AutismKB 2.0

Annotation Detail for CHD1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CHD1 ( DKFZp686E2337 )
Gene Full Name: chromodomain helicase DNA binding protein 1
Band: 5q15-q21.1
Quick LinksEntrez ID:1105; OMIM: 602118; Uniprot ID:CHD1_HUMAN; ENSEMBL ID: ENSG00000153922; HGNC ID: 1915
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
5Phosphoserine (By similarity).
89Phosphoserine.
90Phosphoserine.
92Phosphoserine.
215Phosphoserine.
216Phosphoserine.
237Phosphothreonine.
241Phosphoserine.
250Phosphothreonine.
252Phosphoserine.
617DEAH box.
1040Phosphoserine.
1068Phosphotyrosine.
1081Phosphoserine.
1096Phosphoserine.
1098Phosphoserine.
1100Phosphoserine.
1102Phosphoserine.
1328Phosphoserine.
1353Phosphoserine.
1355Phosphoserine.
1356Phosphoserine.
1360Phosphoserine.
1387Phosphoserine.
1396Phosphoserine.
1403Phosphoserine.
1406Phosphoserine.
1622Phosphoserine.
1677Phosphoserine.
1689Phosphoserine.
1700Phosphothreonine.
Location(AA) Modifications Resource
5Phosphoserine (By similarity).Swiss-Prot 53.0
215PhosphoserinePhospho.ELM 6.0
216PhosphoserinePhospho.ELM 6.0
1068Phosphotyrosine.Swiss-Prot 53.0
1068PhosphotyrosinePhospho.ELM 6.0
1353Phosphoserine.Swiss-Prot 53.0
1355Phosphoserine.Swiss-Prot 53.0
1356Phosphoserine.Swiss-Prot 53.0
1360Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
9Phosphoserine(CK1)HMM predict
12N-linkedHMM predict
13Phosphoserine(PKG)HMM predict
14Phosphoserine(CK2)HMM predict
18Phosphoserine(CK2)HMM predict
18Phosphoserine(ATM)HMM predict
20Phosphoserine(ATM)HMM predict
24Phosphoserine(CK1)HMM predict
24Phosphoserine(IKK)HMM predict
26Phosphoserine(CK1)HMM predict
28Phosphoserine(IKK)HMM predict
30Phosphoserine(IKK)HMM predict
32Phosphoserine(IKK)HMM predict
34Phosphoserine(CDC2)HMM predict
34Phosphoserine(IKK)HMM predict
38Phosphoserine(CK1)HMM predict
40Phosphoserine(ATM)HMM predict
43O-linkedHMM predict
43Phosphoserine(CK1)HMM predict
43Phosphoserine(IKK)HMM predict
45Phosphoserine(ATM)HMM predict
47Phosphoserine(CK2)HMM predict
47Phosphoserine(IKK)HMM predict
49Phosphoserine(IKK)HMM predict
54Phosphoserine(CK1)HMM predict
54Phosphoserine(ATM)HMM predict
54Phosphoserine(IKK)HMM predict
56Phosphoserine(CK1)HMM predict
56Phosphoserine(IKK)HMM predict
58Phosphoserine(IKK)HMM predict
60Phosphoserine(CK1)HMM predict
60Phosphoserine(ATM)HMM predict
60Phosphoserine(IKK)HMM predict
62Phosphoserine(CK2)HMM predict
62Phosphoserine(IKK)HMM predict
64Phosphoserine(IKK)HMM predict
68Phosphothreonine(CK2)HMM predict
90Phosphoserine(CDC2)HMM predict
120Phosphoserine(CK1)HMM predict
120Phosphoserine(CK2)HMM predict
122Phosphoserine(CK1)HMM predict
122Phosphoserine(CK2)HMM predict
127Phosphoserine(CK1)HMM predict
128Phosphoserine(CK1)HMM predict
129Phosphoserine(CK2)HMM predict
135Phosphoserine(CK1)HMM predict
136Phosphoserine(CK1)HMM predict
154Phosphoserine(ATM)HMM predict
156Phosphoserine(CDC2)HMM predict
156Phosphoserine(IKK)HMM predict
156PhosphoserineHMM predict
158Phosphoserine(ATM)HMM predict
158Phosphoserine(IKK)HMM predict
164Phosphoserine(CK2)HMM predict
166Phosphoserine(CK1)HMM predict
166Phosphoserine(CK2)HMM predict
173Phosphoserine(IKK)HMM predict
173Phosphoserine(PKB)HMM predict
174Phosphoserine(IKK)HMM predict
180Phosphoserine(CK1)HMM predict
182Phosphotyrosine(INSR)HMM predict
195N-linkedHMM predict
201N-linkedHMM predict
215Phosphoserine(CK2)HMM predict
216Phosphoserine(CK2)HMM predict
225Phosphotyrosine(INSR)HMM predict
225Phosphotyrosine(Syk)HMM predict
225SulfotyrosineHMM predict
250Phosphothreonine(CK2)HMM predict
285O-linkedHMM predict
288O-linkedHMM predict
291O-linkedHMM predict
293O-linkedHMM predict
359Phosphothreonine(PKC)HMM predict
365N-linkedHMM predict
373Phosphotyrosine(Jak)HMM predict
373SulfotyrosineHMM predict
374Phosphotyrosine(Jak)HMM predict
381Phosphothreonine(CK2)HMM predict
444N-linkedHMM predict
446Phosphoserine(PKG)HMM predict
446Phosphoserine(CAMK2)HMM predict
446Phosphoserine(IKK)HMM predict
449Phosphothreonine(CDK)HMM predict
759S-palmitoylHMM predict
952O-linkedHMM predict
952O-linkedHMM predict
955Phosphoserine(CDK)HMM predict
956O-linkedHMM predict
958Phosphothreonine(CDC2)HMM predict
958Phosphothreonine(CDK)HMM predict
1023N-linkedHMM predict
1026N-linkedHMM predict
1040Phosphoserine(CK1)HMM predict
1068Phosphotyrosine(INSR)HMM predict
1068Phosphotyrosine(SRC)HMM predict
1083N-linkedHMM predict
1096Phosphoserine(PKG)HMM predict
1096Phosphoserine(CAMK2)HMM predict
1096Phosphoserine(CK1)HMM predict
1096Phosphoserine(IKK)HMM predict
1098Phosphoserine(ATM)HMM predict
1100Phosphoserine(ATM)HMM predict
1102Phosphoserine(CK1)HMM predict
1102Phosphoserine(IKK)HMM predict
1117Phosphothreonine(PKC)HMM predict
1185Phosphoserine(CK1)HMM predict
1230Phosphoserine(CK2)HMM predict
1239PhosphothreonineHMM predict
1324Phosphoserine(CK2)HMM predict
1328Phosphoserine(CDC2)HMM predict
1329Phosphoserine(PKC)HMM predict
1356Phosphoserine(ATM)HMM predict
1356Phosphoserine(IKK)HMM predict
1363Phosphoserine(CK1)HMM predict
1371Phosphoserine(CK1)HMM predict
1387O-linkedHMM predict
1396O-linkedHMM predict
1403Phosphoserine(CK2)HMM predict
1406Phosphoserine(CK2)HMM predict
1465Phosphotyrosine(INSR)HMM predict
1466Phosphothreonine(INSR)HMM predict
1507Phosphoserine(PKA)HMM predict
1507Phosphoserine(PKG)HMM predict
1507Phosphoserine(IKK)HMM predict
1515Phosphoserine(IKK)HMM predict
1540Phosphoserine(CK1)HMM predict
1545Phosphoserine(CK1)HMM predict
1578Phosphoserine(CDK)HMM predict
1598Phosphotyrosine(Syk)HMM predict
1629Phosphoserine(CK1)HMM predict
1635Phosphoserine(CK1)HMM predict
1641Phosphoserine(CK1)HMM predict
1645Phosphoserine(CK1)HMM predict
1645Phosphoserine(CK2)HMM predict
1647Phosphoserine(CK1)HMM predict
1677Phosphoserine(CDC2)HMM predict
1677Phosphoserine(IKK)HMM predict
1699Phosphothreonine(PKA)HMM predict
1699Phosphothreonine(MAPK)HMM predict
1699Phosphothreonine(CDK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001270
  • Location:chr5 98218808-98290137
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 98291644 98292376 732 1873
CTCF G2GSE9613 98292873 98293209 336 2904
H3K4me3 colorectalcancer 98290822 98291492 670 1020
H3ac HepG2E 98290651 98291718 1067 1047
H3ac HepG2E 98292873 98293639 766 3119
HIF1 NormHepG2 98292246 98293105 859 2538
NRSF mAbJurkat 98290730 98291608 878 1032
P300 T30-glioblastomaGSE21026 98298644 98299312 668 8841
PHF8 HeLaGSE20725 98291294 98293552 2258 2286
PHF8 Hs68minusFBSGSE20725 98292218 98293411 1193 2677
Rb GrowingGSE19898 98291553 98291728 175 1503
Rb GrowingGSE19898 98302458 98302646 188 12415
TAF HelaGSE8489 98290917 98291572 655 1107
hScc1 BcellGSE12603 98291572 98292220 648 1759
p130 SenescentGSE19898 98293126 98293529 403 3190
p130 shRbQuiescentGSE19898 98292774 98293355 581 2927
p130 shRbSenescentGSE19898 98292419 98293287 868 2716
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 98203482 98203643 161 15246
CTCF CD4SISSRdata 98203482 98203643 161 15246
ER E2-MCF7GSE14664 98200916 98200948 32 17877
Oct1 H2O2-HelaGSE14283 98217027 98217105 78 1743
Oct1 HelaGSE14283 98217030 98217105 75 1741
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 98252479 98252510 31 0
TFAP2C MCF7GSE21234 98270491 98270939 448 0
hScc1 BcellGSE12603 98269482 98270042 560 0
hScc1 CdLSGSE12603 98269338 98270151 813 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1224 Unknown pSILAC miR-30 CHD1 down 75-50% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000153922 n_a n_a n_a "epithelium, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved