AutismKB 2.0

Annotation Detail for TOB2


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Basic Information Top
Gene Symbol:TOB2 ( TOB4,TOBL,TROB2 )
Gene Full Name: transducer of ERBB2, 2
Band: 22q13.2
Quick LinksEntrez ID:10766; OMIM: 607396; Uniprot ID:TOB2_HUMAN; ENSEMBL ID: ENSG00000183864; HGNC ID: 11980
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
254Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
148Phosphoserine(IKK)HMM predict
149Phosphoserine(IKK)HMM predict
151Phosphoserine(CK2)HMM predict
153Phosphoserine(IKK)HMM predict
153Phosphoserine(ATM)HMM predict
153Phosphoserine(CDK)HMM predict
153PhosphoserineHMM predict
153Phosphoserine(CDC2)HMM predict
155Phosphoserine(CDC2)HMM predict
155O-linkedHMM predict
161Phosphoserine(CDC2)HMM predict
163Phosphoserine(CDC2)HMM predict
178O-linkedHMM predict
206O-linkedHMM predict
222Phosphoserine(CDC2)HMM predict
234Phosphoserine(CK1)HMM predict
251Phosphoserine(IKK)HMM predict
280O-linkedHMM predict
282Phosphothreonine(MAPK)HMM predict
295N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_016272
  • Location:chr22 40159437-40172972
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 40173596 40173776 180 714
ETS1 JurkatGSE17954 40172533 40173598 1065 93
ETS1 JurkatGSE17954 40173672 40175500 1828 1614
FOXA1 MCF7GSE15244 40174074 40175024 950 1577
Fos K562GSE19551 40174282 40174945 663 1641
H3ac HepG2E 40173947 40175286 1339 1644
NFkBII GM10847GSE19485 40171858 40175060 3202 487
NFkBII GM18526GSE19485 40172204 40175243 3039 751
PHF8 HeLaGSE20725 40172105 40174758 2653 459
Pol2 GM12878GSE19551 40172376 40174834 2458 633
RARG MCF7GSE15244 40174654 40175132 478 1921
Rb SenescentGSE19898 40174160 40174752 592 1484
TFAP2C MCF7GSE21234 40173242 40173773 531 535
TFAP2C MCF7GSE21234 40173858 40174920 1062 1417
VDR GM10861-stimGSE22484 40172191 40175783 3592 1015
p130 shRbQuiescentGSE19898 40173856 40174783 927 1347
p130 shRbSenescentGSE19898 40173846 40174543 697 1222
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Rb GrowingGSE19898 40157878 40158059 181 1469
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 40169979 40170894 915 0
H3K4me3 colorectalcancer 40170619 40172184 1565 0
H3ac HepG2E 40168922 40169244 322 0
H3ac HepG2E 40169918 40172317 2399 0
hScc1 BcellGSE12603 40172734 40173161 427 0
p130 QuiescentGSE19898 40172563 40173076 513 0
p130 SenescentGSE19898 40172480 40173087 607 0
p130 shRbSenescentGSE19898 40172554 40173127 573 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-378 hsa-mir-378 5 21242960
hsa-miR-378* hsa-mir-378 5 21242960
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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