AutismKB 2.0

Annotation Detail for DLC1


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Basic Information Top
Gene Symbol:DLC1 ( ARHGAP7,FLJ21120,HP,STARD12,p122-RhoGAP )
Gene Full Name: deleted in liver cancer 1
Band: 8p22
Quick LinksEntrez ID:10395; OMIM: 604258; Uniprot ID:RHG07_HUMAN; ENSEMBL ID: ENSG00000164741; HGNC ID: 2897
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
523Phosphoserine (By similarity).
526Phosphoserine (By similarity).
741Phosphoserine (By similarity).
742Phosphoserine (By similarity).
747Phosphoserine (By similarity).
749Phosphothreonine (By similarity).
750Phosphoserine (By similarity).
754Phosphoserine (By similarity).
755Phosphothreonine (By similarity).
850Phosphoserine (By similarity).
Location(AA) Modifications Resource
304Phosphoserine (By similarity).Swiss-Prot 53.0
305Phosphoserine (By similarity).Swiss-Prot 53.0
310Phosphoserine (By similarity).Swiss-Prot 53.0
312Phosphothreonine (By similarity).Swiss-Prot 53.0
313Phosphoserine (By similarity).Swiss-Prot 53.0
317Phosphoserine (By similarity).Swiss-Prot 53.0
318Phosphothreonine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
89Phosphoserine(CK2)HMM predict
89PhosphoserineHMM predict
129Phosphoserine(IKK)HMM predict
129Phosphoserine(CDC2)HMM predict
140Phosphoserine(CDC2)HMM predict
140O-linkedHMM predict
159Phosphoserine(CK1)HMM predict
161Phosphoserine(CK1)HMM predict
161Phosphoserine(CK2)HMM predict
165Phosphoserine(IKK)HMM predict
165Phosphoserine(CK1)HMM predict
168O-linkedHMM predict
173O-linkedHMM predict
178Phosphothreonine(MAPK)HMM predict
205Phosphoserine(MAPK)HMM predict
296Phosphoserine(CAMK2)HMM predict
296Phosphoserine(PKG)HMM predict
298Phosphoserine(IKK)HMM predict
298Phosphoserine(PKG)HMM predict
299N-linkedHMM predict
301O-linkedHMM predict
306O-linkedHMM predict
308Phosphoserine(IKK)HMM predict
308Phosphoserine(ATM)HMM predict
308Phosphoserine(CK1)HMM predict
310Phosphoserine(IKK)HMM predict
312O-linkedHMM predict
313Phosphoserine(CK1)HMM predict
314Phosphoserine(IKK)HMM predict
317O-linkedHMM predict
317Phosphoserine(IKK)HMM predict
317O-linkedHMM predict
318O-linkedHMM predict
318Phosphothreonine(MAPK)HMM predict
318O-linkedHMM predict
320Phosphoserine(CDC2)HMM predict
320Phosphoserine(CDK)HMM predict
327Phosphoserine(PKB)HMM predict
327Phosphoserine(IKK)HMM predict
346N-linkedHMM predict
351N-linkedHMM predict
352N-linkedHMM predict
363Phosphoserine(PKG)HMM predict
371SulfotyrosineHMM predict
387N-linkedHMM predict
391Phosphoserine(CDC2)HMM predict
418N-linkedHMM predict
419Phosphoserine(IKK)HMM predict
422Phosphoserine(CDC2)HMM predict
430N-linkedHMM predict
431Phosphoserine(PKA)HMM predict
431Phosphoserine(IKK)HMM predict
431Phosphoserine(PKG)HMM predict
432Phosphoserine(PKG)HMM predict
440Phosphoserine(CK1)HMM predict
491Phosphoserine(CK1)HMM predict
498Phosphoserine(IKK)HMM predict
502Phosphoserine(IKK)HMM predict
504Phosphoserine(IKK)HMM predict
508Phosphoserine(CK1)HMM predict
509Phosphoserine(CDC2)HMM predict
549Phosphoserine(PKA)HMM predict
549Phosphoserine(PKA)HMM predict
549Phosphoserine(PKG)HMM predict
575Phosphoserine(CK1)HMM predict
587Phosphoserine(IKK)HMM predict
707Phosphotyrosine(Syk)HMM predict
707Phosphotyrosine(INSR)HMM predict
806N-linkedHMM predict
807Phosphoserine(CK1)HMM predict
807PhosphoserineHMM predict
808Phosphoserine(CDC2)HMM predict
808PhosphoserineHMM predict
817Phosphoserine(PKG)HMM predict
859Phosphoserine(PKG)HMM predict
884SulfotyrosineHMM predict
912Phosphoserine(CK2)HMM predict
970Phosphoserine(ATM)HMM predict
975SulfotyrosineHMM predict
1045Phosphotyrosine(INSR)HMM predict
1077Phosphoserine(PKA)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006094
  • Location:chr8 12985242-13035179
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 12972967 12973062 95 12228
Myc K562GSE19551 12966822 12967314 492 18175
Rb QuiescentGSE19898 12982408 12982624 216 2727
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 13035069 13035227 158 0
CTCF CD4SISSRdata 13035069 13035227 158 0
CTCF G2GSE9613 13002265 13002612 347 0
CTCF G2GSE9613 13034538 13035267 729 0
ER Fulvestrant-MCF7GSE14664 13020607 13020645 38 0
FOXA1 DLD1GSE12801 12986454 12986938 484 0
FOXA1 MCF7GSE15244 13017686 13018493 807 0
FOXA1 MCF7GSE15244 13033202 13033738 536 0
FoxA1 MCF7MACSdata 13018113 13018331 218 0
Gata1 K562GSE18868 13007674 13008147 473 0
Gata2 K562GSE18868 13007655 13008294 639 0
H3K4me3 colorectalcancer 13033240 13033738 498 0
H3K4me3 colorectalcancer 13034052 13034674 622 0
H3ac HepG2E 13030754 13031688 934 0
H3ac HepG2E 13032285 13034744 2459 0
Nanog hESGSE18292 12993337 12993815 478 0
Oct1 H2O2-HelaGSE14283 13029255 13029302 47 0
PHF8 293TGSE20725 13034658 13035283 625 0
RARA MCF7GSE15244 13017942 13018417 475 0
RARG MCF7GSE15244 13017942 13018417 475 0
RARG MCF7GSE15244 13032812 13033738 926 0
hScc1 BcellGSE12603 13034608 13035267 659 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-141 hsa-mir-141 12 20967756
hsa-miR-141 hsa-mir-141 12 20967756
hsa-miR-141* hsa-mir-141 12 20967756
hsa-miR-141* hsa-mir-141 12 20967756
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
25094 HTC chr8 13236890 13244634 7744 mRNA DLC1 chr8 12985242 13416766 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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