AutismKB 2.0

Annotation Detail for DENND4A


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Basic Information Top
Gene Symbol:DENND4A ( FLJ33949,IRLB,KIAA0476,MYCPBP )
Gene Full Name: DENN/MADD domain containing 4A
Band: 15q22.31
Quick LinksEntrez ID:10260; OMIM: 600382; Uniprot ID:MYCPP_HUMAN; ENSEMBL ID: ENSG00000174485; HGNC ID: 24321
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
728Phosphoserine.
731Phosphoserine.
933Bipartite nuclear localization signal
1099Phosphoserine.
1117Phosphoserine.
1225Phosphoserine.
1281Phosphoserine.
1511Phosphoserine.
1587Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
63Phosphotyrosine(INSR)HMM predict
79N-linkedHMM predict
125Phosphotyrosine(Abl)HMM predict
130N-linkedHMM predict
132O-linkedHMM predict
132O-linkedHMM predict
136Phosphoserine(CDC2)HMM predict
150N-linkedHMM predict
154N-linkedHMM predict
171Phosphoserine(ATM)HMM predict
184N-linkedHMM predict
185N-linkedHMM predict
193Phosphotyrosine(Jak)HMM predict
205O-linkedHMM predict
221Phosphotyrosine(Syk)HMM predict
221SulfotyrosineHMM predict
229Phosphoserine(ATM)HMM predict
283N-linkedHMM predict
304Phosphoserine(CK1)HMM predict
360Phosphoserine(CDC2)HMM predict
360Phosphoserine(CDK)HMM predict
379Phosphoserine(ATM)HMM predict
383Phosphoserine(IKK)HMM predict
384Phosphoserine(CDC2)HMM predict
384Phosphoserine(MAPK)HMM predict
478Phosphotyrosine(Syk)HMM predict
478SulfotyrosineHMM predict
591O-linkedHMM predict
593O-linkedHMM predict
616Phosphotyrosine(Syk)HMM predict
726O-linkedHMM predict
728Phosphoserine(CDC2)HMM predict
728Phosphoserine(ATM)HMM predict
728Phosphoserine(IKK)HMM predict
731Phosphoserine(CDC2)HMM predict
731Phosphoserine(MAPK)HMM predict
731Phosphoserine(IKK)HMM predict
754Phosphoserine(PKA)HMM predict
775S-palmitoylHMM predict
895Phosphoserine(ATM)HMM predict
908Phosphotyrosine(INSR)HMM predict
922Phosphoserine(CK2)HMM predict
935Phosphoserine(CK2)HMM predict
939Phosphoserine(CK1)HMM predict
939Phosphoserine(IKK)HMM predict
945Phosphoserine(CK1)HMM predict
960N-linkedHMM predict
979Phosphoserine(PKG)HMM predict
999N-linkedHMM predict
1003N-linkedHMM predict
1017N-linkedHMM predict
1020N-linkedHMM predict
1098Phosphoserine(CK2)HMM predict
1099Phosphoserine(CK1)HMM predict
1099Phosphoserine(CK2)HMM predict
1128Phosphoserine(CK1)HMM predict
1192Phosphoserine(CK1)HMM predict
1194Phosphoserine(CK1)HMM predict
1194Phosphoserine(IKK)HMM predict
1197Phosphothreonine(CDK)HMM predict
1214N-linkedHMM predict
1217Phosphoserine(CDC2)HMM predict
1217Phosphoserine(CDK)HMM predict
1225Phosphoserine(PKA)HMM predict
1225Phosphoserine(IKK)HMM predict
1251Phosphoserine(PKA)HMM predict
1256Phosphoserine(CDC2)HMM predict
1256Phosphoserine(MAPK)HMM predict
1282Phosphoserine(CDC2)HMM predict
1286Phosphoserine(CDC2)HMM predict
1295Phosphoserine(ATM)HMM predict
1303Phosphoserine(CDC2)HMM predict
1357Phosphoserine(CK1)HMM predict
1357Phosphoserine(IKK)HMM predict
1359Phosphoserine(CDC2)HMM predict
1366O-linkedHMM predict
1366Phosphoserine(IKK)HMM predict
1368Phosphoserine(CK1)HMM predict
1370Phosphoserine(CK1)HMM predict
1385O-linkedHMM predict
1385Phosphoserine(CK2)HMM predict
1386Phosphoserine(ATM)HMM predict
1389O-linkedHMM predict
1390O-linkedHMM predict
1390Phosphoserine(IKK)HMM predict
1404Phosphoserine(CK1)HMM predict
1410Phosphoserine(CK1)HMM predict
1410Phosphoserine(IKK)HMM predict
1429Phosphoserine(IKK)HMM predict
1431N-linkedHMM predict
1434N-linkedHMM predict
1436N-linkedHMM predict
1474Phosphoserine(IKK)HMM predict
1477N-linkedHMM predict
1509Phosphoserine(CDC2)HMM predict
1523Phosphoserine(CK1)HMM predict
1531Phosphoserine(CK1)HMM predict
1535O-linkedHMM predict
1535Phosphoserine(IKK)HMM predict
1570N-linkedHMM predict
1574Phosphothreonine(PKC)HMM predict
1587Phosphoserine(PKG)HMM predict
1609Phosphoserine(IKK)HMM predict
1629Phosphoserine(MAPK)HMM predict
1639Phosphoserine(CDC2)HMM predict
1639Phosphoserine(MAPK)HMM predict
1715Phosphotyrosine(INSR)HMM predict
1777Phosphotyrosine(SRC)HMM predict
1835Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005848
  • Location:chr15 63740595-63871639
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 63884632 63884799 167 13076
Gata2 K562GSE18868 63884257 63884946 689 12962
H3ac HepG2E 63871916 63872699 783 668
Myc K562GSE19551 63884378 63884990 612 13045
Rb GrowingGSE19898 63871483 63872083 600 144
Rb SenescentGSE19898 63871620 63872216 596 279
STAT1 HeLaGSE12782 63875032 63877499 2467 4626
STAT1 HeLaGSE12783 63875032 63877861 2829 4807
STAT1 IFNSISSRdata 63875535 63876715 1180 4486
TAF HelaGSE8489 63872185 63872678 493 792
TFAP2C MCF7GSE21234 63871707 63872158 451 293
hScc1 BcellGSE12603 63872011 63872241 230 487
p130 shRbQuiescentGSE19898 63871447 63872420 973 294
p130 shRbSenescentGSE19898 63871633 63872476 843 415
p63 keratinocytesGSE17611 63875605 63876405 800 4366
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 63871127 63871569 442 0
ER Fulvestrant-MCF7GSE14664 63759294 63759326 32 0
FoxA1 MCF7MACSdata 63846400 63846550 150 0
H3K4me3 colorectalcancer 63869960 63870903 943 0
H3ac HepG2E 63869166 63869654 488 0
H3ac HepG2E 63869997 63871127 1130 0
NFkBII GM10847GSE19485 63870258 63872861 2603 0
NFkBII GM12878GSE19485 63868634 63873033 4399 0
NFkBII GM18526GSE19485 63869988 63872922 2934 0
Oct1 H2O2-HelaGSE14283 63815199 63815231 32 0
Oct1 HelaGSE14283 63759292 63759327 35 0
Oct1 HelaGSE14283 63817524 63817562 38 0
Oct1 HelaGSE14283 63821283 63821330 47 0
P300 T0-glioblastomaGSE21026 63846204 63847056 852 0
P300 T30-glioblastomaGSE21026 63846247 63846944 697 0
P300 T30-glioblastomaGSE21026 63870402 63872749 2347 0
PHF8 293TGSE20725 63870728 63872547 1819 0
hScc1 BcellGSE12603 63871018 63871780 762 0
p63 keratinocytesGSE17611 63811829 63812665 836 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
8961 mRNA chr15 63824096 63825363 1267 mRNA MYCPBP chr15 63740595 63871640 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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