Annotation Detail for NEK6
Basic Information Top
| Gene Symbol: | NEK6 ( SID6-1512 ) |
|---|---|
| Gene Full Name: | NIMA (never in mitosis gene a)-related kinase 6 |
| Band: | 9q33.3 |
| Quick Links | Entrez ID:10783; OMIM: 604884; Uniprot ID:NEK6_HUMAN; ENSEMBL ID: ENSG00000119408; HGNC ID: 7749 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 35 | Phosphothreonine. | |
| 198 | Phosphoserine. | |
| 199 | Phosphoserine. | |
| 201 | Phosphothreonine. | |
| 202 | Phosphothreonine. | |
| 206 | Phosphoserine. | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 202 | Phosphothreonine | Phospho.ELM 6.0 |
| 206 | Phosphoserine (NEK9) | Phospho.ELM 6.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 131 | Phosphoserine(ATM) | HMM predict |
| 206 | Phosphoserine(IKK) | HMM predict |
| 213 | Phosphotyrosine(INSR) | HMM predict |
| 213 | Phosphotyrosine(SRC) | HMM predict |
| 215 | Phosphoserine(CDC2) | HMM predict |
| 266 | Phosphotyrosine(Syk) | HMM predict |
| 266 | Sulfotyrosine | HMM predict |
| 298 | Phosphotyrosine(Jak) | HMM predict |
- RefSeq ID: NM_014397
- Location:chr9 126060069-126154537
- strand:+
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| NFkBII | GM12878 | GSE19485 | 126040662 | 126042869 | 2207 | 18304 |
| NFkBII | GM12878 | GSE19485 | 126055888 | 126057308 | 1420 | 3472 |
| hScc1 | Bcell | GSE12603 | 126059742 | 126060382 | 640 | 8 |
| p130 | Senescent | GSE19898 | 126044787 | 126044997 | 210 | 15178 |
| p130 | Senescent | GSE19898 | 126045040 | 126045231 | 191 | 14934 |
| p130 | Senescent | GSE19898 | 126054261 | 126054444 | 183 | 5717 |
| p130 | shRbQuiescent | GSE19898 | 126044755 | 126045357 | 602 | 15014 |
| No data |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CBP | T0-glioblastoma | GSE21026 | 126099337 | 126100085 | 748 | 0 |
| CBP | T30-glioblastoma | GSE21026 | 126111479 | 126112429 | 950 | 0 |
| CTCF | CD4 | GSE12889 | 126122484 | 126122717 | 233 | 0 |
| CTCF | CD4 | SISSRdata | 126122484 | 126122717 | 233 | 0 |
| CTCF | Jurkat | GSE12889 | 126114444 | 126114616 | 172 | 0 |
| FOXA1 | MCF7 | GSE15244 | 126061141 | 126062134 | 993 | 0 |
| Fos | K562 | GSE19551 | 126108400 | 126108825 | 425 | 0 |
| H3ac | HepG2 | E | 126060486 | 126062134 | 1648 | 0 |
| H3ac | HepG2 | E | 126063217 | 126064364 | 1147 | 0 |
| HIF1 | Hypo | HepG2 | 126086471 | 126087048 | 577 | 0 |
| Myc | hES | GSE17917 | 126095859 | 126096098 | 239 | 0 |
| NFkBII | GM12878 | GSE19485 | 126092263 | 126096458 | 4195 | 0 |
| NFkBII | GM12892 | GSE19485 | 126093577 | 126095390 | 1813 | 0 |
| P300 | T0-glioblastoma | GSE21026 | 126099210 | 126100182 | 972 | 0 |
| P300 | T0-glioblastoma | GSE21026 | 126111633 | 126112100 | 467 | 0 |
| P300 | T30-glioblastoma | GSE21026 | 126087625 | 126089247 | 1622 | 0 |
| P300 | T30-glioblastoma | GSE21026 | 126099164 | 126100410 | 1246 | 0 |
| P300 | T30-glioblastoma | GSE21026 | 126111270 | 126112469 | 1199 | 0 |
| Rb | Growing | GSE19898 | 126099787 | 126099964 | 177 | 0 |
| TFAP2C | MCF7 | GSE21234 | 126060838 | 126062074 | 1236 | 0 |
| TFAP2C | MCF7 | GSE21234 | 126144882 | 126145779 | 897 | 0 |
| hScc1 | Bcell | GSE12603 | 126084765 | 126085088 | 323 | 0 |
| hScc1 | Bcell | GSE12603 | 126088339 | 126088675 | 336 | 0 |
| hScc1 | Bcell | GSE12603 | 126097234 | 126098304 | 1070 | 0 |
| hScc1 | Bcell | GSE12603 | 126113279 | 126113513 | 234 | 0 |
| hScc1 | Bcell | GSE12603 | 126122356 | 126123053 | 697 | 0 |
| hScc1 | Bcell | GSE12603 | 126148152 | 126148501 | 349 | 0 |
| hScc1 | CdLS | GSE12603 | 126122203 | 126122742 | 539 | 0 |
| hScc1 | G2 | GSE9613 | 126122167 | 126122742 | 575 | 0 |
| p130 | shRbQuiescent | GSE19898 | 126108373 | 126108885 | 512 | 0 |
| p63 | keratinocytes | GSE17611 | 126104754 | 126105892 | 1138 | 0 |
| Micro RNA Name | Stem Loop Name | The chromosome that miRNA located | Publication |
|---|---|---|---|
| hsa-miR-1 | hsa-mir-1-2 | 18 | 15685193 |
| hsa-miR-1 | hsa-mir-1-1 | 20 | 15685193 |
| hsa-miR-124 | hsa-mir-124-1 | 8 | 15685193 |
| hsa-miR-124 | hsa-mir-124-2 | 8 | 15685193 |
| hsa-miR-124 | hsa-mir-124-3 | 20 | 15685193 |
| hsa-miR-373 | hsa-mir-373 | 19 | 15685193 |
| hsa-miR-373* | hsa-mir-373 | 19 | 15685193 |
| ID in Tarbase | Data Type | Support Type | miRNA | Gene | Direct Support | Publication |
|---|---|---|---|---|---|---|
| 339 | Unknown | MicroArray | miR-124 | NEK6 | n_a | 15685193 |
| Ensembl | Protein Type | Differentially expressed in | Pathology or Event | Mis Regulation | Gene Expression | Tumour Involvement |
| ENSG00000119408 | G1-to-S transition | n_a | n_a | "epithelium, squamous cell, lymphocyte, leukocyte, macrophage, muscle cell" | "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma" |
Cis-Nats regulation