Annotation Detail for CDK6

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Basic Information Top

Gene Symbol:	CDK6 ( MGC59692,PLSTIRE )
Gene Full Name:	cyclin-dependent kinase 6
Band:	7q21.2
Quick Links	Entrez ID:1021; OMIM: 603368; Uniprot ID:CDK6_HUMAN; ENSEMBL ID: ENSG00000105810; HGNC ID: 1777
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:14 results
Experimental PTM Sites from dbPTM:4 results
Predicted PTM Sites by profile HMM from dbPTM:6 results

Location(AA)	Modification
13	Phosphotyrosine.
24	Phosphotyrosine.
43	N6-acetyllysine.
49	Phosphothreonine.
57	Phosphoserine.
70	Phosphothreonine.
86	Phosphoserine.
154	Phosphothreonine.
155	Phosphoserine.
223	Phosphoserine.
264	N6-acetyllysine.
290	Phosphoserine.
317	Phosphoserine.
325	Phosphothreonine.

Location(AA)	Modifications	Resource
13	Phosphotyrosine.	Swiss-Prot 53.0
13	Phosphotyrosine	Phospho.ELM 6.0
24	Phosphotyrosine.	Swiss-Prot 53.0
24	Phosphotyrosine	Phospho.ELM 6.0

Location(AA)	Modification	Resource
13	Phosphotyrosine(Syk)	HMM predict
24	Phosphotyrosine(EGFR)	HMM predict
49	Phosphothreonine(PKC)	HMM predict
309	Asparagine	HMM predict
317	Phosphoserine(ATM)	HMM predict
319	N-linked	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001259
Location:chr7 92072172-92301147
strand:-

Upstream the gene:13 results
Downstream the gene:0 results
Inside the gene:55 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	92302039	92303064	1025	1404
CTCF	G2	GSE9613	92303693	92304128	435	2763
H3ac	HepG2	E	92301301	92302073	772	540
H3ac	HepG2	E	92303235	92303620	385	2280
H3ac	HepG2	E	92304377	92305027	650	3555
Oct1	H2O2-Hela	GSE14283	92309411	92309441	30	8279
PHF8	HeLa	GSE20725	92303228	92304317	1089	2625
Pol2	GM12878	GSE19551	92303638	92304193	555	2768
Rb	Growing	GSE19898	92301093	92301307	214	53
TAF	k562	GSE8489	92304262	92305210	948	3589
hScc1	Bcell	GSE12603	92302012	92303103	1091	1410
hScc1	G2	GSE9613	92302039	92303498	1459	1621
hScc1	G2	GSE9613	92304128	92304738	610	3286

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CBP	Jurkat	GSE17954	92103865	92114097	10232
CBP	Jurkat	GSE17954	92220519	92223773	3254
CTCF	CD4	GSE12889	92088192	92088553	361
CTCF	CD4	GSE12889	92300265	92300591	326
CTCF	CD4	SISSRdata	92088192	92088553	361
CTCF	CD4	SISSRdata	92300265	92300591	326
CTCF	G2	GSE9613	92088212	92088710	498
CTCF	G2	GSE9613	92162935	92163195	260
CTCF	G2	GSE9613	92299958	92301470	1512
ER	Fulvestrant-MCF7	GSE14664	92135050	92135083	33
FOXA1	MCF7	GSE15244	92100447	92100920	473
FOXA1	MCF7	GSE15244	92233710	92234242	532
FoxA1	MCF7	MACSdata	92100677	92100857	180
H3K4me2	HCT116	GSE10453	92299115	92300077	962
H3K4me3	colorectal	cancer	92299376	92300290	914
H3ac	HepG2	E	92162262	92162975	713
H3ac	HepG2	E	92297527	92300250	2723
Myc	K562	GSE19551	92100611	92100946	335
Myc	K562	GSE19551	92158828	92159051	223
Myc	K562	GSE19551	92255951	92256247	296
Myc	hES	GSE17917	92300316	92300794	478
NFkBII	GM12878	GSE19485	92098028	92103452	5424
NFkBII	GM12892	GSE19485	92101141	92103059	1918
NRSF	mAb	Jurkat	92222431	92222830	399
NRSF	mAb	Jurkat	92299195	92300077	882
Nanog	ES	GSE20650	92191162	92191773	611
Oct1	H2O2-Hela	GSE14283	92277846	92277892	46
Oct1	H2O2-Hela	GSE14283	92295941	92295981	40
Oct1	H2O2-Hela	GSE14283	92296667	92296693	26
Oct1	Hela	GSE14283	92089388	92089434	46
Oct1	Hela	GSE14283	92254589	92254619	30
Oct1	Hela	GSE14283	92264057	92264089	32
Oct1	Hela	GSE14283	92277844	92277891	47
Oct1	Hela	GSE14283	92295942	92295981	39
Oct4	hES	GSE21916	92191248	92191595	347
Oct4	hES	GSE21916	92230828	92231459	631
P300	T30-glioblastoma	GSE21026	92207273	92208757	1484
RARA	MCF7	GSE15244	92184814	92185107	293
RNAII	Tamoxifen-MCF7	GSE14664	92277844	92277891	47
RNAII	Tamoxifen-MCF7	GSE14664	92295928	92295975	47
Rb	Growing	GSE19898	92276994	92277201	207
TFAP2C	MCF7	GSE21234	92208007	92208341	334
USF2	HepG2	E	92162479	92163020	541
VDR	GM10855-stim	GSE22484	92279232	92286627	7395
hScc1	Bcell	GSE12603	92088176	92088710	534
hScc1	Bcell	GSE12603	92236081	92236459	378
hScc1	Bcell	GSE12603	92299376	92301470	2094
hScc1	CdLS	GSE12603	92088176	92088742	566
hScc1	CdLS	GSE12603	92158692	92159210	518
hScc1	CdLS	GSE12603	92277007	92277583	576
hScc1	CdLS	GSE12603	92299339	92301624	2285
hScc1	G2	GSE9613	92088176	92088778	602
hScc1	G2	GSE9613	92298865	92301585	2720
p130	Quiescent	GSE19898	92265087	92265220	133
p130	Quiescent	GSE19898	92277017	92277238	221

Validated miRNA targets

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miR Walk:197 results
Tarbase V5.0:3 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	20876843
hsa-let-7a	hsa-let-7a-2	11	20876843
hsa-let-7a	hsa-let-7a-3	22	20876843
hsa-let-7a	hsa-let-7a-1	9	19688090
hsa-let-7a	hsa-let-7a-2	11	19688090
hsa-let-7a	hsa-let-7a-3	22	19688090
hsa-let-7a	hsa-let-7a-1	9	17699775
hsa-let-7a	hsa-let-7a-2	11	17699775
hsa-let-7a	hsa-let-7a-3	22	17699775
hsa-let-7a*	hsa-let-7a-1	9	20876843
hsa-let-7a*	hsa-let-7a-3	22	20876843
hsa-let-7a*	hsa-let-7a-1	9	19688090
hsa-let-7a*	hsa-let-7a-3	22	19688090
hsa-let-7a*	hsa-let-7a-1	9	17699775
hsa-let-7a*	hsa-let-7a-3	22	17699775
hsa-let-7b	hsa-let-7b	22	20876843
hsa-let-7b	hsa-let-7b	22	19688090
hsa-let-7b	hsa-let-7b	22	17699775
hsa-let-7b*	hsa-let-7b	22	20876843
hsa-let-7b*	hsa-let-7b	22	19688090
hsa-let-7b*	hsa-let-7b	22	17699775
hsa-let-7c	hsa-let-7c	21	20876843
hsa-let-7c	hsa-let-7c	21	19688090
hsa-let-7c	hsa-let-7c	21	17699775
hsa-let-7c*	hsa-let-7c	21	20876843
hsa-let-7c*	hsa-let-7c	21	19688090
hsa-let-7c*	hsa-let-7c	21	17699775
hsa-let-7d	hsa-let-7d	9	20876843
hsa-let-7d	hsa-let-7d	9	19688090
hsa-let-7d	hsa-let-7d	9	17699775
hsa-let-7d*	hsa-let-7d	9	20876843
hsa-let-7d*	hsa-let-7d	9	19688090
hsa-let-7d*	hsa-let-7d	9	17699775
hsa-let-7e	hsa-let-7e	19	20876843
hsa-let-7e	hsa-let-7e	19	19688090
hsa-let-7e	hsa-let-7e	19	17699775
hsa-let-7e*	hsa-let-7e	19	20876843
hsa-let-7e*	hsa-let-7e	19	19688090
hsa-let-7e*	hsa-let-7e	19	17699775
hsa-let-7f	hsa-let-7f-1	9	20876843
hsa-let-7f	hsa-let-7f-2	X	20876843
hsa-let-7f	hsa-let-7f-1	9	19688090
hsa-let-7f	hsa-let-7f-2	X	19688090
hsa-let-7f	hsa-let-7f-1	9	17699775
hsa-let-7f	hsa-let-7f-2	X	17699775
hsa-let-7f-1*	hsa-let-7f-1	9	20876843
hsa-let-7f-1*	hsa-let-7f-1	9	19688090
hsa-let-7f-1*	hsa-let-7f-1	9	17699775
hsa-let-7f-2*	hsa-let-7f-2	X	20876843
hsa-let-7f-2*	hsa-let-7f-2	X	19688090
hsa-let-7f-2*	hsa-let-7f-2	X	17699775
hsa-let-7g	hsa-let-7g	3	20876843
hsa-let-7g	hsa-let-7g	3	19688090
hsa-let-7g	hsa-let-7g	3	17699775
hsa-let-7g*	hsa-let-7g	3	20876843
hsa-let-7g*	hsa-let-7g	3	19688090
hsa-let-7g*	hsa-let-7g	3	17699775
hsa-let-7i	hsa-let-7i	12	20876843
hsa-let-7i	hsa-let-7i	12	19688090
hsa-let-7i	hsa-let-7i	12	17699775
hsa-let-7i*	hsa-let-7i	12	20876843
hsa-let-7i*	hsa-let-7i	12	19688090
hsa-let-7i*	hsa-let-7i	12	17699775
hsa-miR-1	hsa-mir-1-2	18	15685193
hsa-miR-1	hsa-mir-1-1	20	15685193
hsa-miR-103	hsa-mir-103-2	20	19407485
hsa-miR-103	hsa-mir-103-1	5	19407485
hsa-miR-107	hsa-mir-107	10	20833636
hsa-miR-107	hsa-mir-107	10	19688090
hsa-miR-107	hsa-mir-107	10	19407485
hsa-miR-124	hsa-mir-124-1	8	19843643
hsa-miR-124	hsa-mir-124-2	8	19843643
hsa-miR-124	hsa-mir-124-3	20	19843643
hsa-miR-124	hsa-mir-124-1	8	18607543
hsa-miR-124	hsa-mir-124-2	8	18607543
hsa-miR-124	hsa-mir-124-3	20	18607543
hsa-miR-124	hsa-mir-124-1	8	18577219
hsa-miR-124	hsa-mir-124-2	8	18577219
hsa-miR-124	hsa-mir-124-3	20	18577219
hsa-miR-124	hsa-mir-124-1	8	15685193
hsa-miR-124	hsa-mir-124-2	8	15685193
hsa-miR-124	hsa-mir-124-3	20	15685193
hsa-miR-124*	hsa-mir-124-1	8	19843643
hsa-miR-124*	hsa-mir-124-2	8	19843643
hsa-miR-124*	hsa-mir-124-3	20	19843643
hsa-miR-124*	hsa-mir-124-1	8	18607543
hsa-miR-124*	hsa-mir-124-2	8	18607543
hsa-miR-124*	hsa-mir-124-3	20	18607543
hsa-miR-125b	hsa-mir-125b-1	11	19414119
hsa-miR-125b	hsa-mir-125b-2	21	19414119
hsa-miR-127-3p	hsa-mir-127	14	17581274
hsa-miR-127-5p	hsa-mir-127	14	17581274
hsa-miR-137	hsa-mir-137	1	21051724
hsa-miR-137	hsa-mir-137	1	18577219
hsa-miR-137	hsa-mir-137	1	18381414
hsa-miR-148a	hsa-mir-148a	7	18768788
hsa-miR-148a*	hsa-mir-148a	7	18768788
hsa-miR-150	hsa-mir-150	19	20086245
hsa-miR-150*	hsa-mir-150	19	20086245
hsa-miR-155	hsa-mir-155	21	20086245
hsa-miR-155*	hsa-mir-155	21	20086245
hsa-miR-16	hsa-mir-16-1	13	18701644
hsa-miR-16	hsa-mir-16-2	3	18701644
hsa-miR-185	hsa-mir-185	22	19688090
hsa-miR-185*	hsa-mir-185	22	19688090
hsa-miR-193a-3p	hsa-mir-193a	17	18381414
hsa-miR-193a-5p	hsa-mir-193a	17	18381414
hsa-miR-195	hsa-mir-195	17	19441017
hsa-miR-195	hsa-mir-195	17	18701644
hsa-miR-195*	hsa-mir-195	17	19441017
hsa-miR-195*	hsa-mir-195	17	18701644
hsa-miR-203	hsa-mir-203	14	19843643
hsa-miR-203	hsa-mir-203	14	18381414
hsa-miR-21	hsa-mir-21	17	17991735
hsa-miR-21*	hsa-mir-21	17	17991735
hsa-miR-26a	hsa-mir-26a-1	3	21199804
hsa-miR-26a	hsa-mir-26a-2	12	21199804
hsa-miR-26a-1*	hsa-mir-26a-1	3	21199804
hsa-miR-26a-2*	hsa-mir-26a-2	12	21199804
hsa-miR-26b	hsa-mir-26b	2	21199804
hsa-miR-26b*	hsa-mir-26b	2	21199804
hsa-miR-29a	hsa-mir-29a	7	20086245
hsa-miR-29a	hsa-mir-29a	7	19850741
hsa-miR-29a	hsa-mir-29a	7	19407485
hsa-miR-29a*	hsa-mir-29a	7	20086245
hsa-miR-29a*	hsa-mir-29a	7	19850741
hsa-miR-29a*	hsa-mir-29a	7	19407485
hsa-miR-29b	hsa-mir-29b-1	7	20086245
hsa-miR-29b	hsa-mir-29b-2	1	20086245
hsa-miR-29b	hsa-mir-29b-1	7	19850741
hsa-miR-29b	hsa-mir-29b-2	1	19850741
hsa-miR-29b	hsa-mir-29b-1	7	19407485
hsa-miR-29b	hsa-mir-29b-2	1	19407485
hsa-miR-29b-1*	hsa-mir-29b-1	7	20086245
hsa-miR-29b-1*	hsa-mir-29b-1	7	19850741
hsa-miR-29b-2*	hsa-mir-29b-2	1	20086245
hsa-miR-29b-2*	hsa-mir-29b-2	1	19850741
hsa-miR-29c	hsa-mir-29c	1	20086245
hsa-miR-29c	hsa-mir-29c	1	19850741
hsa-miR-29c*	hsa-mir-29c	1	20086245
hsa-miR-29c*	hsa-mir-29c	1	19850741
hsa-miR-302a	hsa-mir-302a	4	21062975
hsa-miR-302a*	hsa-mir-302a	4	21062975
hsa-miR-302b	hsa-mir-302b	4	21062975
hsa-miR-302b*	hsa-mir-302b	4	21062975
hsa-miR-302c	hsa-mir-302c	4	21062975
hsa-miR-302c*	hsa-mir-302c	4	21062975
hsa-miR-302d	hsa-mir-302d	4	21062975
hsa-miR-302d*	hsa-mir-302d	4	21062975
hsa-miR-302f	hsa-mir-302f	0	21062975
hsa-miR-30a*	hsa-mir-30a	6	16239240
hsa-miR-34a	hsa-mir-34a	1	21321636
hsa-miR-34a	hsa-mir-34a	1	21051724
hsa-miR-34a	hsa-mir-34a	1	19960022
hsa-miR-34a	hsa-mir-34a	1	19773441
hsa-miR-34a	hsa-mir-34a	1	18719384
hsa-miR-34a	hsa-mir-34a	1	18406353
hsa-miR-34a	hsa-mir-34a	1	19461653
hsa-miR-34a*	hsa-mir-34a	1	21321636
hsa-miR-34a*	hsa-mir-34a	1	21051724
hsa-miR-34a*	hsa-mir-34a	1	19960022
hsa-miR-34a*	hsa-mir-34a	1	19773441
hsa-miR-34a*	hsa-mir-34a	1	18719384
hsa-miR-34a*	hsa-mir-34a	1	18406353
hsa-miR-34a*	hsa-mir-34a	1	19461653
hsa-miR-34b	hsa-mir-34b	11	21321636
hsa-miR-34b	hsa-mir-34b	11	19960022
hsa-miR-34b	hsa-mir-34b	11	18768788
hsa-miR-34b	hsa-mir-34b	11	18381414
hsa-miR-34b	hsa-mir-34b	11	19461653
hsa-miR-34b*	hsa-mir-34b	11	21321636
hsa-miR-34b*	hsa-mir-34b	11	19960022
hsa-miR-34b*	hsa-mir-34b	11	18768788
hsa-miR-34b*	hsa-mir-34b	11	18381414
hsa-miR-34b*	hsa-mir-34b	11	19461653
hsa-miR-34c-3p	hsa-mir-34c	11	21321636
hsa-miR-34c-3p	hsa-mir-34c	11	19960022
hsa-miR-34c-3p	hsa-mir-34c	11	18768788
hsa-miR-34c-3p	hsa-mir-34c	11	19461653
hsa-miR-34c-5p	hsa-mir-34c	11	21321636
hsa-miR-34c-5p	hsa-mir-34c	11	19960022
hsa-miR-34c-5p	hsa-mir-34c	11	18768788
hsa-miR-34c-5p	hsa-mir-34c	11	19461653
hsa-miR-373	hsa-mir-373	19	15685193
hsa-miR-373*	hsa-mir-373	19	15685193
hsa-miR-375	hsa-mir-375	2	19843643
hsa-miR-424	hsa-mir-424	X	18701644
hsa-miR-424*	hsa-mir-424	X	18701644
hsa-miR-449a	hsa-mir-449a	5	21321636
hsa-miR-449a	hsa-mir-449a	5	19960022
hsa-miR-449a	hsa-mir-449a	5	19833767
hsa-miR-449b	hsa-mir-449b	5	21321636
hsa-miR-449b	hsa-mir-449b	5	19960022
hsa-miR-494	hsa-mir-494	14	19925859
hsa-miR-9	hsa-mir-9-1	1	18768788
hsa-miR-9	hsa-mir-9-2	5	18768788
hsa-miR-9	hsa-mir-9-3	15	18768788

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
330	Unknown	MicroArray	miR-124	CDK6	n_a	15685193
608	mRNA repression	TRUE	miR-30a-3p	CDK6	n_a	16239240
615	mRNA cleavage	TRUE	miR-34a	CDK6	Luciferase assay	18406353
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000105810		G1-to-S transition	n_a	n_a	"epithelium, lymphoblast, leukocyte, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000105810		n_a	n_a	n_a	"epithelium, lymphoblast, leukocyte, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000105810		G1-to-S transition	tumor cell proliferation	up regulated	"epithelium, lymphoblast, leukocyte, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

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Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for CDK6

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics