AutismKB 2.0

Annotation Detail for METAP2


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Basic Information Top
Gene Symbol:METAP2 ( MAP2,MNPEP,p67,p67eIF2 )
Gene Full Name: methionyl aminopeptidase 2
Band: 12q22
Quick LinksEntrez ID:10988; OMIM: 601870; Uniprot ID:AMPM2_HUMAN; ENSEMBL ID: ENSG00000111142; HGNC ID: 16672
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
45Phosphoserine.
60Phosphoserine.
63Phosphoserine.
74Phosphoserine.
427N6-acetyllysine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
29Phosphoserine(PKG)HMM predict
29Phosphoserine(CK2)HMM predict
30Phosphothreonine(CK2)HMM predict
137SulfotyrosineHMM predict
150Phosphothreonine(PKC)HMM predict
343Phosphothreonine(PKC)HMM predict
361Phosphotyrosine(Abl)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006838
  • Location:chr12 94391952-94433741
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 94391806 94392082 276 9
ETS1 JurkatGSE17954 94391063 94392478 1415 182
FOXA1 DLD1GSE12801 94388215 94388787 572 3452
FOXA1 MCF7GSE15244 94388215 94388714 499 3488
GATA3 MCF7GSE15244 94385448 94385779 331 6339
GATA3 MCF7GSE15244 94388215 94388421 206 3635
H3K4me3 colorectalcancer 94391168 94391670 502 534
H3ac HepG2E 94391133 94391806 673 483
Oct1 HelaGSE14283 94379829 94379856 27 12110
PolII HeLaGSE12783 94390795 94393104 2309 3
RARA MCF7GSE15244 94391056 94391670 614 590
RARG MCF7GSE15244 94385180 94385779 599 6473
RARG MCF7GSE15244 94391244 94391873 629 394
TAF HelaGSE8489 94390880 94391835 955 595
hScc1 BcellGSE12603 94385180 94385377 197 6674
hScc1 CdLSGSE12603 94391520 94392051 531 167
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 94391244 94392797 1553 0
H3K4me3 colorectalcancer 94392197 94393303 1106 0
H3ac HepG2E 94392051 94394071 2020 0
Oct1 H2O2-HelaGSE14283 94400652 94400679 27 0
Oct1 H2O2-HelaGSE14283 94412941 94412971 30 0
Oct1 H2O2-HelaGSE14283 94421055 94421084 29 0
Oct1 HelaGSE14283 94421053 94421082 29 0
PHF8 293TGSE20725 94391563 94392680 1117 0
PHF8 HeLaGSE20725 94391485 94392644 1159 0
Pol2 GM12878GSE19551 94391679 94392711 1032 0
RARG MCF7GSE15244 94392370 94392797 427 0
Rb QuiescentGSE19898 94392379 94392702 323 0
TAF HelaGSE8489 94392155 94393896 1741 0
TAF k562GSE8489 94390984 94394106 3122 0
TAFII hESGSE17917 94391762 94392359 597 0
p130 SenescentGSE19898 94392468 94392656 188 0
p130 shRbQuiescentGSE19898 94391782 94392590 808 0
p130 shRbSenescentGSE19898 94391918 94392164 246 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-26a hsa-mir-26a-1 3 17592044
hsa-miR-26a hsa-mir-26a-2 12 17592044
hsa-miR-26a hsa-mir-26a-1 3 17592044
hsa-miR-26a hsa-mir-26a-2 12 17592044
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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