AutismKB 2.0

Annotation Detail for HCN4


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Basic Information Top
Gene Symbol:HCN4 ( SSS2 )
Gene Full Name: hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Band: 15q24.1
Quick LinksEntrez ID:10021; OMIM: 605206; Uniprot ID:HCN4_HUMAN; ENSEMBL ID: ENSG00000138622; HGNC ID: 16882
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
458N-linked (GlcNAc...) (Potential).
935Phosphoserine (By similarity).
Location(AA) Modifications Resource
458N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
935Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
14Phosphoserine(CAMK2)HMM predict
14Phosphoserine(CK1)HMM predict
14Phosphoserine(IKK)HMM predict
55O-linkedHMM predict
55Phosphoserine(CDC2)HMM predict
55Phosphoserine(MAPK)HMM predict
55Phosphoserine(CDK)HMM predict
57O-linkedHMM predict
57Phosphoserine(CDC2)HMM predict
57Phosphoserine(CDK)HMM predict
59O-linkedHMM predict
59O-linkedHMM predict
70Phosphoserine(CK1)HMM predict
115O-linkedHMM predict
138Phosphoserine(ATM)HMM predict
144Phosphothreonine(MAPK)HMM predict
158O-linkedHMM predict
164O-linkedHMM predict
164Phosphoserine(CDC2)HMM predict
164Phosphoserine(MAPK)HMM predict
164Phosphoserine(CDK)HMM predict
164Phosphoserine(ATM)HMM predict
178Phosphoserine(IKK)HMM predict
291N-linkedHMM predict
293Phosphothreonine(CDC2)HMM predict
368Phosphotyrosine(Syk)HMM predict
370Phosphothreonine(PKC)HMM predict
429S-palmitoylHMM predict
522Phosphoserine(CK1)HMM predict
522Phosphoserine(CDK)HMM predict
531Phosphotyrosine(Syk)HMM predict
555Phosphotyrosine(Syk)HMM predict
559SulfotyrosineHMM predict
672Phosphoserine(CAMK2)HMM predict
672Phosphoserine(PKB)HMM predict
764O-linkedHMM predict
766O-linkedHMM predict
766O-linkedHMM predict
766Phosphothreonine(MAPK)HMM predict
768Phosphothreonine(MAPK)HMM predict
770O-linkedHMM predict
790O-linkedHMM predict
822Phosphothreonine(PKC)HMM predict
822Phosphothreonine(MAPK)HMM predict
822Phosphothreonine(CDK)HMM predict
831Phosphoserine(PKA)HMM predict
831PhosphoserineHMM predict
841O-linkedHMM predict
841Phosphoserine(CDC2)HMM predict
841Phosphoserine(CDK)HMM predict
841Phosphoserine(IKK)HMM predict
844O-linkedHMM predict
844Phosphoserine(IKK)HMM predict
845O-linkedHMM predict
845Phosphoserine(CDC2)HMM predict
845PhosphoserineHMM predict
847Phosphoserine(ATM)HMM predict
847Phosphoserine(IKK)HMM predict
851O-linkedHMM predict
851Phosphothreonine(MAPK)HMM predict
854O-linkedHMM predict
877O-linkedHMM predict
879O-linkedHMM predict
880O-linkedHMM predict
881O-linkedHMM predict
881Phosphoserine(ATM)HMM predict
889O-linkedHMM predict
889Phosphoserine(CDC2)HMM predict
889Phosphoserine(IKK)HMM predict
889PhosphoserineHMM predict
891O-linkedHMM predict
891O-linkedHMM predict
894Phosphothreonine(MAPK)HMM predict
896O-linkedHMM predict
917Phosphoserine(IKK)HMM predict
921Phosphoserine(ATM)HMM predict
923Phosphoserine(IKK)HMM predict
927Phosphothreonine(MAPK)HMM predict
935Phosphoserine(CDC2)HMM predict
942O-linkedHMM predict
942Phosphoserine(IKK)HMM predict
949MethylarginineHMM predict
964O-linkedHMM predict
965O-linkedHMM predict
967Phosphoserine(CDC2)HMM predict
967Phosphoserine(IKK)HMM predict
969O-linkedHMM predict
969PhosphoserineHMM predict
970Phosphoserine(IKK)HMM predict
971O-linkedHMM predict
971Phosphoserine(CDC2)HMM predict
971Phosphoserine(CDK)HMM predict
992O-linkedHMM predict
993O-linkedHMM predict
993O-linkedHMM predict
993Phosphothreonine(CDK)HMM predict
996Phosphothreonine(CDC2)HMM predict
996Phosphothreonine(MAPK)HMM predict
996Phosphothreonine(CDK)HMM predict
1022MethylarginineHMM predict
1026O-linkedHMM predict
1026Phosphoserine(ATM)HMM predict
1031O-linkedHMM predict
1031Phosphoserine(CDC2)HMM predict
1040O-linkedHMM predict
1058O-linkedHMM predict
1059O-linkedHMM predict
1059Phosphoserine(CDC2)HMM predict
1071Phosphothreonine(PKA)HMM predict
1071Phosphothreonine(CDK)HMM predict
1075Phosphothreonine(MAPK)HMM predict
1075Phosphothreonine(CDK)HMM predict
1089Phosphoserine(ATM)HMM predict
1100Phosphothreonine(PKC)HMM predict
1105Phosphoserine(CAMK2)HMM predict
1105Phosphoserine(PKB)HMM predict
1108O-linkedHMM predict
1108Phosphoserine(IKK)HMM predict
1109Phosphoserine(ATM)HMM predict
1132O-linkedHMM predict
1142Phosphotyrosine(Abl)HMM predict
1157O-linkedHMM predict
1157Phosphoserine(PKA)HMM predict
1158O-linkedHMM predict
1160O-linkedHMM predict
1160Phosphoserine(IKK)HMM predict
1174O-linkedHMM predict
1175O-linkedHMM predict
1181O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005477
  • Location:chr15 71400987-71448229
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 71467636 71468318 682 19748
CTCF G2GSE9613 71448819 71449052 233 706
CTCF G2GSE9613 71454945 71455268 323 6877
H3K27me3 colorectalcancer 71449389 71450795 1406 1863
H3K27me3 colorectalcancer 71451099 71452276 1177 3458
P300 T30-glioblastomaGSE21026 71467739 71468251 512 19766
Rb GrowingGSE19898 71467206 71467489 283 19118
Sox2 hESGSE18292 71466849 71467260 411 18825
TFAP2C MCF7GSE21234 71455139 71455745 606 7213
hScc1 BcellGSE12603 71448877 71449361 484 890
hScc1 BcellGSE12603 71459114 71459352 238 11004
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 71397164 71397517 353 3647
CTCF G2GSE9613 71398092 71398375 283 2754
hScc1 BcellGSE12603 71398092 71398322 230 2781
hScc1 BcellGSE12603 71398727 71398894 167 2177
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF JurkatGSE12889 71404785 71404933 148 0
CTCF G2GSE9613 71404761 71404907 146 0
CTCF G2GSE9613 71411139 71411332 193 0
CTCF G2GSE9613 71419607 71419900 293 0
CTCF G2GSE9613 71435919 71436058 139 0
CTCF G2GSE9613 71441395 71442374 979 0
CTCF G2GSE9613 71447121 71447605 484 0
H3K27me3 colorectalcancer 71445798 71446121 323 0
NFkBII GM12892GSE19485 71404437 71405534 1097 0
NRSF JurkatGSE13047 71425335 71428048 2713 0
NRSF mAbJurkat 71420021 71420286 265 0
NRSF mAbJurkat 71421471 71421831 360 0
NRSF mAbJurkat 71422645 71433105 10460 0
NRSF-mono JurkatQuESTdata 71425831 71427371 1540 0
NRSF-poly JurkatQuESTdata 71425436 71427255 1819 0
Nanog hESGSE18292 71410278 71410419 141 0
Oct4 hESGSE17917 71426094 71426449 355 0
hScc1 BcellGSE12603 71403183 71403595 412 0
hScc1 BcellGSE12603 71404220 71404907 687 0
hScc1 BcellGSE12603 71407076 71407428 352 0
hScc1 BcellGSE12603 71409843 71410545 702 0
hScc1 BcellGSE12603 71436703 71437083 380 0
hScc1 BcellGSE12603 71447085 71448121 1036 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 17516552
hsa-miR-1 hsa-mir-1-1 20 17516552
hsa-miR-1 hsa-mir-1-2 18 18458081
hsa-miR-1 hsa-mir-1-1 20 18458081
hsa-miR-133a hsa-mir-133a-1 18 17516552
hsa-miR-133a hsa-mir-133a-2 20 17516552
hsa-miR-133a hsa-mir-133a-1 18 18458081
hsa-miR-133a hsa-mir-133a-2 20 18458081
hsa-miR-133b hsa-mir-133b 6 17516552
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
221 mRNA repression TRUE miR-1 HCN4 Luciferase assay - mutant MRE 18458081
453 mRNA repression FALSE miR-133 HCN4 Luciferase assay - mutant MRE 18458081
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000138622 "cardiac and skeletal muscles, cardiogenesis" cardiac hypertrophy down regulated n_a n_a
ENSG00000138622 "cardiac and skeletal muscles, cardiogenesis" cardiac hypertrophy down regulated n_a n_a
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
9042 EST chr15 71414669 71421781 7112 mRNA HCN4 chr15 71400987 71448230 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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