Annotation Detail for PDLIM5

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Basic Information Top

Gene Symbol:	PDLIM5 ( ENH,ENH1,LIM )
Gene Full Name:	PDZ and LIM domain 5
Band:	4q22.3
Quick Links	Entrez ID:10611; OMIM: 605904; Uniprot ID:PDLI5_HUMAN; ENSEMBL ID: ENSG00000163110; HGNC ID: 17468
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
2	N-acetylserine.
110	Phosphothreonine.
111	Phosphoserine.
134	Phosphoserine.
136	Phosphoserine.
137	Phosphoserine.
228	Phosphoserine (By similarity).
251	Phosphotyrosine.
309	Phosphoserine.
313	Phosphoserine.
335	Phosphoserine (By similarity).

Location(AA)	Modifications	Resource
2	N-acetylserine.	Swiss-Prot 53.0
228	Phosphoserine (By similarity).	Swiss-Prot 53.0
250	Phosphotyrosine	Phospho.ELM 6.0
308	Phosphoserine	Phospho.ELM 6.0
309	Phosphoserine.	Swiss-Prot 53.0
312	Phosphoserine	Phospho.ELM 6.0
313	Phosphoserine.	Swiss-Prot 53.0
335	Phosphoserine (By similarity).	Swiss-Prot 53.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
AR	prostate-cancer	GSE14092	95819991	95820863	872	12029

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	CD4	GSE12889	95761706	95761954	248
CTCF	CD4	SISSRdata	95761706	95761954	248
CTCF	G2	GSE9613	95746539	95746821	282
CTCF	G2	GSE9613	95761652	95761941	289
CTCF	G2	GSE9613	95779465	95779640	175
ER	MCF7	GSE19013	95806048	95806649	601
hScc1	Bcell	GSE12603	95736086	95736429	343
hScc1	Bcell	GSE12603	95761689	95761973	284
hScc1	CdLS	GSE12603	95735907	95736635	728

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-223	hsa-mir-223	X	19017354
hsa-miR-223*	hsa-mir-223	X	19017354
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
979	Unknown	pSILAC	miR-155	PDLIM5	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000163110		n_a	n_a	n_a	"epithelium, leukocyte, lymphocyte, macrophage, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma, "

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
19985	mRNA	PDLIM5	chr4	95730215	95946554	1535	EST		chr4	95874503	95876038	Non-exonic Bidirectional (NOB) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018