AutismKB 2.0

Annotation Detail for SORBS1


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Basic Information Top
Gene Symbol:SORBS1 ( CAP,DKFZp451C066,DKFZp586P1422,FLAF2,FLJ12406,KIAA1296,R85FL,SH3D5,SH3P12,SORB1 )
Gene Full Name: sorbin and SH3 domain containing 1
Band: 10q24.1
Quick LinksEntrez ID:10580; OMIM: 605264; Uniprot ID:SRBS1_HUMAN; ENSEMBL ID: ENSG00000095637; HGNC ID: 14565
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
79Phosphotyrosine.
86Phosphoserine.
89Phosphoserine.
134Phosphotyrosine (By similarity).
349Phosphothreonine (By similarity).
472Phosphoserine.
481Phosphoserine (By similarity).
497Phosphothreonine (By similarity).
556Phosphoserine (By similarity).
640Phosphoserine (By similarity).
665Phosphoserine.
862Phosphothreonine.
945Phosphoserine.
953Phosphoserine.
Location(AA) Modifications Resource
89Phosphoserine (By similarity).Swiss-Prot 53.0
349Phosphothreonine (By similarity).Swiss-Prot 53.0
481Phosphoserine (By similarity).Swiss-Prot 53.0
497Phosphothreonine (By similarity).Swiss-Prot 53.0
556Phosphoserine (By similarity).Swiss-Prot 53.0
640Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
35Phosphoserine(PKG)HMM predict
72Phosphothreonine(PKC)HMM predict
77Phosphoserine(CK1)HMM predict
79Phosphotyrosine(EGFR)HMM predict
82O-linkedHMM predict
82Phosphothreonine(MAPK)HMM predict
84O-linkedHMM predict
85O-linkedHMM predict
85O-linkedHMM predict
86O-linkedHMM predict
86Phosphoserine(CDC2)HMM predict
86Phosphoserine(ATM)HMM predict
89Phosphoserine(CDC2)HMM predict
89Phosphoserine(IKK)HMM predict
115Phosphoserine(CK2)HMM predict
146Phosphoserine(IKK)HMM predict
151Phosphoserine(CK1)HMM predict
151Phosphoserine(CK2)HMM predict
152O-linkedHMM predict
181Phosphothreonine(CDK)HMM predict
191O-linkedHMM predict
195O-linkedHMM predict
197Phosphoserine(IKK)HMM predict
200O-linkedHMM predict
235O-linkedHMM predict
235Phosphoserine(ATM)HMM predict
237Phosphothreonine(MAPK)HMM predict
240O-linkedHMM predict
242O-linkedHMM predict
242Phosphoserine(ATM)HMM predict
259Phosphoserine(CAMK2)HMM predict
269O-linkedHMM predict
270O-linkedHMM predict
273Phosphoserine(IKK)HMM predict
295O-linkedHMM predict
303O-linkedHMM predict
304O-linkedHMM predict
305O-linkedHMM predict
308N-linkedHMM predict
325Phosphoserine(CK1)HMM predict
326Phosphoserine(IKK)HMM predict
328Phosphoserine(CK1)HMM predict
328Phosphoserine(ATM)HMM predict
344Phosphothreonine(PKC)HMM predict
350Phosphoserine(CDC2)HMM predict
350Phosphoserine(CDK)HMM predict
350PhosphoserineHMM predict
415Phosphotyrosine(SRC)HMM predict
415Phosphotyrosine(Syk)HMM predict
430Phosphothreonine(CK2)HMM predict
437Phosphotyrosine(INSR)HMM predict
437Phosphotyrosine(Syk)HMM predict
437SulfotyrosineHMM predict
438Phosphothreonine(MAPK)HMM predict
447Phosphothreonine(MAPK)HMM predict
449Phosphoserine(CDC2)HMM predict
449Phosphoserine(MAPK)HMM predict
452Phosphoserine(CK2)HMM predict
452Phosphoserine(IKK)HMM predict
460Phosphotyrosine(INSR)HMM predict
465Phosphoserine(CK2)HMM predict
472Phosphoserine(IKK)HMM predict
479Phosphoserine(IKK)HMM predict
497Phosphothreonine(PKA)HMM predict
506Phosphoserine(PKA)HMM predict
506Phosphoserine(CK1)HMM predict
506Phosphoserine(IKK)HMM predict
506Phosphoserine(PKB)HMM predict
510Phosphoserine(CK1)HMM predict
510Phosphoserine(CDC2)HMM predict
556Phosphoserine(ATM)HMM predict
556PhosphoserineHMM predict
636O-linkedHMM predict
637O-linkedHMM predict
637O-linkedHMM predict
637O-linkedHMM predict
640Phosphoserine(CDC2)HMM predict
640Phosphoserine(MAPK)HMM predict
642O-linkedHMM predict
646O-linkedHMM predict
647O-linkedHMM predict
652SulfotyrosineHMM predict
682Phosphotyrosine(Syk)HMM predict
703Phosphoserine(CK2)HMM predict
704Phosphoserine(IKK)HMM predict
705O-linkedHMM predict
708Phosphothreonine(CK2)HMM predict
713Phosphoserine(ATM)HMM predict
713PhosphoserineHMM predict
762Phosphothreonine(PKA)HMM predict
791Phosphoserine(IKK)HMM predict
808Phosphothreonine(PKC)HMM predict
937SulfotyrosineHMM predict
943Phosphoserine(CDC2)HMM predict
945Phosphoserine(CDC2)HMM predict
945Phosphoserine(CDK)HMM predict
951O-linkedHMM predict
953Phosphoserine(CDC2)HMM predict
964O-linkedHMM predict
964Phosphothreonine(MAPK)HMM predict
968O-linkedHMM predict
969Phosphoserine(IKK)HMM predict
973O-linkedHMM predict
1004Phosphothreonine(CDK)HMM predict
1028Phosphoserine(MAPK)HMM predict
1028Phosphoserine(CDK)HMM predict
1030O-linkedHMM predict
1030Phosphoserine(IKK)HMM predict
1032Phosphoserine(CK1)HMM predict
1034Phosphoserine(CK1)HMM predict
1045Phosphothreonine(MAPK)HMM predict
1048Phosphoserine(IKK)HMM predict
1051Phosphoserine(CDC2)HMM predict
1051Phosphoserine(MAPK)HMM predict
1068Phosphoserine(IKK)HMM predict
1082Phosphothreonine(CDK)HMM predict
1167Phosphoserine(CK2)HMM predict
1171Phosphothreonine(MAPK)HMM predict
1193Phosphothreonine(PKC)HMM predict
1204MethylarginineHMM predict
1209MethylarginineHMM predict
1212Phosphoserine(PKA)HMM predict
1212Phosphoserine(ATM)HMM predict
1223Phosphothreonine(PKA)HMM predict
1223Phosphothreonine(PKC)HMM predict
1223Phosphothreonine(MAPK)HMM predict
1223Phosphothreonine(CDK)HMM predict
1227Phosphoserine(ATM)HMM predict
1229Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001034954
  • Location:chr10 97061519-97190926
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 97058407 97058931 524 2851
Nanog hESGSE18292 97054186 97054582 396 7136
P300 T30-glioblastomaGSE21026 97057394 97059315 1921 3165
RARA MCF7GSE15244 97058279 97058604 325 3078
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 97124469 97124662 193 0
CTCF CD4GSE12889 97180173 97180408 235 0
CTCF CD4SISSRdata 97124469 97124662 193 0
CTCF CD4SISSRdata 97180173 97180408 235 0
Fos K562GSE19551 97143755 97144325 570 0
Myc K562GSE19551 97124463 97124669 206 0
NRSF JurkatGSE13047 97141611 97142276 665 0
NRSF JurkatGSE13047 97161392 97161924 532 0
NRSF JurkatSISSRdata 97141722 97142048 326 0
NRSF mAbJurkat 97123239 97124421 1182 0
NRSF mAbJurkat 97139654 97140298 644 0
NRSF mAbJurkat 97140834 97144512 3678 0
NRSF mAbJurkat 97159307 97164165 4858 0
NRSF-mono JurkatQuESTdata 97141610 97142275 665 0
NRSF-mono JurkatQuESTdata 97161428 97161862 434 0
NRSF-poly JurkatQuESTdata 97141573 97142203 630 0
NRSF-poly JurkatQuESTdata 97161412 97161789 377 0
P300 T30-glioblastomaGSE21026 97068654 97069610 956 0
P300 T30-glioblastomaGSE21026 97083706 97085046 1340 0
Rb GrowingGSE19898 97084067 97084380 313 0
TAF k562GSE8489 97070440 97070983 543 0
TAFII hESGSE17917 97124350 97124730 380 0
TFAP2C MCF7GSE21234 97069001 97069451 450 0
USF2 HepG2E 97096431 97097157 726 0
hScc1 BcellGSE12603 97112105 97113682 1577 0
hScc1 BcellGSE12603 97124212 97124830 618 0
hScc1 BcellGSE12603 97180235 97180649 414 0
hScc1 CdLSGSE12603 97112251 97113580 1329 0
hScc1 CdLSGSE12603 97124070 97125211 1141 0
hScc1 CdLSGSE12603 97180235 97180784 549 0
hScc1 G2GSE9613 97112825 97113540 715 0
hScc1 G2GSE9613 97124212 97124967 755 0
hScc1 G2GSE9613 97180235 97180649 414 0
p130 QuiescentGSE19898 97083974 97084447 473 0
p130 SenescentGSE19898 97083945 97084385 440 0
p130 SenescentGSE19898 97084531 97084967 436 0
p130 shRbQuiescentGSE19898 97083778 97084482 704 0
p130 shRbSenescentGSE19898 97084074 97084461 387 0
p130 shRbSenescentGSE19898 97113064 97113290 226 0
p63 keratinocytesGSE17611 97107815 97108928 1113 0
p63 keratinocytesGSE17611 97179162 97180070 908 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
3505 EST chr10 97272264 97272790 526 mRNA SORBS1 chr10 97061520 97311125 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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