AutismKB 2.0

Annotation Detail for SIX2


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Basic Information Top
Gene Symbol:SIX2 ( - )
Gene Full Name: SIX homeobox 2
Band: 2p21
Quick LinksEntrez ID:10736; OMIM: 604994; Uniprot ID:SIX2_HUMAN; ENSEMBL ID: ENSG00000170577; HGNC ID: 10888
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
137Phosphoserine(CK1)HMM predict
150Phosphoserine(CDK)HMM predict
150Phosphoserine(CDC2)HMM predict
195Phosphoserine(CK1)HMM predict
202N-linkedHMM predict
211PhosphoserineHMM predict
221Phosphothreonine(MAPK)HMM predict
221Phosphothreonine(CDK)HMM predict
221O-linkedHMM predict
227Phosphoserine(CK1)HMM predict
234Phosphoserine(MAPK)HMM predict
234Phosphoserine(ATM)HMM predict
234Phosphoserine(CDC2)HMM predict
253O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_016932
  • Location:chr2 45085851-45090025
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 45105347 45106250 903 15773
CTCF JurkatGSE12889 45094805 45095049 244 4902
CTCF G2GSE9613 45094075 45095123 1048 4574
CTCF G2GSE9613 45105436 45105786 350 15586
CTCF G2GSE9613 45108768 45108933 165 18825
ER MCF7GSE19013 45090066 45090862 796 439
H3K27me3 colorectalcancer 45091187 45093853 2666 2495
H3K27me3 colorectalcancer 45096145 45096797 652 6446
H3K27me3 colorectalcancer 45097287 45097510 223 7373
P300 T30-glioblastomaGSE21026 45105339 45106286 947 15787
Rb QuiescentGSE19898 45101318 45101419 101 11343
Rb SenescentGSE19898 45090046 45090277 231 136
TFAP2C MCF7GSE21234 45089943 45090987 1044 440
hScc1 G2GSE9613 45105323 45105750 427 15511
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 45080927 45081348 421 4714
CTCF G2GSE9613 45081870 45082225 355 3804
CTCF G2GSE9613 45083552 45083725 173 2213
CTCF G2GSE9613 45084921 45085287 366 748
Fos K562GSE19551 45078672 45078992 320 7020
H3K27me3 colorectalcancer 45071374 45071659 285 14335
H3K27me3 colorectalcancer 45078595 45079579 984 6765
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 45088622 45088927 305 0
CTCF G2GSE9613 45089379 45090574 1195 0
H3K27me3 colorectalcancer 45087369 45089160 1791 0
hScc1 BcellGSE12603 45088892 45090025 1133 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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