AutismKB 2.0

Annotation Detail for HUWE1


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Basic Information Top
Gene Symbol:HUWE1 ( ARF-BP1,HECTH9,HSPC272,Ib772,KIAA0312,LASU1,MULE,UREB1 )
Gene Full Name: HECT, UBA and WWE domain containing 1
Band: Xp11.22
Quick LinksEntrez ID:10075; OMIM: 300697; Uniprot ID:HUWE1_HUMAN; ENSEMBL ID: ENSG00000086758; HGNC ID: 30892
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
509N6-acetyllysine.
1084Phosphoserine.
1368Phosphoserine.
1370Phosphoserine.
1395Phosphoserine.
1840N6-acetyllysine.
1903Phosphoserine.
1907Phosphoserine.
2248N6-acetyllysine.
2362Phosphoserine.
2365Phosphoserine.
2366Phosphothreonine.
2377Phosphoserine.
2391Phosphoserine.
2526Phosphoserine.
2595Phosphoserine.
2619Phosphoserine.
2746Phosphothreonine.
2751Phosphothreonine.
2887Phosphoserine.
2888Phosphoserine.
2889Phosphothreonine.
2918Phosphoserine.
3116Phosphoserine.
3373Phosphoserine.
3377Phosphoserine.
3662Phosphoserine.
3752Phosphoserine.
3757Phosphoserine.
3759Phosphoserine.
3797Phosphoserine.
3808Phosphoserine.
3816Phosphoserine.
3822Phosphothreonine.
3919Phosphoserine.
3924Phosphothreonine.
3927Phosphothreonine.
4271Phosphotyrosine (By similarity).
Location(AA) Modifications Resource
1395Phosphoserine.Swiss-Prot 53.0
1395PhosphoserinePhospho.ELM 6.0
1907PhosphoserinePhospho.ELM 6.0
1907Phosphoserine.Swiss-Prot 53.0
2362Phosphoserine.Swiss-Prot 53.0
2362PhosphoserinePhospho.ELM 6.0
2887Phosphoserine.Swiss-Prot 53.0
2889PhosphothreoninePhospho.ELM 6.0
2918Phosphoserine.Swiss-Prot 53.0
3757Phosphoserine (By similarity).Swiss-Prot 53.0
3808PhosphoserinePhospho.ELM 6.0
3808Phosphoserine.Swiss-Prot 53.0
3816PhosphoserinePhospho.ELM 6.0
3816Phosphoserine.Swiss-Prot 53.0
3919PhosphoserinePhospho.ELM 6.0
3919Phosphoserine.Swiss-Prot 53.0
3924PhosphothreoninePhospho.ELM 6.0
3924Phosphothreonine.Swiss-Prot 53.0
3927Phosphothreonine.Swiss-Prot 53.0
3927PhosphothreoninePhospho.ELM 6.0
4271Phosphotyrosine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
98N-linkedHMM predict
113Phosphotyrosine(INSR)HMM predict
203Phosphotyrosine(Syk)HMM predict
217Phosphothreonine(PKA)HMM predict
218Phosphoserine(PKA)HMM predict
235Phosphoserine(CDC2)HMM predict
235Phosphoserine(ATM)HMM predict
483N-linkedHMM predict
549Phosphotyrosine(Syk)HMM predict
571Phosphoserine(IKK)HMM predict
574Phosphoserine(CK1)HMM predict
648Phosphoserine(PKA)HMM predict
648Phosphoserine(PKA)HMM predict
648Phosphoserine(PKG)HMM predict
648PhosphoserineHMM predict
648Phosphoserine(PKA)HMM predict
649Phosphoserine(PKA)HMM predict
649Phosphoserine(PKB)HMM predict
649Phosphoserine(PKA)HMM predict
657Phosphoserine(IKK)HMM predict
672Phosphothreonine(PKA)HMM predict
726Phosphoserine(CK1)HMM predict
726Phosphoserine(CK2)HMM predict
727Phosphoserine(CK1)HMM predict
727Phosphoserine(CK2)HMM predict
727Phosphoserine(CK2)HMM predict
742N-linkedHMM predict
747N-linkedHMM predict
752N-linkedHMM predict
783N-linkedHMM predict
784N-linkedHMM predict
853Phosphoserine(CK1)HMM predict
864Phosphoserine(CDC2)HMM predict
935Phosphoserine(CK1)HMM predict
990Phosphoserine(PKG)HMM predict
1024O-linkedHMM predict
1077Phosphoserine(CDC2)HMM predict
1089O-linkedHMM predict
1089O-linkedHMM predict
1090O-linkedHMM predict
1090Phosphothreonine(PKC)HMM predict
1091O-linkedHMM predict
1092O-linkedHMM predict
1095Phosphothreonine(MAPK)HMM predict
1100O-linkedHMM predict
1101O-linkedHMM predict
1120Phosphotyrosine(Abl)HMM predict
1121Phosphothreonine(MAPK)HMM predict
1123O-linkedHMM predict
1211N-linkedHMM predict
1221Phosphoserine(MAPK)HMM predict
1221Phosphoserine(IKK)HMM predict
1292Phosphoserine(PKG)HMM predict
1304Phosphothreonine(CK2)HMM predict
1341N-linkedHMM predict
1370Phosphoserine(CK1)HMM predict
1370Phosphoserine(CK2)HMM predict
1476Phosphotyrosine(INSR)HMM predict
1504O-linkedHMM predict
1631O-linkedHMM predict
1633Phosphoserine(IKK)HMM predict
1634N-linkedHMM predict
1635N-linkedHMM predict
1658Phosphotyrosine(Jak)HMM predict
1659Phosphothreonine(PKA)HMM predict
1659PhosphothreonineHMM predict
1720N-linkedHMM predict
1722Phosphothreonine(MAPK)HMM predict
1731Phosphothreonine(CK2)HMM predict
1736Phosphoserine(CK1)HMM predict
1736Phosphoserine(CK2)HMM predict
1736Phosphoserine(IKK)HMM predict
1786Phosphothreonine(PKA)HMM predict
1791Phosphotyrosine(Syk)HMM predict
1806N-linkedHMM predict
1848O-linkedHMM predict
1848O-linkedHMM predict
1848O-linkedHMM predict
1848Phosphoserine(IKK)HMM predict
1852O-linkedHMM predict
1853O-linkedHMM predict
1854O-linkedHMM predict
1855O-linkedHMM predict
1855O-linkedHMM predict
1859O-linkedHMM predict
1903O-linkedHMM predict
1933Phosphoserine(CDC2)HMM predict
1988Phosphotyrosine(EGFR)HMM predict
1988Phosphotyrosine(Syk)HMM predict
1999Phosphoserine(PKB)HMM predict
2023O-linkedHMM predict
2024O-linkedHMM predict
2024O-linkedHMM predict
2024Phosphoserine(IKK)HMM predict
2026O-linkedHMM predict
2026Phosphoserine(CK2)HMM predict
2026Phosphoserine(IKK)HMM predict
2029Phosphoserine(ATM)HMM predict
2034Phosphoserine(CK2)HMM predict
2035Phosphothreonine(CDC2)HMM predict
2035Phosphothreonine(MAPK)HMM predict
2035Phosphothreonine(CDK)HMM predict
2091N-linkedHMM predict
2094Phosphotyrosine(Jak)HMM predict
2195Phosphoserine(IKK)HMM predict
2199O-linkedHMM predict
2231Phosphoserine(IKK)HMM predict
2252Phosphothreonine(PKC)HMM predict
2266Phosphoserine(IKK)HMM predict
2271Phosphoserine(CK1)HMM predict
2273N-linkedHMM predict
2283Phosphoserine(ATM)HMM predict
2283Phosphoserine(IKK)HMM predict
2286Phosphoserine(CK1)HMM predict
2286Phosphoserine(IKK)HMM predict
2287Phosphoserine(CK1)HMM predict
2287Phosphoserine(IKK)HMM predict
2362Phosphoserine(IKK)HMM predict
2364N-linkedHMM predict
2372PhosphoserineHMM predict
2377Phosphoserine(ATM)HMM predict
2377PhosphoserineHMM predict
2389N-linkedHMM predict
2391Phosphoserine(IKK)HMM predict
2421Phosphoserine(CK1)HMM predict
2422Phosphoserine(CK1)HMM predict
2431Phosphoserine(CK1)HMM predict
2431Phosphoserine(ATM)HMM predict
2463Phosphoserine(CK2)HMM predict
2471Phosphotyrosine(Syk)HMM predict
2471SulfotyrosineHMM predict
2508O-linkedHMM predict
2508Phosphoserine(CDC2)HMM predict
2536O-linkedHMM predict
2595Phosphoserine(CK1)HMM predict
2636Phosphoserine(IKK)HMM predict
2640O-linkedHMM predict
2726Phosphoserine(IKK)HMM predict
2727N-linkedHMM predict
2729Phosphoserine(CK1)HMM predict
2733N-linkedHMM predict
2735Phosphoserine(ATM)HMM predict
2746O-linkedHMM predict
2746Phosphothreonine(PKC)HMM predict
2747O-linkedHMM predict
2747Phosphothreonine(MAPK)HMM predict
2747Phosphothreonine(CDK)HMM predict
2749O-linkedHMM predict
2750O-linkedHMM predict
2751O-linkedHMM predict
2751O-linkedHMM predict
2756O-linkedHMM predict
2768Phosphoserine(ATM)HMM predict
2773O-linkedHMM predict
2776Phosphothreonine(MAPK)HMM predict
2776Phosphothreonine(CDK)HMM predict
2789Phosphoserine(CDC2)HMM predict
2789Phosphoserine(MAPK)HMM predict
2815Phosphoserine(CK2)HMM predict
2826O-linkedHMM predict
2826Phosphoserine(ATM)HMM predict
2830O-linkedHMM predict
2835Phosphoserine(CDC2)HMM predict
2835Phosphoserine(CDK)HMM predict
2849Phosphoserine(CK2)HMM predict
2861Phosphoserine(IKK)HMM predict
2887Phosphoserine(PKG)HMM predict
2888O-linkedHMM predict
2907Phosphoserine(CK2)HMM predict
2918Phosphoserine(IKK)HMM predict
2923Phosphoserine(CK1)HMM predict
2926Phosphoserine(CK1)HMM predict
2931O-linkedHMM predict
2952Phosphoserine(CK1)HMM predict
2952Phosphoserine(CK2)HMM predict
2953Phosphoserine(CK1)HMM predict
3000O-linkedHMM predict
3002N-linkedHMM predict
3004O-linkedHMM predict
3049N-linkedHMM predict
3127Phosphoserine(CDC2)HMM predict
3201N-linkedHMM predict
3247Phosphothreonine(PKC)HMM predict
3258Phosphoserine(IKK)HMM predict
3261Phosphoserine(CK1)HMM predict
3312Phosphothreonine(PKA)HMM predict
3312Phosphothreonine(PKC)HMM predict
3376O-linkedHMM predict
3377Phosphoserine(CK1)HMM predict
3377Phosphoserine(ATM)HMM predict
3380Phosphoserine(CK1)HMM predict
3407Phosphoserine(PKG)HMM predict
3425O-linkedHMM predict
3425Phosphoserine(IKK)HMM predict
3429Phosphoserine(CDC2)HMM predict
3429Phosphoserine(IKK)HMM predict
3447Phosphoserine(PKG)HMM predict
3470O-linkedHMM predict
3478O-linkedHMM predict
3478Phosphoserine(IKK)HMM predict
3481O-linkedHMM predict
3481O-linkedHMM predict
3483O-linkedHMM predict
3484O-linkedHMM predict
3485O-linkedHMM predict
3487O-linkedHMM predict
3488O-linkedHMM predict
3488O-linkedHMM predict
3491O-linkedHMM predict
3491O-linkedHMM predict
3491O-linkedHMM predict
3491Phosphoserine(IKK)HMM predict
3492O-linkedHMM predict
3495O-linkedHMM predict
3499O-linkedHMM predict
3499O-linkedHMM predict
3501O-linkedHMM predict
3503O-linkedHMM predict
3509Phosphothreonine(MAPK)HMM predict
3509Phosphothreonine(CDK)HMM predict
3512O-linkedHMM predict
3513O-linkedHMM predict
3525O-linkedHMM predict
3531O-linkedHMM predict
3533O-linkedHMM predict
3535O-linkedHMM predict
3541O-linkedHMM predict
3543O-linkedHMM predict
3545O-linkedHMM predict
3545O-linkedHMM predict
3547Phosphoserine(CDC2)HMM predict
3549O-linkedHMM predict
3555Phosphoserine(CDC2)HMM predict
3560O-linkedHMM predict
3794Phosphoserine(CK1)HMM predict
3796Phosphoserine(CK2)HMM predict
3797Phosphoserine(CK1)HMM predict
3797Phosphoserine(ATM)HMM predict
3799Phosphoserine(IKK)HMM predict
3816Phosphoserine(MAPK)HMM predict
3824Phosphoserine(IKK)HMM predict
3830Phosphothreonine(CDC2)HMM predict
3852Phosphoserine(CK1)HMM predict
3919O-linkedHMM predict
3919Phosphoserine(CDC2)HMM predict
3919Phosphoserine(MAPK)HMM predict
3919PhosphoserineHMM predict
3924Phosphothreonine(MAPK)HMM predict
3927Phosphothreonine(MAPK)HMM predict
3940PhosphoserineHMM predict
3945O-linkedHMM predict
3946O-linkedHMM predict
3947O-linkedHMM predict
4000Phosphotyrosine(Jak)HMM predict
4031Phosphotyrosine(EGFR)HMM predict
4094N-linkedHMM predict
4100N-linkedHMM predict
4143Phosphotyrosine(INSR)HMM predict
4350Phosphotyrosine(EGFR)HMM predict
4350Phosphotyrosine(INSR)HMM predict
4370GlycineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_031407
  • Location:chrX 53576476-53697775
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 53698151 53698187 36 394
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog hESGSE18292 53572486 53572894 408 3787
Oct1 HelaGSE14283 53569567 53569594 27 6896
RNAII Tamoxifen-MCF7GSE14664 53576445 53576489 44 10
Rb GrowingGSE19898 53574424 53574660 236 1935
VDR GM10861-UnstimGSE22484 53573272 53575177 1905 2252
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 53577078 53577329 251 0
CTCF G2GSE9613 53606136 53606427 291 0
ER E2-MCF7GSE14664 53613408 53613458 50 0
ER E2-MCF7GSE14664 53643025 53643057 32 0
ER Fulvestrant-MCF7GSE14664 53613404 53613448 44 0
Oct1 HelaGSE14283 53583357 53583407 50 0
Oct1 HelaGSE14283 53586685 53586727 42 0
Oct1 HelaGSE14283 53613405 53613457 52 0
Oct1 HelaGSE14283 53674015 53674068 53 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-100 hsa-mir-100 11 19851984
hsa-miR-100* hsa-mir-100 11 19851984
hsa-miR-124 hsa-mir-124-1 8 19851984
hsa-miR-124* hsa-mir-124-1 8 19851984
hsa-miR-196a hsa-mir-196a-2 12 19851984
hsa-miR-196a* hsa-mir-196a-2 12 19851984
hsa-miR-219-1-3p hsa-mir-219-1 6 19851984
hsa-miR-219-5p hsa-mir-219-1 6 19851984
hsa-miR-26a hsa-mir-26a-1 3 19851984
hsa-miR-26a hsa-mir-26a-2 12 19851984
hsa-miR-26a-1* hsa-mir-26a-1 3 19851984
hsa-miR-30a hsa-mir-30a 6 19851984
hsa-miR-30a* hsa-mir-30a 6 19851984
hsa-miR-30c hsa-mir-30c-1 1 19851984
hsa-miR-30c-1* hsa-mir-30c-1 1 19851984
hsa-miR-373 hsa-mir-373 19 19851984
hsa-miR-373* hsa-mir-373 19 19851984
hsa-miR-423-3p hsa-mir-423 17 19851984
hsa-miR-423-5p hsa-mir-423 17 19851984
hsa-miR-492 hsa-mir-492 12 19851984
hsa-miR-604 hsa-mir-604 10 19851984
hsa-miR-608 hsa-mir-608 10 19851984
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018