AutismKB 2.0

Annotation Detail for SPRY2


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Basic Information Top
Gene Symbol:SPRY2 ( MGC23039,hSPRY2 )
Gene Full Name: sprouty homolog 2 (Drosophila)
Band: 13q31.1
Quick LinksEntrez ID:10253; OMIM: 602466; Uniprot ID:SPY2_HUMAN; ENSEMBL ID: ENSG00000136158; HGNC ID: 11270
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
141Phosphoserine.
142Phosphoserine.
Location(AA) Modifications Resource
55Phosphotyrosine (Src)Phospho.ELM 6.0
227PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
7Phosphoserine(IKK)HMM predict
9N-linkedHMM predict
11Phosphoserine(ATM)HMM predict
23MethylarginineHMM predict
25MethylarginineHMM predict
60O-linkedHMM predict
97Phosphoserine(IKK)HMM predict
97Phosphoserine(ATM)HMM predict
112Phosphoserine(IKK)HMM predict
112Phosphoserine(PKB)HMM predict
118O-linkedHMM predict
120Phosphoserine(CDC2)HMM predict
122O-linkedHMM predict
124O-linkedHMM predict
126O-linkedHMM predict
127O-linkedHMM predict
131Phosphoserine(CK1)HMM predict
176Phosphotyrosine(INSR)HMM predict
220S-palmitoylHMM predict
221S-palmitoylHMM predict
249S-palmitoylHMM predict
250S-palmitoylHMM predict
265S-palmitoylHMM predict
268S-palmitoylHMM predict
282S-palmitoylHMM predict
301S-farnesylHMM predict
304ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005842
  • Location:chr13 79808114-79813086
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 79813366 79813678 312 436
CTCF G2GSE9613 79814698 79815537 839 2031
ER MCF7GSE19013 79813249 79813933 684 505
H3K4me3 colorectalcancer 79814559 79814828 269 1607
H3ac HepG2E 79814401 79814947 546 1588
PolII HeLaGSE12783 79810827 79815482 4655 68
Sox2 hESGSE18292 79831671 79832229 558 18864
hScc1 BcellGSE12603 79814901 79815464 563 2096
hScc1 CdLSGSE12603 79814596 79815602 1006 2013
hScc1 CdLSGSE12603 79829187 79829375 188 16195
hScc1 G2GSE9613 79814669 79815537 868 2017
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
RNAII Tamoxifen-MCF7GSE14664 79806600 79806685 85 1472
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 79810965 79811607 642 0
CTCF G2GSE9613 79811943 79812584 641 0
ER E2-MCF7GSE14664 79809632 79809743 111 0
H3K4me3 colorectalcancer 79808604 79809578 974 0
H3K4me3 colorectalcancer 79810027 79812084 2057 0
H3K4me3 colorectalcancer 79812695 79813080 385 0
H3ac HepG2E 79808744 79809628 884 0
H3ac HepG2E 79809916 79812732 2816 0
TAF k562GSE8489 79810063 79812149 2086 0
hScc1 BcellGSE12603 79810929 79811441 512 0
hScc1 BcellGSE12603 79811841 79812262 421 0
hScc1 CdLSGSE12603 79810857 79811373 516 0
hScc1 G2GSE9613 79810791 79812824 2033 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 20545570
hsa-let-7a hsa-let-7a-2 11 20545570
hsa-let-7a hsa-let-7a-3 22 20545570
hsa-let-7a* hsa-let-7a-1 9 20545570
hsa-let-7a* hsa-let-7a-3 22 20545570
hsa-let-7b hsa-let-7b 22 20545570
hsa-let-7b* hsa-let-7b 22 20545570
hsa-let-7c hsa-let-7c 21 20545570
hsa-let-7c* hsa-let-7c 21 20545570
hsa-let-7d hsa-let-7d 9 20545570
hsa-let-7d* hsa-let-7d 9 20545570
hsa-let-7e hsa-let-7e 19 20545570
hsa-let-7e* hsa-let-7e 19 20545570
hsa-let-7f hsa-let-7f-1 9 20545570
hsa-let-7f hsa-let-7f-2 X 20545570
hsa-let-7f-1* hsa-let-7f-1 9 20545570
hsa-let-7f-2* hsa-let-7f-2 X 20545570
hsa-let-7g hsa-let-7g 3 20545570
hsa-let-7g* hsa-let-7g 3 20545570
hsa-let-7i hsa-let-7i 12 20545570
hsa-let-7i* hsa-let-7i 12 20545570
hsa-miR-15a hsa-mir-15a 13 20545570
hsa-miR-15a* hsa-mir-15a 13 20545570
hsa-miR-15b hsa-mir-15b 3 20545570
hsa-miR-15b* hsa-mir-15b 3 20545570
hsa-miR-16 hsa-mir-16-1 13 20545570
hsa-miR-16 hsa-mir-16-2 3 20545570
hsa-miR-21 hsa-mir-21 17 21099344
hsa-miR-21 hsa-mir-21 17 20693317
hsa-miR-21 hsa-mir-21 17 20560046
hsa-miR-21 hsa-mir-21 17 20545570
hsa-miR-21 hsa-mir-21 17 18508928
hsa-miR-21* hsa-mir-21 17 21099344
hsa-miR-21* hsa-mir-21 17 20693317
hsa-miR-21* hsa-mir-21 17 20560046
hsa-miR-21* hsa-mir-21 17 20545570
hsa-miR-21* hsa-mir-21 17 18508928
hsa-miR-27a hsa-mir-27a 19 20638779
hsa-miR-27a* hsa-mir-27a 19 20638779
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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