AutismKB 2.0

Annotation Detail for ADAM10


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ADAM10 ( AD10,CD156c,HsT18717,MADM,kuz )
Gene Full Name: ADAM metallopeptidase domain 10
Band: 15q21.3
Quick LinksEntrez ID:102; OMIM: 602192; Uniprot ID:ADA10_HUMAN; ENSEMBL ID: ENSG00000137845; HGNC ID: 188
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
178Cysteine switch (By similarity).
267N-linked (GlcNAc...) (Potential).
278N-linked (GlcNAc...).
439N-linked (GlcNAc...) (Potential).
551N-linked (GlcNAc...) (Potential).
715SH3-binding (Potential).
728SH3-binding (Potential).
Location(AA) Modifications Resource
267N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
278N-linked (GlcNAc...).Swiss-Prot 53.0
439N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
551N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
54Phosphoserine(PKG)HMM predict
79Phosphothreonine(PKA)HMM predict
108SulfotyrosineHMM predict
108Phosphotyrosine(INSR)HMM predict
136Phosphotyrosine(INSR)HMM predict
163SulfotyrosineHMM predict
214Phosphothreonine(PKA)HMM predict
215Phosphothreonine(CK2)HMM predict
215Phosphothreonine(PKC)HMM predict
215Phosphothreonine(PKA)HMM predict
238Phosphothreonine(PKC)HMM predict
278N-linkedHMM predict
391Phosphoserine(CDK)HMM predict
400Phosphothreonine(MAPK)HMM predict
551N-linkedHMM predict
556N-linkedHMM predict
559Phosphothreonine(PKA)HMM predict
630Phosphoserine(IKK)HMM predict
667Phosphotyrosine(INSR)HMM predict
667Phosphotyrosine(Syk)HMM predict
703Phosphothreonine(CDK)HMM predict
719Phosphothreonine(CDK)HMM predict
737ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001110
  • Location:chr15 56675801-56829468
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 56831773 56831815 42 2326
H3ac HepG2E 56829643 56830111 468 409
Oct1 HelaGSE14283 56831765 56831811 46 2320
USF2 HepG2E 56828853 56830111 1258 14
hScc1 CdLSGSE12603 56837869 56838133 264 8533
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 56672478 56672741 263 3192
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 56828449 56828767 318 0
FOXA1 MCF7GSE15244 56683876 56684194 318 0
FOXA1 eGFPGSE10845 56683876 56684194 318 0
H3K4me2 HCT116GSE10453 56827787 56828355 568 0
H3K4me3 colorectalcancer 56827787 56828491 704 0
H3ac HepG2E 56827679 56828449 770 0
Nanog hESGSE18292 56746337 56747044 707 0
Oct1 H2O2-HelaGSE14283 56707051 56707081 30 0
Oct1 H2O2-HelaGSE14283 56722234 56722267 33 0
Oct1 H2O2-HelaGSE14283 56740443 56740471 28 0
Oct1 HelaGSE14283 56707050 56707081 31 0
Oct1 HelaGSE14283 56715156 56715198 42 0
Oct1 HelaGSE14283 56722241 56722271 30 0
PHF8 HeLaGSE20725 56828215 56829718 1503 0
RARA MCF7GSE15244 56683876 56684194 318 0
RNAII Tamoxifen-MCF7GSE14664 56811936 56811976 40 0
Sox2 hESGSE18292 56701022 56701196 174 0
TAF HelaGSE8489 56827344 56828413 1069 0
TFAP2C MCF7GSE21234 56691528 56692090 562 0
USF1 HepG2E 56828811 56830111 1300 0
hScc1 BcellGSE12603 56827968 56829318 1350 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-122 hsa-mir-122 18 19726678
hsa-miR-122 hsa-mir-122 18 19726678
hsa-miR-122* hsa-mir-122 18 19726678
hsa-miR-122* hsa-mir-122 18 19726678
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved