AutismKB 2.0

Annotation Detail for CENPE


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Basic Information Top
Gene Symbol:CENPE ( KIF10 )
Gene Full Name: centromere protein E, 312kDa
Band: 4q24
Quick LinksEntrez ID:1062; OMIM: 117143; Uniprot ID:CENPE_HUMAN; ENSEMBL ID: ENSG00000138778; HGNC ID: 1856
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
22Phosphoserine.
422Phosphothreonine.
454Phosphoserine.
544Phosphothreonine.
611Phosphoserine.
1026Phosphothreonine.
1211Phosphoserine.
1268Phosphothreonine.
2389Phosphoserine.
2513Phosphoserine.
2639Phosphoserine.
2647Phosphoserine.
2651Phosphoserine.
2654Phosphoserine.
2698Cysteine methyl ester (Probable).
Location(AA) Modifications Resource
422Phosphothreonine.Swiss-Prot 53.0
422PhosphothreoninePhospho.ELM 6.0
454PhosphoserinePhospho.ELM 6.0
454Phosphoserine.Swiss-Prot 53.0
544Phosphothreonine.Swiss-Prot 53.0
611Phosphoserine.Swiss-Prot 53.0
611PhosphoserinePhospho.ELM 6.0
1211Phosphoserine.Swiss-Prot 53.0
1211PhosphoserinePhospho.ELM 6.0
1268PhosphothreoninePhospho.ELM 6.0
1268Phosphothreonine.Swiss-Prot 53.0
2570PhosphoserinePhospho.ELM 6.0
2601Phosphoserine.Swiss-Prot 53.0
2601PhosphoserinePhospho.ELM 6.0
2613PhosphoserinePhospho.ELM 6.0
2613Phosphoserine.Swiss-Prot 53.0
2616PhosphoserinePhospho.ELM 6.0
2616Phosphoserine.Swiss-Prot 53.0
2660S-farnesyl cysteine.Swiss-Prot 53.0
Location(AA) Modification Resource
22Phosphoserine(CK1)HMM predict
22Phosphoserine(IKK)HMM predict
56N-linkedHMM predict
61N-linkedHMM predict
63Phosphotyrosine(Syk)HMM predict
79N-linkedHMM predict
94Phosphotyrosine(INSR)HMM predict
136N-linkedHMM predict
173Phosphotyrosine(Abl)HMM predict
229Phosphoserine(PKG)HMM predict
334Phosphotyrosine(Jak)HMM predict
396N-linkedHMM predict
422Phosphothreonine(PKA)HMM predict
436Phosphotyrosine(Syk)HMM predict
445N-linkedHMM predict
464Phosphoserine(CK2)HMM predict
480Phosphoserine(CK1)HMM predict
519Phosphothreonine(PKC)HMM predict
519Phosphothreonine(CK2)HMM predict
578Phosphoserine(CK1)HMM predict
597Phosphotyrosine(INSR)HMM predict
600Phosphoserine(ATM)HMM predict
613Phosphoserine(CK1)HMM predict
674Phosphoserine(ATM)HMM predict
808O-linkedHMM predict
901Phosphoserine(IKK)HMM predict
905Phosphothreonine(PKC)HMM predict
982Phosphothreonine(PKC)HMM predict
1151Phosphoserine(CK1)HMM predict
1192Phosphotyrosine(Syk)HMM predict
1233Phosphothreonine(PKC)HMM predict
1257Phosphoserine(PKG)HMM predict
1259Phosphoserine(CAMK2)HMM predict
1316O-linkedHMM predict
1340Phosphoserine(ATM)HMM predict
1384Phosphoserine(CK1)HMM predict
1397N-linkedHMM predict
1475Phosphothreonine(CK2)HMM predict
1529Phosphotyrosine(Syk)HMM predict
1581Phosphoserine(CK2)HMM predict
1581PhosphoserineHMM predict
1581Phosphoserine(ATM)HMM predict
1623PhosphoserineHMM predict
1623Phosphoserine(ATM)HMM predict
1623Phosphoserine(PKG)HMM predict
1628Phosphotyrosine(SRC)HMM predict
1637N-linkedHMM predict
1693Phosphoserine(CK2)HMM predict
1693Phosphoserine(CK1)HMM predict
1840N-linkedHMM predict
1939Phosphothreonine(PKC)HMM predict
1964Phosphoserine(CK2)HMM predict
2081Phosphoserine(CK1)HMM predict
2211Phosphoserine(CK2)HMM predict
2285Phosphothreonine(PKC)HMM predict
2310Phosphothreonine(PKC)HMM predict
2322N-linkedHMM predict
2328N-linkedHMM predict
2351Phosphoserine(CK1)HMM predict
2486O-linkedHMM predict
2519Phosphoserine(CK1)HMM predict
2570Phosphoserine(CDC2)HMM predict
2578Phosphoserine(CAMK2)HMM predict
2613Phosphoserine(PKB)HMM predict
2613PhosphoserineHMM predict
2613Phosphoserine(CK1)HMM predict
2613Phosphoserine(PKA)HMM predict
2613Phosphoserine(IKK)HMM predict
2616Phosphoserine(MAPK)HMM predict
2625N-linkedHMM predict
2644Phosphoserine(IKK)HMM predict
2644Phosphoserine(ATM)HMM predict
2644Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001813
  • Location:chr4 104246411-104339014
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 104338539 104339563 1024 37
H3K4me3 colorectalcancer 104339049 104339465 416 243
LIN54 G0GSE7516 104338615 104339430 815 8
Myc K562GSE19551 104348233 104348677 444 9441
Nanog hESGSE18292 104344864 104345100 236 5968
Oct4 hESGSE17917 104338798 104339241 443 5
P300 T30-glioblastomaGSE21026 104338607 104339642 1035 110
USF2 HepG2E 104339049 104339563 514 292
p130 shRbSenescentGSE19898 104338454 104339592 1138 9
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 104308748 104309036 288 0
CTCF G2GSE9613 104338495 104339242 747 0
H3K4me3 colorectalcancer 104337867 104338204 337 0
H3ac HepG2E 104337581 104338424 843 0
LIN9 G0GSE7516 104338316 104339563 1247 0
LIN9 SGSE7516 104337791 104339563 1772 0
Oct1 H2O2-HelaGSE14283 104304858 104304886 28 0
Oct1 H2O2-HelaGSE14283 104305062 104305093 31 0
Oct1 HelaGSE14283 104276809 104276845 36 0
Oct1 HelaGSE14283 104304857 104304886 29 0
Oct1 HelaGSE14283 104314986 104315018 32 0
PHF8 HeLaGSE20725 104338390 104339341 951 0
p130 QuiescentGSE19898 104338466 104339520 1054 0
p130 SenescentGSE19898 104338232 104339516 1284 0
p130 shRbQuiescentGSE19898 104338497 104339476 979 0
p130 G0GSE7516 104338424 104339563 1139 0
p130 SGSE7516 104338316 104339563 1247 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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