Annotation Detail for CREB3

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Basic Information Top

Gene Symbol:	CREB3 ( LUMAN,LZIP,MGC15333,MGC19782 )
Gene Full Name:	cAMP responsive element binding protein 3
Band:	9p13.3
Quick Links	Entrez ID:10488; OMIM: 606443; Uniprot ID:CREB3_HUMAN; ENSEMBL ID: ENSG00000107175; HGNC ID: 2347
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:5 results
Experimental PTM Sites from dbPTM:2 results
Predicted PTM Sites by profile HMM from dbPTM:10 results

Location(AA)	Modification
17	LXXLL motif 1.
58	LXXLL motif 2.
81	HCFC1-binding-motif (HBM).
331	N-linked (GlcNAc...) (Potential).
372	N-linked (GlcNAc...) (Potential).

Location(AA)	Modification	Resource
59	Phosphoserine(MAPK)	HMM predict
81	Phosphotyrosine	HMM predict
129	Phosphothreonine(MAPK)	HMM predict
129	Phosphothreonine(CDC2)	HMM predict
187	Phosphoserine(PKG)	HMM predict
229	Phosphoserine(CK1)	HMM predict
246	N-linked	HMM predict
249	O-linked	HMM predict
372	N-linked	HMM predict
384	Phosphoserine(CDC2)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_006368
Location:chr9 35722316-35727003
strand:+

Upstream the gene:1 results
Downstream the gene:0 results
Inside the gene:8 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
ETS1	Jurkat	GSE17954	35721567	35723015	1448	26

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	35726054	35726398	344	0
CTCF	CD4	SISSRdata	35726054	35726398	344	0
H3ac	HepG2	E	35722571	35723327	756	0
PHF8	HeLa	GSE20725	35721551	35723097	1546	0
Rb	Quiescent	GSE19898	35722091	35722785	694	0
Rb	Senescent	GSE19898	35722094	35722890	796	0
hScc1	Bcell	GSE12603	35726258	35726493	235	0
p130	shRbSenescent	GSE19898	35722145	35723068	923	0

Validated miRNA targets

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
26381	mRNA	CREB3	chr9	35722316	35727004	141	mRNA	GBA2	chr9	35726863	35739225	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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