AutismKB 2.0

Annotation Detail for YWHAQ


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Basic Information Top
Gene Symbol:YWHAQ ( 14-3-3,1C5,HS1 )
Gene Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Band: 2p25.1
Quick LinksEntrez ID:10971; OMIM: 609009; Uniprot ID:1433T_HUMAN; ENSEMBL ID: ENSG00000134308; HGNC ID: 12854
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
3N6-acetyllysine.
49N6-acetyllysine.
68N6-acetyllysine.
115N6-acetyllysine.
232Phosphoserine.
Location(AA) Modifications Resource
232Phosphoserine (CK1
Location(AA) Modification Resource
19SulfotyrosineHMM predict
19Phosphotyrosine(Syk)HMM predict
71Phosphothreonine(CK2)HMM predict
88Phosphoserine(CK1)HMM predict
92Phosphoserine(IKK)HMM predict
108N-linkedHMM predict
111N-linkedHMM predict
141Phosphothreonine(PKC)HMM predict
173N-linkedHMM predict
211Phosphotyrosine(EGFR)HMM predict
224N-linkedHMM predict
237S-farnesylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006826
  • Location:chr2 9641557-9688556
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 9695112 9695316 204 6658
CTCF G2GSE9613 9703775 9704000 225 15331
ER Fulvestrant-MCF7GSE14664 9695291 9695330 39 6754
ER Fulvestrant-MCF7GSE14664 9696440 9696474 34 7901
FOXA1 MCF7GSE15244 9693675 9694549 874 5556
FOXA1 MCF7GSE15244 9701476 9702890 1414 13627
Fos K562GSE19551 9688300 9689176 876 182
Oct1 H2O2-HelaGSE14283 9695364 9695411 47 6831
Oct1 HelaGSE14283 9695546 9695580 34 7007
Oct1 HelaGSE14283 9696446 9696487 41 7910
P300 T0-glioblastomaGSE21026 9696000 9696868 868 7878
TFAP2C MCF7GSE21234 9696070 9696474 404 7716
VDR GM10855-stimGSE22484 9698688 9700885 2197 11230
VDR GM10861-stimGSE22484 9698732 9701110 2378 11365
hScc1 BcellGSE12603 9706431 9706616 185 17967
p130 shRbSenescentGSE19898 9688142 9689112 970 71
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 9641496 9641529 33 45
Oct1 H2O2-HelaGSE14283 9630157 9630196 39 11381
Oct1 HelaGSE14283 9630157 9630203 46 11378
Oct1 HelaGSE14283 9641495 9641527 32 47
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 9687725 9688844 1119 0
FOXA1 MCF7GSE15244 9665816 9666219 403 0
Fos K562GSE19551 9665428 9666220 792 0
FoxA1 MCF7MACSdata 9666060 9666269 209 0
H3K4me3 colorectalcancer 9686912 9687725 813 0
H3ac HepG2E 9685425 9687908 2483 0
P300 T0-glioblastomaGSE21026 9670577 9671592 1015 0
P300 T30-glioblastomaGSE21026 9670790 9671455 665 0
PHF8 HeLaGSE20725 9687574 9689118 1544 0
PHF8 Hs68plusFBSGSE20725 9687533 9689094 1561 0
STAT1 HeLaGSE12783 9652120 9653434 1314 0
Stat6 IL-4-hr1GSE17850 9665452 9665950 498 0
TAF k562GSE8489 9666560 9666851 291 0
Validated miRNA targets Top
No data
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1213 Unknown pSILAC miR-1 YWHAQ down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000134308 n_a n_a n_a "epithelium, squamous cell, lymphoblast, leukocyte, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, non-Hodgkin's, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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