Annotation Detail for PRMT5

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Basic Information Top

Gene Symbol:	PRMT5 ( HRMT1L5,IBP72,JBP1,SKB1,SKB1Hs )
Gene Full Name:	protein arginine methyltransferase 5
Band:	14q11.2
Quick Links	Entrez ID:10419; OMIM: 604045; Uniprot ID:ANM5_HUMAN; ENSEMBL ID: ENSG00000100462; HGNC ID: 10894
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:11 results

Location(AA)	Modification
2	N-acetylalanine.
200	N6-acetyllysine.

Location(AA)	Modification	Resource
103	Phosphoserine(PKG)	HMM predict
179	Sulfotyrosine	HMM predict
180	Phosphoserine(CK2)	HMM predict
288	Phosphoserine(ATM)	HMM predict
324	Phosphotyrosine(Syk)	HMM predict
324	Phosphotyrosine(SRC)	HMM predict
324	Phosphotyrosine(EGFR)	HMM predict
414	Phosphothreonine(PKC)	HMM predict
537	Phosphothreonine(PKC)	HMM predict
627	N-linked	HMM predict
627	Asparagine	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001039619
Location:chr14 22459572-22468500
strand:-

Upstream the gene:16 results
Downstream the gene:1 results
Inside the gene:18 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	22469226	22469751	525	988
ER	E2-MCF7	GSE14664	22471531	22471567	36	3049
ER	Fulvestrant-MCF7	GSE14664	22471534	22471568	34	3051
Fos	K562	GSE19551	22468278	22469464	1186	371
P300	T30-glioblastoma	GSE21026	22467682	22469859	2177	270
PHF8	Hs68minusFBS	GSE20725	22467938	22469816	1878	377
PHF8	Hs68plusFBS	GSE20725	22467663	22469908	2245	285
Pol3	K562	GSE19551	22468320	22469031	711	175
RARG	MCF7	GSE15244	22468270	22468907	637	88
RARG	MCF7	GSE15244	22469298	22469751	453	1024
Rb	Growing	GSE19898	22468466	22468649	183	57
Rb	Growing	GSE19898	22468758	22468913	155	335
USF2	HepG2	E	22468697	22469751	1054	724
hScc1	Bcell	GSE12603	22469336	22469751	415	1043
hScc1	CdLS	GSE12603	22469298	22469751	453	1024
p130	Senescent	GSE19898	22468218	22468793	575	5

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
RARG	MCF7	GSE15244	22459195	22459638	443	156

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3K4me2	HCT116	GSE10453	22467281	22468106	825	0
H3K4me3	colorectal	cancer	22467323	22468068	745	0
H3ac	HepG2	E	22465337	22466021	684	0
H3ac	HepG2	E	22467071	22469751	2680	0
NRSF	mAb	Jurkat	22467245	22467621	376	0
PHF8	293T	GSE20725	22467836	22469065	1229	0
PHF8	HeLa	GSE20725	22467755	22468828	1073	0
RARG	MCF7	GSE15244	22460991	22461600	609	0
RARG	MCF7	GSE15244	22466461	22466731	270	0
RARG	MCF7	GSE15244	22467555	22467987	432	0
TAF	Hela	GSE8489	22466461	22466731	270	0
TAF	Hela	GSE8489	22467071	22468026	955	0
TAF	k562	GSE8489	22460955	22461600	645	0
TAF	k562	GSE8489	22465145	22466091	946	0
TAF	k562	GSE8489	22466461	22466731	270	0
TAF	k562	GSE8489	22467071	22469604	2533	0
p130	shRbQuiescent	GSE19898	22467882	22469016	1134	0
p130	shRbSenescent	GSE19898	22468086	22468772	686	0

Validated miRNA targets

miR Walk:15 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-182	hsa-mir-182	7	19167416
hsa-miR-182*	hsa-mir-182	7	19167416
hsa-miR-200a	hsa-mir-200a	1	19167416
hsa-miR-200a*	hsa-mir-200a	1	19167416
hsa-miR-200b	hsa-mir-200b	1	19167416
hsa-miR-200b*	hsa-mir-200b	1	19167416
hsa-miR-200c	hsa-mir-200c	12	19167416
hsa-miR-200c*	hsa-mir-200c	12	19167416
hsa-miR-21	hsa-mir-21	17	19167416
hsa-miR-21*	hsa-mir-21	17	19167416
hsa-miR-34a	hsa-mir-34a	1	19167416
hsa-miR-34a*	hsa-mir-34a	1	19167416
hsa-miR-429	hsa-mir-429	1	19167416
hsa-miR-96	hsa-mir-96	7	19167416
hsa-miR-96*	hsa-mir-96	7	19167416

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
7676	mRNA		chr14	22458504	22462450	637	mRNA	SKB1	chr14	22459578	22468501	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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