AutismKB 2.0

Annotation Detail for ADAR


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Basic Information Top
Gene Symbol:ADAR ( ADAR1,DRADA,DSH,DSRAD,G1P1,IFI-4,IFI4,K88DSRBP,P136 )
Gene Full Name: adenosine deaminase, RNA-specific
Band: 1q21.3
Quick LinksEntrez ID:103; OMIM: 146920; Uniprot ID:DSRAD_HUMAN; ENSEMBL ID: ENSG00000160710; HGNC ID: 225
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
601Phosphothreonine.
603Phosphothreonine.
614Phosphoserine.
808Phosphothreonine.
818Phosphothreonine.
823Phosphoserine.
825Phosphoserine.
Location(AA) Modifications Resource
418Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
808Phosphothreonine.Swiss-Prot 53.0
818Phosphothreonine.Swiss-Prot 53.0
818PhosphothreoninePhospho.ELM 6.0
Location(AA) Modification Resource
20Phosphotyrosine(Syk)HMM predict
34Phosphoserine(IKK)HMM predict
35Phosphoserine(ATM)HMM predict
63Phosphoserine(PKA)HMM predict
63Phosphoserine(IKK)HMM predict
63O-linkedHMM predict
112Phosphoserine(CDC2)HMM predict
114MethylarginineHMM predict
117Phosphoserine(PKB)HMM predict
136Phosphotyrosine(EGFR)HMM predict
167Phosphothreonine(CDK)HMM predict
167Phosphothreonine(CDC2)HMM predict
217Phosphoserine(ATM)HMM predict
217Phosphoserine(IKK)HMM predict
233N-linkedHMM predict
234Phosphoserine(CK1)HMM predict
266Phosphoserine(IKK)HMM predict
266Phosphoserine(CK1)HMM predict
266Phosphoserine(ATM)HMM predict
281Phosphoserine(CK1)HMM predict
282N-linkedHMM predict
283Phosphoserine(CK1)HMM predict
285Phosphoserine(CK2)HMM predict
309N-linkedHMM predict
311Phosphoserine(CK2)HMM predict
371Phosphoserine(IKK)HMM predict
446Phosphotyrosine(EGFR)HMM predict
584Phosphoserine(CK2)HMM predict
585Phosphoserine(CK1)HMM predict
587Phosphotyrosine(INSR)HMM predict
589Phosphothreonine(PKC)HMM predict
599O-linkedHMM predict
601O-linkedHMM predict
601O-linkedHMM predict
601Phosphothreonine(MAPK)HMM predict
603O-linkedHMM predict
603Phosphothreonine(MAPK)HMM predict
607O-linkedHMM predict
611Phosphoserine(CDK)HMM predict
611O-linkedHMM predict
614Phosphoserine(IKK)HMM predict
614Phosphoserine(CDC2)HMM predict
687Phosphoserine(IKK)HMM predict
750Phosphoserine(ATM)HMM predict
825Phosphoserine(CDK)HMM predict
960Phosphotyrosine(INSR)HMM predict
989SulfotyrosineHMM predict
1033Phosphothreonine(PKC)HMM predict
1033Phosphothreonine(PKA)HMM predict
1072Phosphoserine(ATM)HMM predict
1085Phosphothreonine(PKA)HMM predict
1118Phosphoserine(PKA)HMM predict
1145Phosphothreonine(PKA)HMM predict
1222Phosphotyrosine(EGFR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001025107
  • Location:chr1 152821158-152867060
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 152866756 152867388 632 12
LIN9 G0GSE7516 152874198 152874548 350 7313
Oct1 H2O2-HelaGSE14283 152870360 152870406 46 3323
Oct1 HelaGSE14283 152870363 152870407 44 3325
Oct4 hESGSE17917 152866959 152867369 410 104
USF2 HepG2E 152866787 152867388 601 27
p130 QuiescentGSE19898 152866995 152867410 415 142
p130 SenescentGSE19898 152867041 152867446 405 183
p130 shRbQuiescentGSE19898 152866889 152867606 717 187
p130 shRbSenescentGSE19898 152866991 152867332 341 101
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 152866509 152866930 421 0
Gata2 K562GSE18868 152866171 152867273 1102 0
H3K4me2 HCT116GSE10453 152848018 152849078 1060 0
H3K4me3 colorectalcancer 152865518 152866408 890 0
H3ac HepG2E 152865518 152866343 825 0
Myc K562GSE19551 152866176 152867418 1242 0
PAX3-FKHR Rh4GSE19063 152863346 152864534 1188 0
RARA MCF7GSE15244 152865742 152866472 730 0
TAF k562GSE8489 152865518 152866374 856 0
USF1 HepG2E 152865652 152867388 1736 0
hScc1 BcellGSE12603 152866509 152866930 421 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-142-3p hsa-mir-142 17 21037424
hsa-miR-142-3p hsa-mir-142 17 16369484
hsa-miR-142-5p hsa-mir-142 17 21037424
hsa-miR-142-5p hsa-mir-142 17 16369484
hsa-miR-22 hsa-mir-22 17 21037424
hsa-miR-22* hsa-mir-22 17 21037424
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
128 Unknown MicroArray miR-1 ADAR n_a 15685193
1121 Unknown pSILAC miR-1 ADAR down 75-50% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000160710 "cardiac and skeletal muscles, cardiogenesis" n_a n_a "epithelium, squamous cell, leukocyte, lymphocyte, macrophage, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000160710 n_a n_a n_a "epithelium, squamous cell, leukocyte, lymphocyte, macrophage, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
1658 EST chr1 151379853 151380333 480 mRNA ADAR chr1 151367612 151393742 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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