AutismKB 2.0

Annotation Detail for GAS2L1


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Basic Information Top
Gene Symbol:GAS2L1 ( GAR22,MGC17243 )
Gene Full Name: growth arrest-specific 2 like 1
Band: 22q12.2
Quick LinksEntrez ID:10634; OMIM: 602128; Uniprot ID:GA2L1_HUMAN; ENSEMBL ID: ENSG00000185340; HGNC ID: 16955
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
193Phosphothreonine.
297Phosphoserine.
306Phosphoserine.
352Phosphoserine.
384Phosphoserine.
391Phosphothreonine.
394Phosphoserine.
436Phosphoserine.
438Phosphoserine.
489Phosphoserine.
490Phosphoserine.
492Phosphoserine.
498Phosphothreonine.
Location(AA) Modifications Resource
384Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
184O-linkedHMM predict
193Phosphothreonine(CDK)HMM predict
193Phosphothreonine(CDC2)HMM predict
193Phosphothreonine(MAPK)HMM predict
263Phosphothreonine(PKC)HMM predict
267SulfotyrosineHMM predict
292Phosphoserine(CDC2)HMM predict
297O-linkedHMM predict
297Phosphoserine(CDC2)HMM predict
297Phosphoserine(IKK)HMM predict
299O-linkedHMM predict
299O-linkedHMM predict
301O-linkedHMM predict
301PhosphoserineHMM predict
301Phosphoserine(CDC2)HMM predict
301Phosphoserine(CDK)HMM predict
306Phosphoserine(IKK)HMM predict
306Phosphoserine(CDC2)HMM predict
306Phosphoserine(MAPK)HMM predict
306PhosphoserineHMM predict
311O-linkedHMM predict
316Phosphoserine(PKG)HMM predict
316Phosphoserine(PKA)HMM predict
316Phosphoserine(IKK)HMM predict
334Phosphothreonine(CDC2)HMM predict
334Phosphothreonine(MAPK)HMM predict
334Phosphothreonine(CDK)HMM predict
352Phosphoserine(IKK)HMM predict
352Phosphoserine(CK2)HMM predict
352Phosphoserine(CAMK2)HMM predict
357Phosphoserine(IKK)HMM predict
357O-linkedHMM predict
384O-linkedHMM predict
388Phosphothreonine(PKA)HMM predict
394Phosphoserine(CDC2)HMM predict
394Phosphoserine(CDK)HMM predict
394O-linkedHMM predict
415MethylarginineHMM predict
421MethylarginineHMM predict
426Phosphoserine(IKK)HMM predict
429Phosphoserine(CDC2)HMM predict
436Phosphoserine(CAMK2)HMM predict
436Phosphoserine(PKG)HMM predict
438Phosphoserine(CK1)HMM predict
467O-linkedHMM predict
470O-linkedHMM predict
471Phosphothreonine(CDK)HMM predict
474Phosphothreonine(MAPK)HMM predict
474Phosphothreonine(CDC2)HMM predict
479Phosphoserine(IKK)HMM predict
479Phosphoserine(CDK)HMM predict
479Phosphoserine(CDC2)HMM predict
486O-linkedHMM predict
490Phosphoserine(PKB)HMM predict
490Phosphoserine(CDC2)HMM predict
492Phosphoserine(MAPK)HMM predict
492O-linkedHMM predict
537O-linkedHMM predict
537O-linkedHMM predict
539O-linkedHMM predict
539Phosphothreonine(MAPK)HMM predict
568Phosphoserine(CK1)HMM predict
569Phosphoserine(CK1)HMM predict
571Phosphoserine(CK1)HMM predict
595Phosphoserine(IKK)HMM predict
599Phosphoserine(CK2)HMM predict
601Phosphoserine(CK1)HMM predict
602Phosphoserine(CK2)HMM predict
602Phosphoserine(CK1)HMM predict
606Phosphoserine(IKK)HMM predict
657Phosphoserine(PKA)HMM predict
657Phosphoserine(PKB)HMM predict
657Phosphoserine(CK2)HMM predict
657Phosphoserine(PKG)HMM predict
672Phosphothreonine(MAPK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_152237
  • Location:chr22 28032996-28038773
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 28032046 28032500 454 724
LIN9 G0GSE7516 28031944 28032639 695 705
LIN9 SGSE7516 28032154 28032729 575 555
Rb QuiescentGSE19898 28032233 28032475 242 643
Rb SenescentGSE19898 28032111 28032457 346 713
Rb SenescentGSE19898 28032503 28033199 696 146
TFAP2C MCF7GSE21234 28031912 28033210 1298 436
hScc1 BcellGSE12603 28030471 28030709 238 2407
hScc1 BcellGSE12603 28031944 28032500 556 775
p130 QuiescentGSE19898 28032195 28032413 218 693
p130 QuiescentGSE19898 28032530 28032706 176 379
p130 SenescentGSE19898 28032132 28032752 620 555
p130 shRbQuiescentGSE19898 28031904 28032523 619 783
p130 shRbSenescentGSE19898 28032031 28033050 1019 456
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 28036793 28037337 544 0
Rb GrowingGSE19898 28036846 28036989 143 0
TFAP2C MCF7GSE21234 28036084 28036851 767 0
p130 SenescentGSE19898 28036951 28037368 417 0
p130 shRbQuiescentGSE19898 28036873 28037474 601 0
p130 shRbSenescentGSE19898 28036976 28037491 515 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-124 hsa-mir-124-1 8 18042700
hsa-miR-124 hsa-mir-124-2 8 18042700
hsa-miR-124 hsa-mir-124-3 20 18042700
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
416 mRNA cleavage TRUE miR-124 GAS2L1 n_a 16549876
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000185340 G1-to-S transition n_a n_a "epithelium, squamous cell, lymphocyte" "malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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