AutismKB 2.0

Annotation Detail for PLK4


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Basic Information Top
Gene Symbol:PLK4 ( SAK,STK18 )
Gene Full Name: polo-like kinase 4
Band: 4q28.1
Quick LinksEntrez ID:10733; OMIM: 605031; Uniprot ID:PLK4_HUMAN; ENSEMBL ID: ENSG00000142731; HGNC ID: 11397
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
377Phosphotyrosine.
378Phosphoserine.
401Phosphoserine.
420Phosphotyrosine.
421Phosphoserine.
499Phosphoserine.
591Phosphothreonine.
592Phosphoserine.
665Phosphoserine.
671Phosphoserine.
817Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
84Phosphotyrosine(INSR)HMM predict
177Phosphotyrosine(INSR)HMM predict
177Phosphotyrosine(EGFR)HMM predict
179Phosphoserine(CDK)HMM predict
255Phosphoserine(CK1)HMM predict
273Phosphoserine(PKA)HMM predict
291O-linkedHMM predict
292O-linkedHMM predict
299O-linkedHMM predict
301Phosphoserine(IKK)HMM predict
301Phosphoserine(CK1)HMM predict
328N-linkedHMM predict
337Phosphoserine(CK2)HMM predict
372Phosphotyrosine(Jak)HMM predict
382Phosphoserine(IKK)HMM predict
382Phosphoserine(CK1)HMM predict
385Phosphoserine(IKK)HMM predict
389Phosphoserine(IKK)HMM predict
389Phosphoserine(ATM)HMM predict
420Phosphotyrosine(SRC)HMM predict
421Phosphoserine(IKK)HMM predict
438Phosphoserine(CK1)HMM predict
439Phosphoserine(CDC2)HMM predict
439Phosphoserine(CK1)HMM predict
443Phosphoserine(IKK)HMM predict
470Phosphothreonine(MAPK)HMM predict
495Phosphotyrosine(INSR)HMM predict
515Phosphoserine(CK1)HMM predict
536Phosphoserine(CK1)HMM predict
568Phosphoserine(CK2)HMM predict
571Phosphoserine(CK1)HMM predict
584N-linkedHMM predict
592Phosphoserine(CDC2)HMM predict
592Phosphoserine(MAPK)HMM predict
632Phosphotyrosine(EGFR)HMM predict
665Phosphoserine(IKK)HMM predict
665Phosphoserine(CDC2)HMM predict
669N-linkedHMM predict
700Phosphoserine(CDC2)HMM predict
751Phosphothreonine(PKC)HMM predict
760Phosphoserine(CK1)HMM predict
787Phosphoserine(CK1)HMM predict
793Phosphothreonine(PKC)HMM predict
809Phosphoserine(IKK)HMM predict
817Phosphoserine(CDC2)HMM predict
817PhosphoserineHMM predict
821Phosphoserine(ATM)HMM predict
868O-linkedHMM predict
870O-linkedHMM predict
929O-linkedHMM predict
947Phosphotyrosine(INSR)HMM predict
958IsoleucineHMM predict
964N-linkedHMM predict
968AsparagineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014264
  • Location:chr4 129021550-129039374
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 129009779 129009819 40 11752
H3K4me3 colorectalcancer 129020832 129021430 598 420
H3ac HepG2E 129020832 129021314 482 478
LIN54 G0GSE7516 129021056 129021943 887 51
Oct1 H2O2-HelaGSE14283 129009784 129009820 36 11749
Oct1 H2O2-HelaGSE14283 129012327 129012357 30 9209
Oct1 HelaGSE14283 129009784 129009822 38 11748
Oct1 HelaGSE14283 129012327 129012357 30 9209
P300 T0-glioblastomaGSE21026 129020851 129021786 935 232
STAT1 HeLaGSE12782 129010825 129012159 1334 10059
STAT1 HeLaGSE12783 129010825 129012051 1226 10113
TFAP2C MCF7GSE21234 129011403 129011802 399 9948
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 129048620 129048655 35 9263
Oct1 H2O2-HelaGSE14283 129049581 129049607 26 10220
Oct1 HelaGSE14283 129048620 129048682 62 9277
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 129021314 129022400 1086 0
E2F4 G0GSE7516 129021123 129022376 1253 0
E2F4 SGSE7516 129021090 129022019 929 0
H3ac HepG2E 129022268 129022615 347 0
LIN9 G0GSE7516 129020905 129022400 1495 0
LIN9 SGSE7516 129020905 129022474 1569 0
Oct1 HelaGSE14283 129027079 129027150 71 0
PHF8 293TGSE20725 129021057 129022389 1332 0
Rb QuiescentGSE19898 129021363 129021767 404 0
TFAP2C MCF7GSE21234 129021264 129022344 1080 0
hScc1 BcellGSE12603 129021242 129021874 632 0
p130 QuiescentGSE19898 129021097 129022408 1311 0
p130 SenescentGSE19898 129021099 129022290 1191 0
p130 shRbQuiescentGSE19898 129020961 129022367 1406 0
p130 shRbSenescentGSE19898 129021264 129022318 1054 0
p130 G0GSE7516 129020981 129022376 1395 0
p130 SGSE7516 129021056 129022225 1169 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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