Annotation Detail for TXNIP

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Basic Information Top

Gene Symbol:	TXNIP ( EST01027,HHCPA78,THIF,VDUP1 )
Gene Full Name:	thioredoxin interacting protein
Band:	1q21.1
Quick Links	Entrez ID:10628; OMIM: 606599; Uniprot ID:TXNIP_HUMAN; ENSEMBL ID: ENSG00000117289; HGNC ID: 16952
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:16 results

Location(AA)	Modification
349	Phosphothreonine.
361	Phosphoserine.

Location(AA)	Modification	Resource
21	Phosphotyrosine(SRC)	HMM predict
23	Phosphoserine(CDK)	HMM predict
133	Phosphoserine(CK1)	HMM predict
304	O-linked	HMM predict
304	O-linked	HMM predict
307	Phosphoserine(CK2)	HMM predict
308	Phosphoserine(PKA)	HMM predict
308	Phosphoserine(IKK)	HMM predict
308	Phosphoserine(PKB)	HMM predict
314	Phosphoserine(CK1)	HMM predict
318	Phosphoserine(IKK)	HMM predict
349	Phosphothreonine(CDK)	HMM predict
358	Phosphoserine(ATM)	HMM predict
378	Phosphotyrosine(SRC)	HMM predict
378	Tyrosine	HMM predict
378	Phosphotyrosine(Abl)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_006472
Location:chr1 144149938-144153879
strand:+

Upstream the gene:14 results
Downstream the gene:3 results
Inside the gene:5 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
FOXA1	MCF7	GSE15244	144149239	144149792	553	423
Fos	K562	GSE19551	144148978	144150564	1586	168
FoxA1	MCF7	MACSdata	144149575	144149866	291	218
H3K4me3	colorectal	cancer	144148360	144148918	558	1300
H3ac	HepG2	E	144146369	144146738	369	3385
H3ac	HepG2	E	144148286	144149646	1360	973
P300	T0-glioblastoma	GSE21026	144149271	144150219	948	194
P300	T30-glioblastoma	GSE21026	144149038	144150304	1266	268
PHF8	Hs68minusFBS	GSE20725	144149345	144150093	748	220
RARA	MCF7	GSE15244	144146369	144147115	746	3197
TAF	k562	GSE8489	144147943	144149502	1559	1216
TFAP2C	MCF7	GSE21234	144144827	144145178	351	4936
p130	shRbQuiescent	GSE19898	144149370	144149761	391	373
p130	shRbSenescent	GSE19898	144149406	144149691	285	390

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Pol2	GM12878	GSE19551	144154050	144154954	904	623
RARA	MCF7	GSE15244	144158121	144158667	546	4515
RARA	MCF7	GSE15244	144159766	144160463	697	6235

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3K4me3	colorectal	cancer	144150115	144152326	2211	0
H3ac	HepG2	E	144150016	144152761	2745	0
TAF	Hela	GSE8489	144150860	144151316	456	0
TAF	k562	GSE8489	144149978	144152371	2393	0
TAF	k562	GSE8489	144152847	144153729	882	0

Validated miRNA targets

miR Walk:4 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-17	hsa-mir-17	13	20656682
hsa-miR-17*	hsa-mir-17	13	20656682
hsa-miR-373	hsa-mir-373	19	21271679
hsa-miR-373*	hsa-mir-373	19	21271679

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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