AutismKB 2.0

Annotation Detail for PPARGC1A


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Basic Information Top
Gene Symbol:PPARGC1A ( LEM6,PGC-1(alpha),PGC-1v,PGC1,PGC1A,PPARGC1 )
Gene Full Name: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Band: 4p15.2
Quick LinksEntrez ID:10891; OMIM: 604517; Uniprot ID:PRGC1_HUMAN; ENSEMBL ID: ENSG00000109819; HGNC ID: 9237
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
148LXXLL motif.
Location(AA) Modifications Resource
263Phosphothreonine (MAPK14;p38
266Phosphoserine (MAPK14;p38
299Phosphothreonine (MAPK14;p38
Location(AA) Modification Resource
39Phosphoserine(CK1)HMM predict
119Phosphothreonine(CK2)HMM predict
126O-linkedHMM predict
132O-linkedHMM predict
230N-linkedHMM predict
246Phosphoserine(ATM)HMM predict
263Phosphothreonine(CDC2)HMM predict
263Phosphothreonine(CDK)HMM predict
263Phosphothreonine(MAPK)HMM predict
273Phosphoserine(CDC2)HMM predict
277N-linkedHMM predict
285Phosphoserine(IKK)HMM predict
285Phosphoserine(CK1)HMM predict
295Phosphothreonine(MAPK)HMM predict
295Phosphothreonine(CDK)HMM predict
295O-linkedHMM predict
299Phosphothreonine(MAPK)HMM predict
299Phosphothreonine(CDK)HMM predict
334Phosphoserine(CK1)HMM predict
334O-linkedHMM predict
343N-linkedHMM predict
355Phosphotyrosine(Jak)HMM predict
373Phosphothreonine(PKC)HMM predict
392Phosphoserine(CK1)HMM predict
427O-linkedHMM predict
445Phosphoserine(IKK)HMM predict
470Phosphoserine(ATM)HMM predict
514Phosphoserine(CK2)HMM predict
535N-linkedHMM predict
542Phosphoserine(IKK)HMM predict
545Phosphoserine(IKK)HMM predict
552Phosphoserine(ATM)HMM predict
552Phosphoserine(IKK)HMM predict
552Phosphoserine(CDC2)HMM predict
573Phosphoserine(CK1)HMM predict
577Phosphoserine(PKB)HMM predict
581Phosphoserine(CDC2)HMM predict
588Phosphoserine(PKG)HMM predict
588PhosphoserineHMM predict
590Phosphoserine(IKK)HMM predict
590Phosphoserine(CDC2)HMM predict
590Phosphoserine(CDK)HMM predict
602Phosphotyrosine(Syk)HMM predict
626Phosphoserine(CDC2)HMM predict
637SulfotyrosineHMM predict
650Phosphotyrosine(INSR)HMM predict
654Phosphotyrosine(Syk)HMM predict
659Phosphoserine(CK2)HMM predict
691Phosphothreonine(CDK)HMM predict
741Phosphoserine(PKG)HMM predict
742N-linkedHMM predict
766Phosphoserine(CK2)HMM predict
776Phosphothreonine(PKC)HMM predict
780Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_013261
  • Location:chr4 23402742-23500797
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct4 hESGSE17917 23517049 23517199 150 16327
USF1 HepG2E 23500192 23501856 1664 227
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 23389756 23389965 209 12882
CTCF G2GSE9613 23386235 23386682 447 16284
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 23422448 23422661 213 0
CTCF G2GSE9613 23500624 23500869 245 0
ER Fulvestrant-MCF7GSE14664 23418207 23418240 33 0
H3K4me3 colorectalcancer 23499118 23499979 861 0
H3ac HepG2E 23489906 23490921 1015 0
H3ac HepG2E 23491421 23491888 467 0
H3ac HepG2E 23498642 23499979 1337 0
Nanog hESGSE18292 23407837 23408094 257 0
Oct1 H2O2-HelaGSE14283 23418207 23418241 34 0
Oct1 HelaGSE14283 23418207 23418243 36 0
Oct1 HelaGSE14283 23484912 23484945 33 0
Oct4 hESGSE21916 23496773 23497335 562 0
P300 T0-glioblastomaGSE21026 23422169 23423021 852 0
P300 T30-glioblastomaGSE21026 23466333 23467472 1139 0
RNAII Tamoxifen-MCF7GSE14664 23418201 23418240 39 0
Rb GrowingGSE19898 23499848 23500022 174 0
USF1 HepG2E 23499118 23499900 782 0
USF2 HepG2E 23491519 23492101 582 0
USF2 HepG2E 23499191 23499712 521 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-122 hsa-mir-122 18 21241755
hsa-miR-122* hsa-mir-122 18 21241755
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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