AutismKB 2.0

Annotation Detail for CHAF1A


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Basic Information Top
Gene Symbol:CHAF1A ( CAF-1,CAF1,CAF1B,CAF1P150,MGC71229,P150 )
Gene Full Name: chromatin assembly factor 1, subunit A (p150)
Band: 19p13.3
Quick LinksEntrez ID:10036; OMIM: 601246; Uniprot ID:CAF1A_HUMAN; ENSEMBL ID: ENSG00000167670; HGNC ID: 1910
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
65Phosphoserine.
141Phosphoserine.
199Phosphoserine.
203Phosphoserine.
206Phosphoserine.
224Phosphoserine.
246PxVxL motif.
255Phosphoserine.
259Phosphothreonine.
722Phosphothreonine.
772Phosphoserine.
775Phosphoserine.
865Phosphothreonine.
873Phosphoserine.
951Phosphoserine.
Location(AA) Modifications Resource
47Phosphoserine.Swiss-Prot 53.0
123Phosphoserine.Swiss-Prot 53.0
123PhosphoserinePhospho.ELM 6.0
188Phosphoserine.Swiss-Prot 53.0
188PhosphoserinePhospho.ELM 6.0
237Phosphoserine.Swiss-Prot 53.0
241Phosphothreonine.Swiss-Prot 53.0
754Phosphoserine.Swiss-Prot 53.0
933Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
36Phosphoserine(CK1)HMM predict
111Phosphoserine(IKK)HMM predict
123Phosphoserine(CDC2)HMM predict
136Phosphothreonine(CK2)HMM predict
241Phosphothreonine(CDC2)HMM predict
246N-linkedHMM predict
248Phosphothreonine(CDC2)HMM predict
248Phosphothreonine(MAPK)HMM predict
262Phosphoserine(CK1)HMM predict
270Phosphoserine(CK1)HMM predict
271Phosphoserine(CDC2)HMM predict
271Phosphoserine(IKK)HMM predict
273Phosphoserine(CK2)HMM predict
273Phosphoserine(CK1)HMM predict
274Phosphoserine(IKK)HMM predict
275O-linkedHMM predict
275O-linkedHMM predict
276Phosphoserine(CK1)HMM predict
277Phosphoserine(CDK)HMM predict
277Phosphoserine(IKK)HMM predict
277Phosphoserine(CDC2)HMM predict
289Phosphoserine(IKK)HMM predict
289O-linkedHMM predict
290O-linkedHMM predict
292O-linkedHMM predict
292Phosphoserine(CDC2)HMM predict
296O-linkedHMM predict
296O-linkedHMM predict
298Phosphothreonine(CDK)HMM predict
298Phosphothreonine(MAPK)HMM predict
304Phosphothreonine(PKA)HMM predict
436Phosphothreonine(CDC2)HMM predict
467Phosphothreonine(PKA)HMM predict
582Phosphoserine(CK1)HMM predict
598Phosphoserine(ATM)HMM predict
598Phosphoserine(CK2)HMM predict
624Phosphoserine(CK2)HMM predict
704Phosphothreonine(MAPK)HMM predict
730N-linkedHMM predict
750N-linkedHMM predict
754Phosphoserine(CDC2)HMM predict
754O-linkedHMM predict
754Phosphoserine(CDK)HMM predict
757Phosphothreonine(CDK)HMM predict
757Phosphothreonine(MAPK)HMM predict
759O-linkedHMM predict
761O-linkedHMM predict
762Phosphotyrosine(Jak)HMM predict
765Phosphothreonine(MAPK)HMM predict
765O-linkedHMM predict
790Phosphotyrosine(Syk)HMM predict
829O-linkedHMM predict
837O-linkedHMM predict
837Phosphoserine(ATM)HMM predict
837Phosphoserine(IKK)HMM predict
837Phosphoserine(CK1)HMM predict
840O-linkedHMM predict
844O-linkedHMM predict
844Phosphoserine(ATM)HMM predict
858Phosphoserine(IKK)HMM predict
886Phosphothreonine(CK2)HMM predict
929O-linkedHMM predict
933Phosphoserine(CDC2)HMM predict
933Phosphoserine(CDK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005483
  • Location:chr19 4353659-4394392
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 4352907 4353696 789 358
Rb shRbQuiescentGSE19898 4353524 4353707 183 44
TAF k562GSE8489 4352672 4353396 724 626
USF1 HepG2E 4352373 4353511 1138 718
p130 QuiescentGSE19898 4353075 4353744 669 250
p130 SenescentGSE19898 4353036 4353647 611 318
p130 shRbQuiescentGSE19898 4353164 4353800 636 178
p130 shRbSenescentGSE19898 4353153 4353791 638 188
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 4354017 4354518 501 0
Nanog hESGSE18292 4360138 4360424 286 0
Oct1 H2O2-HelaGSE14283 4377361 4377391 30 0
Rb GrowingGSE19898 4353904 4354128 224 0
Rb GrowingGSE19898 4354341 4354553 212 0
Rb QuiescentGSE19898 4353403 4353987 584 0
Rb SenescentGSE19898 4353403 4354240 837 0
Rb shRbQuiescentGSE19898 4354410 4354627 217 0
TFAP2C MCF7GSE21234 4391405 4391846 441 0
USF1 HepG2E 4354156 4354518 362 0
p130 shRbQuiescentGSE19898 4353958 4354447 489 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 19716330
hsa-let-7a hsa-let-7a-2 11 19716330
hsa-let-7a hsa-let-7a-3 22 19716330
hsa-let-7a* hsa-let-7a-1 9 19716330
hsa-let-7a* hsa-let-7a-3 22 19716330
hsa-let-7b hsa-let-7b 22 19716330
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 19716330
hsa-let-7b* hsa-let-7b 22 18668040
hsa-let-7c hsa-let-7c 21 19716330
hsa-let-7c* hsa-let-7c 21 19716330
hsa-let-7d hsa-let-7d 9 19716330
hsa-let-7d* hsa-let-7d 9 19716330
hsa-let-7e hsa-let-7e 19 19716330
hsa-let-7e* hsa-let-7e 19 19716330
hsa-let-7f hsa-let-7f-1 9 19716330
hsa-let-7f hsa-let-7f-2 X 19716330
hsa-let-7f-1* hsa-let-7f-1 9 19716330
hsa-let-7f-2* hsa-let-7f-2 X 19716330
hsa-let-7g hsa-let-7g 3 19716330
hsa-let-7g* hsa-let-7g 3 19716330
hsa-let-7i hsa-let-7i 12 19716330
hsa-let-7i* hsa-let-7i 12 19716330
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
947 Unknown pSILAC miR-155 CHAF1A down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000167670 n_a n_a n_a "epithelium, lymphocyte" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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