AutismKB 2.0

Annotation Detail for UBE4B


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Basic Information Top
Gene Symbol:UBE4B ( E4,HDNB1,KIAA0684,UBOX3,UFD2,UFD2A )
Gene Full Name: ubiquitination factor E4B (UFD2 homolog, yeast)
Band: 1p36.22
Quick LinksEntrez ID:10277; OMIM: 613565; Uniprot ID:UBE4B_HUMAN; ENSEMBL ID: ENSG00000130939; HGNC ID: 12500
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
22Phosphothreonine.
26Phosphothreonine.
31Phosphoserine.
84Phosphoserine.
87Phosphoserine.
88Phosphoserine.
90Phosphoserine.
92Phosphoserine.
95Phosphothreonine.
101Phosphoserine.
105Phosphoserine.
803Phosphoserine.
1265Phosphoserine.
Location(AA) Modifications Resource
31Phosphoserine (By similarity).Swiss-Prot 53.0
88PhosphoserinePhospho.ELM 6.0
101Phosphoserine (By similarity).Swiss-Prot 53.0
105PhosphoserinePhospho.ELM 6.0
105Phosphoserine.Swiss-Prot 53.0
392PhosphoserinePhospho.ELM 6.0
803Phosphoserine.Swiss-Prot 53.0
803PhosphoserinePhospho.ELM 6.0
1265Phosphoserine.Swiss-Prot 53.0
1265PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
23Phosphoserine(IKK)HMM predict
23O-linkedHMM predict
23Phosphoserine(ATM)HMM predict
26O-linkedHMM predict
27O-linkedHMM predict
27Phosphothreonine(MAPK)HMM predict
31Phosphoserine(CDC2)HMM predict
45O-linkedHMM predict
50Phosphoserine(ATM)HMM predict
59N-linkedHMM predict
61Phosphothreonine(PKA)HMM predict
65Phosphoserine(CDC2)HMM predict
78Phosphoserine(CK1)HMM predict
84O-linkedHMM predict
86O-linkedHMM predict
86Phosphoserine(CK2)HMM predict
87O-linkedHMM predict
87Phosphoserine(CK1)HMM predict
88Phosphoserine(CDC2)HMM predict
88Phosphoserine(ATM)HMM predict
88Phosphoserine(IKK)HMM predict
92Phosphoserine(CK1)HMM predict
97Phosphoserine(ATM)HMM predict
97Phosphoserine(IKK)HMM predict
99Phosphoserine(IKK)HMM predict
103Phosphoserine(ATM)HMM predict
105Phosphoserine(IKK)HMM predict
118Phosphoserine(IKK)HMM predict
118Phosphoserine(CK1)HMM predict
143Phosphoserine(CK1)HMM predict
143Phosphoserine(ATM)HMM predict
143Phosphoserine(PKA)HMM predict
148Phosphoserine(CK2)HMM predict
226O-linkedHMM predict
229O-linkedHMM predict
254O-linkedHMM predict
262O-linkedHMM predict
270Phosphoserine(CK1)HMM predict
275O-linkedHMM predict
279O-linkedHMM predict
279O-linkedHMM predict
292O-linkedHMM predict
295Phosphoserine(CDC2)HMM predict
295Phosphoserine(CDK)HMM predict
297O-linkedHMM predict
301Phosphoserine(IKK)HMM predict
301Phosphoserine(PKG)HMM predict
307O-linkedHMM predict
308Phosphothreonine(MAPK)HMM predict
308Phosphothreonine(CDK)HMM predict
311Phosphoserine(CDK)HMM predict
311Phosphoserine(CDC2)HMM predict
314O-linkedHMM predict
317Phosphoserine(CK2)HMM predict
319O-linkedHMM predict
323Phosphoserine(ATM)HMM predict
323Phosphoserine(IKK)HMM predict
327Phosphoserine(CDC2)HMM predict
345O-linkedHMM predict
345Phosphoserine(IKK)HMM predict
348O-linkedHMM predict
348Phosphoserine(CK2)HMM predict
350Phosphoserine(ATM)HMM predict
350Phosphoserine(CDC2)HMM predict
352Phosphoserine(IKK)HMM predict
352O-linkedHMM predict
352Phosphoserine(ATM)HMM predict
359Phosphoserine(CDC2)HMM predict
373O-linkedHMM predict
373Phosphoserine(CDC2)HMM predict
374O-linkedHMM predict
375O-linkedHMM predict
383Phosphoserine(CDK)HMM predict
383O-linkedHMM predict
383Phosphoserine(MAPK)HMM predict
383Phosphoserine(CDC2)HMM predict
387Phosphothreonine(PKC)HMM predict
387O-linkedHMM predict
392PhosphoserineHMM predict
392Phosphoserine(CK1)HMM predict
454Phosphoserine(ATM)HMM predict
477Phosphothreonine(PKC)HMM predict
626Phosphoserine(CAMK2)HMM predict
719Phosphothreonine(PKA)HMM predict
728N-linkedHMM predict
787N-linkedHMM predict
796N-linkedHMM predict
803Phosphoserine(CDC2)HMM predict
987Phosphotyrosine(Syk)HMM predict
1032N-linkedHMM predict
1044Phosphoserine(CK1)HMM predict
1074Phosphoserine(PKG)HMM predict
1159Phosphotyrosine(Jak)HMM predict
1225SulfotyrosineHMM predict
1295ArginineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006048
  • Location:chr1 10015629-10163880
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 10015090 10015575 485 297
CTCF CD4SISSRdata 10015090 10015575 485 297
CTCF G2GSE9613 10015027 10015398 371 417
H3ac HepG2E 10014844 10014991 147 712
hScc1 BcellGSE12603 10014844 10015544 700 436
hScc1 CdLSGSE12603 10014844 10015423 579 496
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 10168478 10168694 216 4706
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 10056870 10057811 941 0
CTCF G2GSE9613 10088919 10089206 287 0
CTCF G2GSE9613 10162575 10162759 184 0
FOXA1 MCF7GSE15244 10038597 10039399 802 0
FoxA1 MCF7MACSdata 10129014 10129223 209 0
FoxA1 MCF7MACSdata 10151809 10152096 287 0
H3K4me3 colorectalcancer 10015902 10016799 897 0
H3ac HepG2E 10015823 10016868 1045 0
H3ac HepG2E 10017169 10017605 436 0
H3ac HepG2E 10119605 10119748 143 0
H3ac HepG2E 10153472 10153948 476 0
H3ac HepG2E 10154568 10154931 363 0
Myc K562GSE19551 10028499 10029105 606 0
Oct1 H2O2-HelaGSE14283 10063779 10063809 30 0
Oct1 H2O2-HelaGSE14283 10065360 10065386 26 0
Oct1 H2O2-HelaGSE14283 10093101 10093127 26 0
Oct1 H2O2-HelaGSE14283 10096779 10096812 33 0
Oct1 HelaGSE14283 10063780 10063810 30 0
Oct1 HelaGSE14283 10093101 10093132 31 0
Oct1 HelaGSE14283 10131730 10131770 40 0
P300 T30-glioblastomaGSE21026 10056932 10057800 868 0
P300 T30-glioblastomaGSE21026 10090238 10091845 1607 0
PHF8 HeLaGSE20725 10015214 10016197 983 0
RARA MCF7GSE15244 10067648 10068175 527 0
STAT1 IFNSISSRdata 10152697 10153418 721 0
TAF HelaGSE8489 10015902 10017605 1703 0
TAF k562GSE8489 10015938 10017605 1667 0
TFAP2C MCF7GSE21234 10129068 10129386 318 0
TFAP2C MCF7GSE21234 10153979 10154334 355 0
USF1 HepG2E 10015703 10017605 1902 0
USF2 HepG2E 10015456 10016799 1343 0
hScc1 BcellGSE12603 10088961 10089206 245 0
p63 keratinocytesGSE17611 10046260 10047276 1016 0
p63 keratinocytesGSE17611 10065458 10066249 791 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
179 mRNA UBE4B chr1 10027308 10175560 620 EST chr1 10174940 10175563Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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