AutismKB 2.0

Annotation Detail for MAP3K2


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Basic Information Top
Gene Symbol:MAP3K2 ( MEKK2,MEKK2B )
Gene Full Name: mitogen-activated protein kinase kinase kinase 2
Band: 2q14.3
Quick LinksEntrez ID:10746; OMIM: 609487; Uniprot ID:M3K2_HUMAN; ENSEMBL ID: ENSG00000169967; HGNC ID: 6854
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
26Phosphoserine.
153Phosphoserine.
158Phosphothreonine.
159Phosphoserine.
163Phosphoserine.
164Phosphoserine.
239Phosphoserine.
248Phosphoserine.
293Phosphothreonine.
294Phosphoserine.
297Phosphoserine.
300Phosphoserine.
302Phosphoserine.
304Phosphothreonine (By similarity).
309Phosphoserine.
310Phosphothreonine.
312Phosphoserine.
314Phosphoserine.
315Phosphoserine.
331Phosphoserine.
337Phosphothreonine.
344Phosphoserine.
347Phosphoserine.
349Phosphoserine.
514Phosphoserine.
524Phosphothreonine (By similarity).
Location(AA) Modifications Resource
164Phosphoserine.Swiss-Prot 53.0
304Phosphothreonine (By similarity).Swiss-Prot 53.0
331Phosphoserine (By similarity).Swiss-Prot 53.0
524Phosphothreonine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
37Phosphoserine(CDK)HMM predict
37PhosphoserineHMM predict
37Phosphoserine(CDC2)HMM predict
84SulfotyrosineHMM predict
122N-linkedHMM predict
163O-linkedHMM predict
163Phosphoserine(IKK)HMM predict
164O-linkedHMM predict
180N-linkedHMM predict
205Phosphoserine(IKK)HMM predict
207Phosphoserine(CK1)HMM predict
208Phosphoserine(CDC2)HMM predict
212Phosphoserine(CK1)HMM predict
214O-linkedHMM predict
216Phosphoserine(IKK)HMM predict
219Phosphoserine(IKK)HMM predict
239Phosphoserine(PKB)HMM predict
248Phosphoserine(CK1)HMM predict
250Phosphotyrosine(INSR)HMM predict
250Phosphotyrosine(Syk)HMM predict
250SulfotyrosineHMM predict
263Phosphothreonine(PKC)HMM predict
277SulfotyrosineHMM predict
290Phosphothreonine(PKA)HMM predict
300Phosphoserine(IKK)HMM predict
302Phosphoserine(CDC2)HMM predict
307Phosphoserine(IKK)HMM predict
309Phosphoserine(CK1)HMM predict
309O-linkedHMM predict
310O-linkedHMM predict
312Phosphoserine(CK1)HMM predict
315O-linkedHMM predict
331Phosphoserine(PKB)HMM predict
335N-linkedHMM predict
349Phosphoserine(CDC2)HMM predict
371Phosphotyrosine(Jak)HMM predict
393Phosphoserine(IKK)HMM predict
397Phosphoserine(CK1)HMM predict
458N-linkedHMM predict
538Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006609
  • Location:chr2 127778608-127817239
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 127829519 127829721 202 12381
CTCF CD4SISSRdata 127829519 127829721 202 12381
Gata2 K562GSE18868 127829386 127829907 521 12407
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog hESGSE18292 127798874 127799145 271 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-26a hsa-mir-26a-1 3 20080666
hsa-miR-26a hsa-mir-26a-2 12 20080666
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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