AutismKB 2.0

Annotation Detail for TNK2


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Basic Information Top
Gene Symbol:TNK2 ( ACK,ACK1,FLJ44758,FLJ45547,p21cdc42Hs )
Gene Full Name: tyrosine kinase, non-receptor, 2
Band: 3q29
Quick LinksEntrez ID:10188; OMIM: 606994; Uniprot ID:ACK1_HUMAN; ENSEMBL ID: ENSG00000061938; HGNC ID: 19297
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
101Phosphothreonine.
149Phosphoserine.
284Phosphotyrosine; by SRC and
517Phosphothreonine.
518Phosphotyrosine.
724Phosphoserine.
728Phosphoserine.
785Phosphoserine.
827Phosphotyrosine.
859Phosphotyrosine.
860Phosphotyrosine.
881Phosphoserine.
925Phosphothreonine.
Location(AA) Modifications Resource
149Phosphoserine.Swiss-Prot 53.0
284Phosphotyrosine (TNK2)Phospho.ELM 6.0
518Phosphotyrosine.Swiss-Prot 53.0
518PhosphotyrosinePhospho.ELM 6.0
826Phosphotyrosine.Swiss-Prot 53.0
826PhosphotyrosinePhospho.ELM 6.0
857Phosphotyrosine.Swiss-Prot 53.0
857PhosphotyrosinePhospho.ELM 6.0
858Phosphotyrosine.Swiss-Prot 53.0
858PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
31N-linkedHMM predict
74Phosphoserine(PKA)HMM predict
94Phosphoserine(ATM)HMM predict
101O-linkedHMM predict
102O-linkedHMM predict
102Phosphoserine(PKG)HMM predict
102PhosphoserineHMM predict
102Phosphoserine(CDC2)HMM predict
166Phosphoserine(CK1)HMM predict
284Phosphotyrosine(Jak)HMM predict
284SulfotyrosineHMM predict
308Phosphoserine(CAMK2)HMM predict
335N-linkedHMM predict
361Phosphotyrosine(Syk)HMM predict
361Phosphotyrosine(SRC)HMM predict
455Phosphoserine(ATM)HMM predict
498Phosphoserine(CK1)HMM predict
502Phosphoserine(CK1)HMM predict
503Phosphothreonine(PKC)HMM predict
517Phosphothreonine(PKC)HMM predict
518Phosphotyrosine(INSR)HMM predict
603PhosphothreonineHMM predict
607Phosphoserine(CDC2)HMM predict
607PhosphoserineHMM predict
607Phosphoserine(CDK)HMM predict
635Phosphotyrosine(Syk)HMM predict
635Phosphotyrosine(SRC)HMM predict
651N-linkedHMM predict
664O-linkedHMM predict
670Phosphotyrosine(Abl)HMM predict
700O-linkedHMM predict
723Phosphoserine(IKK)HMM predict
723Phosphoserine(MAPK)HMM predict
723Phosphoserine(CDC2)HMM predict
723O-linkedHMM predict
723PhosphoserineHMM predict
723Phosphoserine(ATM)HMM predict
727Phosphoserine(ATM)HMM predict
727Phosphoserine(CDK)HMM predict
727Phosphoserine(CDC2)HMM predict
727O-linkedHMM predict
729Phosphoserine(ATM)HMM predict
729Phosphoserine(CDC2)HMM predict
729O-linkedHMM predict
749Phosphothreonine(PKC)HMM predict
749Phosphothreonine(PKA)HMM predict
756O-linkedHMM predict
766O-linkedHMM predict
773Phosphoserine(CDC2)HMM predict
784Phosphoserine(ATM)HMM predict
784Phosphoserine(CDC2)HMM predict
784Phosphoserine(CDK)HMM predict
784O-linkedHMM predict
784Phosphoserine(MAPK)HMM predict
788O-linkedHMM predict
790Phosphothreonine(MAPK)HMM predict
790Phosphothreonine(CDK)HMM predict
792O-linkedHMM predict
792Phosphoserine(CDC2)HMM predict
792Phosphoserine(CDK)HMM predict
799O-linkedHMM predict
800O-linkedHMM predict
800Phosphoserine(CDK)HMM predict
800Phosphoserine(CDC2)HMM predict
807Phosphoserine(PKG)HMM predict
807O-linkedHMM predict
809Phosphoserine(CDC2)HMM predict
809Phosphoserine(ATM)HMM predict
809Phosphoserine(CDK)HMM predict
813O-linkedHMM predict
819Phosphoserine(IKK)HMM predict
826Phosphotyrosine(Abl)HMM predict
826Phosphotyrosine(INSR)HMM predict
858Phosphotyrosine(Syk)HMM predict
879Phosphoserine(IKK)HMM predict
879Phosphoserine(CDC2)HMM predict
884Phosphothreonine(MAPK)HMM predict
884O-linkedHMM predict
896O-linkedHMM predict
896O-linkedHMM predict
906O-linkedHMM predict
906O-linkedHMM predict
924N-linkedHMM predict
925N-linkedHMM predict
927N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001010938
  • Location:chr3 197074632-197106828
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 197062164 197062451 287 12325
CTCF CD4GSE12889 197070548 197070947 399 3885
CTCF CD4SISSRdata 197062164 197062451 287 12325
CTCF CD4SISSRdata 197070548 197070947 399 3885
CTCF HelaGSE12889 197062068 197062595 527 12301
CTCF G2GSE9613 197058428 197059244 816 15797
CTCF G2GSE9613 197060680 197061265 585 13660
CTCF G2GSE9613 197063920 197064101 181 10622
CTCF G2GSE9613 197065093 197065386 293 9393
CTCF G2GSE9613 197070267 197071814 1547 3592
FOXA1 MCF7GSE15244 197063463 197064101 638 10851
FOXA1 MCF7GSE15244 197070910 197072316 1406 3020
Rb SenescentGSE19898 197074401 197074565 164 150
TFAP2C MCF7GSE21234 197070315 197071114 799 3918
hScc1 BcellGSE12603 197058428 197059130 702 15854
hScc1 BcellGSE12603 197063920 197064101 181 10622
hScc1 BcellGSE12603 197070304 197071573 1269 3694
hScc1 CdLSGSE12603 197065989 197066266 277 8505
hScc1 CdLSGSE12603 197070447 197071133 686 3843
hScc1 CdLSGSE12603 197074142 197074647 505 238
hScc1 G2GSE9613 197070410 197071573 1163 3641
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 197105863 197106501 638 0
CTCF CD4SISSRdata 197105863 197106501 638 0
CTCF G2GSE9613 197074142 197075305 1163 0
CTCF G2GSE9613 197075632 197077070 1438 0
CTCF G2GSE9613 197077998 197081293 3295 0
CTCF G2GSE9613 197081612 197082337 725 0
CTCF G2GSE9613 197083296 197088134 4838 0
CTCF G2GSE9613 197088527 197089790 1263 0
CTCF G2GSE9613 197091226 197093792 2566 0
CTCF G2GSE9613 197094291 197094810 519 0
CTCF G2GSE9613 197095149 197095323 174 0
CTCF G2GSE9613 197095950 197096966 1016 0
CTCF G2GSE9613 197097250 197098165 915 0
CTCF G2GSE9613 197099504 197100028 524 0
CTCF G2GSE9613 197100706 197101292 586 0
CTCF G2GSE9613 197102769 197103914 1145 0
CTCF G2GSE9613 197104464 197105664 1200 0
FOXA1 MCF7GSE15244 197105971 197106362 391 0
Fos K562GSE19551 197087856 197088398 542 0
Myc K562GSE19551 197087916 197088377 461 0
RARG MCF7GSE15244 197075632 197077007 1375 0
TFAP2C MCF7GSE21234 197074322 197075481 1159 0
TFAP2C MCF7GSE21234 197088055 197088472 417 0
hScc1 BcellGSE12603 197074361 197075083 722 0
hScc1 BcellGSE12603 197075768 197076473 705 0
hScc1 BcellGSE12603 197078377 197079193 816 0
hScc1 BcellGSE12603 197084956 197086742 1786 0
hScc1 BcellGSE12603 197091549 197092300 751 0
hScc1 BcellGSE12603 197102769 197103115 346 0
hScc1 BcellGSE12603 197105502 197105664 162 0
hScc1 BcellGSE12603 197105971 197107469 1498 0
hScc1 CdLSGSE12603 197105971 197107346 1375 0
hScc1 G2GSE9613 197086778 197087332 554 0
hScc1 G2GSE9613 197100954 197101292 338 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-181c hsa-mir-181c 19 19482995
hsa-miR-181c* hsa-mir-181c 19 19482995
hsa-miR-7 hsa-mir-7-1 9 21156648
hsa-miR-7 hsa-mir-7-2 15 21156648
hsa-miR-7 hsa-mir-7-3 19 21156648
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
19220 mRNA chr3 197123256 197126438 294 mRNA TNK2 chr3 197078545 197124190Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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