AutismKB 2.0

Annotation Detail for MERTK


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Basic Information Top
Gene Symbol:MERTK ( MER,MGC133349,RP38,c-mer )
Gene Full Name: c-mer proto-oncogene tyrosine kinase
Band: 2q13
Quick LinksEntrez ID:10461; OMIM: 604705; Uniprot ID:MERTK_HUMAN; ENSEMBL ID: ENSG00000153208; HGNC ID: 7027
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
114N-linked (GlcNAc...) (Potential).
170N-linked (GlcNAc...) (Potential).
207N-linked (GlcNAc...) (Potential).
215N-linked (GlcNAc...) (Potential).
234N-linked (GlcNAc...) (Potential).
294N-linked (GlcNAc...) (Potential).
316N-linked (GlcNAc...) (Potential).
329N-linked (GlcNAc...) (Potential).
336N-linked (GlcNAc...) (Potential).
354N-linked (GlcNAc...) (Potential).
389N-linked (GlcNAc...) (Potential).
395N-linked (GlcNAc...) (Potential).
442N-linked (GlcNAc...).
454N-linked (GlcNAc...) (Potential).
543Phosphoserine.
613Phosphoserine.
754Phosphotyrosine; by autocatalysis (By
929Phosphotyrosine.
935Phosphoserine.
968Phosphoserine.
970Phosphoserine.
979Phosphoserine.
Location(AA) Modifications Resource
114N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
170N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
207N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
215N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
234N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
294N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
316N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
329N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
336N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
354N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
389N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
395N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
442N-linked (GlcNAc...).Swiss-Prot 53.0
454N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
749Phosphotyrosine (Mer)Phospho.ELM 6.0
753Phosphotyrosine (Mer)Phospho.ELM 6.0
754Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
754Phosphotyrosine (Mer)Phospho.ELM 6.0
Location(AA) Modification Resource
42O-linkedHMM predict
48Phosphothreonine(CDK)HMM predict
48Phosphothreonine(MAPK)HMM predict
66Phosphoserine(ATM)HMM predict
68PhosphothreonineHMM predict
84O-linkedHMM predict
123Phosphotyrosine(EGFR)HMM predict
159O-linkedHMM predict
190Phosphotyrosine(Jak)HMM predict
190Phosphotyrosine(INSR)HMM predict
207N-linkedHMM predict
211N-linkedHMM predict
215N-linkedHMM predict
234N-linkedHMM predict
239N-linkedHMM predict
273Phosphoserine(ATM)HMM predict
294N-linkedHMM predict
311Phosphotyrosine(EGFR)HMM predict
336N-linkedHMM predict
367C-linkedHMM predict
378O-linkedHMM predict
384O-linkedHMM predict
389N-linkedHMM predict
395N-linkedHMM predict
400N-linkedHMM predict
442N-linkedHMM predict
449Phosphoserine(PKG)HMM predict
454N-linkedHMM predict
493O-linkedHMM predict
508S-palmitoylHMM predict
625N-linkedHMM predict
661Phosphoserine(ATM)HMM predict
789O-linkedHMM predict
907O-linkedHMM predict
913Phosphoserine(PKG)HMM predict
970Phosphoserine(IKK)HMM predict
992Phosphoserine(CK1)HMM predict
995Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006343
  • Location:chr2 112372661-112503415
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 112368741 112368907 166 3838
CTCF G2GSE9613 112371480 112371624 144 1110
Myc hESGSE17917 112371925 112372391 466 504
hScc1 BcellGSE12603 112371939 112372311 372 537
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 112506015 112506292 277 2738
Nanog hESGSE18292 112505676 112505990 314 2418
Oct1 H2O2-HelaGSE14283 112512202 112512233 31 8802
Sox2 hESGSE18292 112505716 112505987 271 2436
TFAP2C MCF7GSE21234 112515242 112516020 778 12216
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 112374857 112375404 547 0
CTCF G2GSE9613 112416096 112416353 257 0
ER MCF7GSE19013 112406692 112407494 802 0
ER MCF7GSE19013 112414379 112414914 535 0
ER MCF7GSE19013 112444674 112445034 360 0
FOXA1 MCF7GSE15244 112392284 112392959 675 0
FOXA1 MCF7GSE15244 112418932 112419259 327 0
FOXA1 MCF7GSE15244 112420237 112421010 773 0
FOXA1 MCF7GSE15244 112458473 112459038 565 0
Fos K562GSE19551 112495633 112496336 703 0
FoxA1 MCF7MACSdata 112406981 112407272 291 0
H3K4me3 colorectalcancer 112373880 112374636 756 0
H3ac HepG2E 112373348 112373541 193 0
H3ac HepG2E 112373880 112374857 977 0
NRSF mAbJurkat 112400801 112401115 314 0
Oct1 H2O2-HelaGSE14283 112421120 112421169 49 0
Oct1 HelaGSE14283 112421121 112421169 48 0
Oct1 HelaGSE14283 112475573 112475604 31 0
Oct1 HelaGSE14283 112493041 112493069 28 0
Oct1 HelaGSE14283 112497965 112498004 39 0
P300 T0-glioblastomaGSE21026 112449161 112449712 551 0
P300 T30-glioblastomaGSE21026 112380019 112380897 878 0
P300 T30-glioblastomaGSE21026 112449082 112449724 642 0
RARA MCF7GSE15244 112407133 112407529 396 0
RARA MCF7GSE15244 112420165 112421010 845 0
RARA MCF7GSE15244 112458473 112459222 749 0
Rb QuiescentGSE19898 112392500 112392695 195 0
Rb shRbQuiescentGSE19898 112392536 112392736 200 0
SRF GMOGSE8489 112459330 112459537 207 0
Stat6 IL-4-hr4GSE17850 112471454 112471944 490 0
TAF HelaGSE8489 112456666 112456807 141 0
TFAP2C MCF7GSE21234 112420669 112421289 620 0
TFAP2C MCF7GSE21234 112440710 112441292 582 0
TFAP2C MCF7GSE21234 112460146 112460477 331 0
USF1 HepG2E 112448975 112449780 805 0
USF2 HepG2E 112448975 112449780 805 0
hScc1 G2GSE9613 112374857 112375467 610 0
p130 QuiescentGSE19898 112392392 112392697 305 0
p130 SenescentGSE19898 112392492 112392830 338 0
p63 keratinocytesGSE17611 112386549 112387228 679 0
p63 keratinocytesGSE17611 112449083 112449928 845 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-126 hsa-mir-126 9 18185580
hsa-miR-126* hsa-mir-126 9 18185580
hsa-miR-335 hsa-mir-335 7 18185580
hsa-miR-335* hsa-mir-335 7 18185580
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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