AutismKB 2.0

Annotation Detail for TLK2


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Basic Information Top
Gene Symbol:TLK2 ( MGC44450,PKU-ALPHA )
Gene Full Name: tousled-like kinase 2
Band: 17q23
Quick LinksEntrez ID:11011; OMIM: 608439; Uniprot ID:TLK2_HUMAN; ENSEMBL ID: ENSG00000146872; HGNC ID: 11842
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
32Phosphoserine.
70Phosphotyrosine.
72Phosphothreonine.
73Phosphoserine.
94Phosphoserine.
98Phosphothreonine.
99Phosphoserine.
110Phosphoserine.
111Phosphoserine.
115Phosphoserine.
117Phosphoserine.
134Phosphoserine.
196Phosphoserine.
300Phosphothreonine.
750Phosphoserine (By similarity).
753Phosphoserine.
769Phosphoserine.
770Phosphoserine.
771Phosphoserine.
Location(AA) Modifications Resource
99Phosphoserine.Swiss-Prot 53.0
99PhosphoserinePhospho.ELM 6.0
750Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
36N-linkedHMM predict
38Phosphoserine(PKA)HMM predict
38Phosphoserine(IKK)HMM predict
52Phosphothreonine(CDK)HMM predict
52Phosphothreonine(CDC2)HMM predict
94O-linkedHMM predict
99Phosphoserine(CDC2)HMM predict
99O-linkedHMM predict
99PhosphoserineHMM predict
103O-linkedHMM predict
148Phosphothreonine(PKC)HMM predict
182Phosphoserine(CDC2)HMM predict
182Phosphoserine(IKK)HMM predict
184Phosphoserine(CK1)HMM predict
185O-linkedHMM predict
186O-linkedHMM predict
194Phosphoserine(IKK)HMM predict
197Phosphoserine(CK1)HMM predict
197Phosphoserine(ATM)HMM predict
208Phosphothreonine(PKA)HMM predict
268Phosphothreonine(PKC)HMM predict
365Phosphoserine(PKG)HMM predict
372N-linkedHMM predict
377Phosphoserine(CK2)HMM predict
477Phosphotyrosine(Syk)HMM predict
487Phosphotyrosine(Jak)HMM predict
487Phosphotyrosine(SRC)HMM predict
539Phosphoserine(IKK)HMM predict
602N-linkedHMM predict
625Phosphotyrosine(Syk)HMM predict
635Phosphoserine(ATM)HMM predict
684N-linkedHMM predict
686Phosphoserine(ATM)HMM predict
711Phosphothreonine(MAPK)HMM predict
750Phosphoserine(IKK)HMM predict
753Phosphoserine(CDC2)HMM predict
761O-linkedHMM predict
763Phosphoserine(IKK)HMM predict
766O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006852
  • Location:chr17 57910135-58044756
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 57909387 57910291 904 297
Fos K562GSE19551 57901871 57902242 371 8079
H3ac HepG2E 57903857 57904555 698 5930
Jun K562GSE19551 57901811 57902178 367 8141
Myc K562GSE19551 57901823 57902197 374 8126
Myc K562GSE19551 57909563 57909762 199 473
PHF8 Hs68minusFBSGSE20725 57909233 57909781 548 629
PolII HeLaGSE12783 57908637 57911223 2586 206
RARA MCF7GSE15244 57902062 57902608 546 7801
RARA MCF7GSE15244 57908383 57908910 527 1489
RARG MCF7GSE15244 57902062 57902956 894 7627
hScc1 BcellGSE12603 57909082 57910073 991 558
hScc1 CdLSGSE12603 57909156 57910416 1260 350
p63 keratinocytesGSE17611 57901638 57902374 736 8130
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
p130 SenescentGSE19898 58048567 58048840 273 3947
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 57916216 57916418 202 0
CTCF CD4GSE12889 57984343 57984547 204 0
CTCF CD4SISSRdata 57916216 57916418 202 0
CTCF CD4SISSRdata 57984343 57984547 204 0
CTCF G2GSE9613 57916150 57916371 221 0
CTCF G2GSE9613 57984200 57984780 580 0
H3K4me3 colorectalcancer 57911124 57911692 568 0
H3ac HepG2E 57910680 57913013 2333 0
RARA MCF7GSE15244 57984123 57984672 549 0
RARG MCF7GSE15244 57971807 57972470 663 0
RARG MCF7GSE15244 57984236 57984589 353 0
TAF HelaGSE8489 57911015 57912105 1090 0
TAF k562GSE8489 57910906 57913013 2107 0
TAF k562GSE8489 57913961 57914553 592 0
USF2 HepG2E 57971807 57972470 663 0
hScc1 BcellGSE12603 57916150 57916452 302 0
hScc1 BcellGSE12603 57984200 57984625 425 0
hScc1 CdLSGSE12603 57916150 57916407 257 0
hScc1 CdLSGSE12603 57984123 57984780 657 0
hScc1 G2GSE9613 57984200 57984780 580 0
p63 keratinocytesGSE17611 57941329 57941976 647 0
p63 keratinocytesGSE17611 57984399 57985072 673 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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