 48545848 326 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-433 hsa-mir-433 14 21118135
hsa-miR-433 hsa-mir-433 14 20181727
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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