AutismKB 2.0

Annotation Detail for TOPORS


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Basic Information Top
Gene Symbol:TOPORS ( LUN,P53BP3,RP31,TP53BPL )
Gene Full Name: topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Band: 9p21.1
Quick LinksEntrez ID:10210; OMIM: 609507; Uniprot ID:TOPRS_HUMAN; ENSEMBL ID: ENSG00000197579; HGNC ID: 21653
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
98Phosphoserine.
194Phosphoserine.
499Phosphoserine.
585Phosphoserine.
718Phosphoserine; by PLK1.
864Phosphoserine.
866Phosphoserine.
902Phosphoserine.
912Phosphoserine.
914Phosphoserine.
Location(AA) Modifications Resource
98Phosphoserine.Swiss-Prot 53.0
98PhosphoserinePhospho.ELM 6.0
560Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
902Phosphoserine.Swiss-Prot 53.0
902PhosphoserinePhospho.ELM 6.0
912Phosphoserine.Swiss-Prot 53.0
912PhosphoserinePhospho.ELM 6.0
914Phosphoserine.Swiss-Prot 53.0
914PhosphoserinePhospho.ELM 6.0
918PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
9Phosphoserine(CDC2)HMM predict
98Phosphoserine(IKK)HMM predict
119S-palmitoylHMM predict
168N-linkedHMM predict
173Phosphothreonine(CDC2)HMM predict
189N-linkedHMM predict
194Phosphoserine(CDC2)HMM predict
204Phosphothreonine(PKA)HMM predict
240Phosphothreonine(PKC)HMM predict
240Phosphothreonine(PKA)HMM predict
278Phosphotyrosine(INSR)HMM predict
325N-linkedHMM predict
346N-linkedHMM predict
361Phosphoserine(CDC2)HMM predict
374Phosphotyrosine(INSR)HMM predict
390Phosphoserine(CK1)HMM predict
420Phosphothreonine(CDC2)HMM predict
420Phosphothreonine(MAPK)HMM predict
426O-linkedHMM predict
427Phosphoserine(CK1)HMM predict
427O-linkedHMM predict
428Phosphoserine(ATM)HMM predict
440N-linkedHMM predict
445Phosphoserine(CK2)HMM predict
445Phosphoserine(CK1)HMM predict
469N-linkedHMM predict
498Phosphoserine(CK2)HMM predict
499Phosphoserine(CK1)HMM predict
507Phosphotyrosine(INSR)HMM predict
522Phosphotyrosine(Jak)HMM predict
523Phosphoserine(IKK)HMM predict
524Phosphoserine(ATM)HMM predict
524PhosphoserineHMM predict
530Phosphoserine(CK2)HMM predict
534Phosphoserine(IKK)HMM predict
534Phosphoserine(CDC2)HMM predict
534PhosphoserineHMM predict
537Phosphoserine(IKK)HMM predict
558Phosphoserine(PKG)HMM predict
566Phosphothreonine(PKA)HMM predict
567Phosphoserine(CAMK2)HMM predict
567Phosphoserine(CK1)HMM predict
567Phosphoserine(IKK)HMM predict
569Phosphoserine(CK1)HMM predict
575N-linkedHMM predict
600Phosphoserine(CK1)HMM predict
604Phosphoserine(ATM)HMM predict
604Phosphoserine(CK1)HMM predict
604Phosphoserine(IKK)HMM predict
635Phosphoserine(CK1)HMM predict
638MethylarginineHMM predict
648Phosphothreonine(PKA)HMM predict
648Phosphothreonine(PKC)HMM predict
652Phosphoserine(CAMK2)HMM predict
659Phosphothreonine(PKA)HMM predict
659Phosphothreonine(PKC)HMM predict
661Phosphoserine(IKK)HMM predict
664Phosphoserine(CK1)HMM predict
668Phosphoserine(CK1)HMM predict
674Phosphoserine(CK1)HMM predict
675Phosphoserine(PKC)HMM predict
675Phosphoserine(CK2)HMM predict
716Phosphotyrosine(Syk)HMM predict
716Phosphotyrosine(INSR)HMM predict
724Phosphothreonine(PKA)HMM predict
726Phosphoserine(PKG)HMM predict
731O-linkedHMM predict
734Phosphoserine(CK2)HMM predict
735Phosphoserine(PKB)HMM predict
735PhosphoserineHMM predict
736Phosphoserine(CDC2)HMM predict
755N-linkedHMM predict
761SulfotyrosineHMM predict
762SulfotyrosineHMM predict
771Phosphoserine(PKB)HMM predict
771Phosphoserine(IKK)HMM predict
771Phosphoserine(CK1)HMM predict
773Phosphoserine(CK1)HMM predict
775N-linkedHMM predict
798Phosphotyrosine(Jak)HMM predict
830Phosphoserine(CK1)HMM predict
836Phosphotyrosine(INSR)HMM predict
838N-linkedHMM predict
844Phosphoserine(CK1)HMM predict
848Phosphoserine(CK1)HMM predict
849Phosphoserine(CK2)HMM predict
849Phosphoserine(CK1)HMM predict
862Phosphothreonine(PKA)HMM predict
900N-linkedHMM predict
904Phosphoserine(CDC2)HMM predict
979N-linkedHMM predict
984N-linkedHMM predict
1028Phosphoserine(CDK)HMM predict
1028Phosphoserine(CDC2)HMM predict
1031ThreonineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005802
  • Location:chr9 32530542-32542600
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 32523328 32523624 296 7067
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 32540460 32542893 2433 0
H3K4me3 colorectalcancer 32541209 32542031 822 0
Myc hESGSE17917 32542232 32542527 295 0
P300 T30-glioblastomaGSE21026 32541783 32542911 1128 0
PHF8 293TGSE20725 32542010 32542909 899 0
PHF8 HeLaGSE20725 32542078 32543034 956 0
PHF8 Hs68plusFBSGSE20725 32541093 32543023 1930 0
PolII HeLaGSE12783 32540495 32543089 2594 0
Rb QuiescentGSE19898 32540838 32541207 369 0
Rb SenescentGSE19898 32540797 32541130 333 0
Rb shRbQuiescentGSE19898 32540800 32541123 323 0
TAF k562GSE8489 32541209 32543172 1963 0
USF1 HepG2E 32541209 32542888 1679 0
hScc1 BcellGSE12603 32540367 32541074 707 0
p130 QuiescentGSE19898 32540845 32541089 244 0
p130 SenescentGSE19898 32540854 32541277 423 0
p130 shRbQuiescentGSE19898 32540803 32541430 627 0
p130 shRbSenescentGSE19898 32540709 32541310 601 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
26317 mRNA chr9 32542343 32543005 170 mRNA TOPORS chr9 32530542 32542601Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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