Annotation Detail for AKAP8

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Basic Information Top

Gene Symbol:	AKAP8 ( AKAP95,DKFZp586B1222 )
Gene Full Name:	A kinase (PRKA) anchor protein 8
Band:	19p13.12
Quick Links	Entrez ID:10270; OMIM: 604692; Uniprot ID:AKAP8_HUMAN; ENSEMBL ID: ENSG00000105127; HGNC ID: 378
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
112	Phosphoserine.
323	Phosphoserine.
328	Phosphoserine.
339	Phosphoserine.
377	Nuclear localization signal (Potential).
538	N6-acetyllysine.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	15350506	15352098	1592
ETS1	Jurkat	GSE17954	15350076	15352259	2183
H3K4me3	colorectal	cancer	15349981	15350506	525
H3ac	HepG2	E	15348318	15349244	926
H3ac	HepG2	E	15349582	15350917	1335
Myc	hES	GSE17917	15351243	15351564	321
PHF8	293T	GSE20725	15350316	15352147	1831
PHF8	HeLa	GSE20725	15350525	15352576	2051
PHF8	Hs68minusFBS	GSE20725	15350664	15352058	1394
RARA	MCF7	GSE15244	15349910	15350693	783
RUNX	Jurkat	GSE17954	15327650	15327705	55
TAF	k562	GSE8489	15349910	15350693	783
TFAP2C	MCF7	GSE21234	15346385	15346844	459
VDR	GM10855-Unstim	GSE22484	15349726	15352588	2862
VDR	GM10861-Unstim	GSE22484	15349684	15352848	3164
hScc1	Bcell	GSE12603	15339780	15340210	430
hScc1	Bcell	GSE12603	15345718	15346176	458
hScc1	Bcell	GSE12603	15350368	15352134	1766
p130	shRbSenescent	GSE19898	15350814	15351727	913

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
831	Unknown	pSILAC	let-7b	AKAP8	down 50-25%	18668040
910	Unknown	pSILAC	LNA_let-7b	AKAP8	up 25-50%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000105127		n_a	n_a	n_a	"squamous cell, lymphocyte, macrophage"	"benign tumour, malignant tumour, carcinoma, leukaemia, non-Hodgkin's, sarcoma"
ENSG00000105127		n_a	n_a	n_a	"squamous cell, lymphocyte, macrophage"	"benign tumour, malignant tumour, carcinoma, leukaemia, non-Hodgkin's, sarcoma"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018